<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10323

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMLQEKAQTPPEQWQTFLHQCLSTRIDIDEFTTLSKLMLARIPIKENILLDLLLQSRADARIAWDPLLPLYVDGLCRVGLVKVSSALRGLLRHSSILDGSSNSNSNSNQKEGEGDVSAKSVGGDRSTLMTDIKVVQDVMMFISTASIPKTSSEAADIYNATIEWIVALVAWHQRSLDVSTQNGGLMGEPDAVSLFESLGILLAALSGTGKGLEVLSSDFDRRLKNKLGQALAAYLPLCVDVSLPLRHRLEELQKGFGLFPDQPGNNANANAKALDHSGIEGMNVRALQFEAGVMDGPVVNTRAGLYVYINSMVVGRPLVDDTILINYLTNRYQGHNEVLIEEIITAAFDVLSNGVYRNESSRTMFLFRSFLVNKLPVFFAAISAASMVPISMEMCISQALSRLNPNAFPSFSQMFSMQGSSVLSDARQEFLFACASHKLIQESSIEQLLGENPMQTLPGGGPYVKDDLISQISSNHERAEQLIGEIESMEGNAGAIVGAVVEVMHSLCHQKETVTLKNICNSLSRRPQTLDAILLFRTTKQVLQPLCSILDSWKWDEDQGENQPVYDEFGSILLLVLAFKYRYDLSPSDMGISSNDSFLLKLMDRGACTQKLNELSEKQNKDLGAWIGALFIAEGISEETMSTCSPQEFYMLVTTLFDQSLGACESGKLDFDTLKGGFEYLLEPFLLPSLVVALTWLGNHIWESETDPTIPLKTLHSLVKPNSISGEAQAIHQTVLNITARSLEEQLKNVRTRNQSRTDIKPILDALEPYLSFRRVGSSHRTELDTWTSHTAGGLVGSIRSTLQALILWSSNPEISAAPHAYTHRQILAGIRILGATRVLASIIDEVKHQSETTGSGHVALDIATTIICAPMTESFAVDQNNYHPIDPMKESPPRCPILTLRDALTLAHENVPKLSEKDPLRAEVVVRLWRRVNLLMAPPSQVSNIDVSNIIQNMHLGVEGHDRMDLEPSAADVTGNAVGEDDPDNINQMLDKAAAAAAAAGMDGGIGVAQDMELDAGGAGLDAIDDVLNAADMAVGNPEFLDLDMEGMF
Length1049
PositionTail
OrganismPenicillium arizonense
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.053
Instability index44.26
Isoelectric point4.86
Molecular weight114658.32
Publications
PubMed=27739446

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10323
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.24|      12|      35|     445|     458|       1
---------------------------------------------------------------------------
  445-  458 (17.66/20.88)	EQLLGEnpMQTLPG
  479-  490 (21.58/14.87)	EQLIGE..IESMEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.56|      13|      36|     984|     996|       2
---------------------------------------------------------------------------
  984-  996 (21.86/15.21)	DNINQMLDKAAAA
 1022- 1034 (21.70/15.04)	DAIDDVLNAADMA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     253.05|      68|     229|     491|     559|       6
---------------------------------------------------------------------------
  492-  559 (119.79/100.34)	AGAIVGAVVEVMHSLCHQKETVTLKNI.CNSLSR...RPQTLDAI...LLFRTTKQVLQPLCSILDSWK.WDEDQG
  740-  789 (41.05/27.53)	............RSLEEQ.....LKNVrTRNQSRtdiKP.ILDALepyLSFR...RVGSSHRTELDTWT.SH....
  791-  854 (92.22/70.04)	AGGLVGSIRSTLQALILWSSNPEISAA.PHAYTH...R.QILAGI...RILGATR....VLASIIDEVKhQSETTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.34|      13|      27|    1006|    1018|       7
---------------------------------------------------------------------------
 1006- 1018 (22.52/13.02)	IGVAQDMELDAGG
 1035- 1047 (23.82/14.20)	VGNPEFLDLDMEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.34|      20|      36|      24|      43|      10
---------------------------------------------------------------------------
   24-   43 (33.26/24.66)	RIDIDEFTTLSKLMLARIPI
   60-   79 (37.08/28.47)	RIAWDPLLPLYVDGLCRVGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.00|      30|     304|     586|     617|      12
---------------------------------------------------------------------------
  586-  617 (48.38/43.87)	PSD.MGISSNDSFLLKLmdRGACT...QKLNELSEK
  884-  917 (45.62/33.05)	PIDpMKESPPRCPILTL..RDALTlahENVPKLSEK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10323 with Med5 domain of Kingdom Fungi
Unable to open file!