<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10320

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGANTNIHLIDGFSNIYWRIYTEDSRGTNQPQEGPANGYTILKHLSRLKDLEARLRSLNCLASSPRRLGLWVFSHTPDFESLNPLYLSGEENNKIVVGSTTLKVGASGSVTALDLVKGLSDNQGQGTQSGQPRPSQGQAPPRRQDGLINSAGIYAAFISAVTGSISLQLVRRHGALPLGSRTLFTAVEKMGYESPHVDNESIFSSSCLTTLNVQLTVGGTITISAQTVPQTGIMRLSSRDDVADLLSMQPGIDLWLCPNGTIARLVTANIDASTVPSPGYPTPGDVSAKRMQWKLDVVQWLRNLGLQIDSVEEEPWVEIEVWEAFYARLAGEAWRQSDDGQSALPLKRMLWPARFCFRRASSSTTTFETQMPLLEDPLDFAERWSSQASSLKLDHRVQNIHFPQERQIKDQEMSPSPKADHPESIESLSRIAQYPDLQTTNLVYPTPPDGAAAIGMNNPNPSEAFAEDSDFGLPNATPRNPQRNASGSGLSPGNGIGVGTGRYDASDEEDLFGEMNDRDFGSKGITDADFSFFDDPDFEGMGDEDVEQPQEIIQASHGPPGLEDETMIDAKPSPDPPLEIPNHSETEAHVSPMQQEGPQPNEPPLEERGAHSPTDRTGQTISPPLSPIEVKKILFPEPETNDGGSSTDIHGQGHYHPVTFEKKLRDWDQKYGTAGKFWFSAGGPSDTSEQTSAIPTIGLPHRNRSGANTTAAAKERSRANSSLIQIKQGPRSASVSGSDSDDSSDESAEVMPEHAPTPSTLALIPSLKRKRAPSETETMSAASPEKQLITTEANPALKAENFTFLGNFLANFSDWTLTGYFSALQSQQNPVLLLREDQLQIAQLLVEQITQSSLKHPLDEQIGPVNLESQSLLQTLDHTEFPGEVAKLDFKRYTSLQDEFTANHPQQQPPQYPAPPKDVPRGFIARLPAPHVRVRRGKEYLEALPPAIDFWETFGLEPAHGPKNISAYCIHPQAASQAAAVFLRRFGLLYQSCSLGSHTRGDDSVGFETGLKSWQSEPSSYESMMLILKDMCEELGAELSQSPPTAENCVVYIINPFTHTAALADICSAFWHLFQQLLVDSERRQVRPVNELVLQIIPMEFVMSSETMVVPSQADYLNLALEVYGRCRPREADTSSLLCTPPMCLADPLPRAISFRLAPERASPLQDGRSLHIACSRSLDQRWISVAWSDVPGSIQRTVSYCLKYRQSSATRPISEVRNEIWATTKHIMEKIQARWKVQLVATEPMESDEVEAWTSFADQYNKSRPGSLELAILSVNAIPDLILEPPIPPIPMAVFNPLSSSTPVSTPNPSNSVASPEQSGNAATPSSGGPTTYNAPTPTDMSLETDSEAVLTDICDESWLAVLSHRLNSSAHLTDFRPALSSGYLLRRKSANDGDGVFALAVNLIYSPRPPPAHDNVLKDTLSMYRDMATLARVKGIRCVQGNTLPWHIATALRAQELLSYTF
Length1468
PositionKinase
OrganismPenicillium arizonense
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.431
Instability index57.28
Isoelectric point5.00
Molecular weight160934.22
Publications
PubMed=27739446

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10320
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     264.06|      80|     122|     410|     531|       1
---------------------------------------------------------------------------
  412-  496 (133.32/65.66)	IKDQEMS....PSPKADHPESIESLSRIAQY....PDLQTTNLVYPTP.PDGAAAIgmnnPNPSEAFAEDSDFGLPNATPRNPQRNASGSGlSP
  529-  617 (130.74/92.57)	ITDADFSffddPDFEGMGDEDVEQPQEIIQAshgpPGLEDETMIDAKPsPDPPLEI....PNHSETEAHVSPMQQEGPQPNEPPLEERGAH.SP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.74|      37|     122|     750|     799|       2
---------------------------------------------------------------------------
  699-  725 (40.91/17.22)	.........P.TIGL.P..HRNRSGANT...TAAAKER....SRANS
  756-  799 (50.04/41.83)	PE...HAPTPSTLALiPSlKRKRAPSETEtMSAASPEKqlitTEANP
 1321- 1347 (32.80/11.39)	PEqsgNAATPSSGG..PT..TYNAPTPTD.MS...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     260.13|      80|     881|       2|      87|       4
---------------------------------------------------------------------------
    2-   87 (129.56/86.25)	DFPGgantNIHLIDgFSNiYWRIYTE..DSRGTNQPQEGPANGYTILK.HLSRLKDLEARL.RSLNCLASSPRRLGLW.VFSHTPDFESLN
  884-  968 (130.56/71.30)	EFPG....EVAKLD.FKR.YTSLQDEftANHPQQQPPQYPAPPKDVPRgFIARLPAPHVRVrRGKEYLEALPPAIDFWeTFGLEPAHGPKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.21|      16|      24|     348|     365|       6
---------------------------------------------------------------------------
  348-  365 (27.93/24.72)	LPLkrMLWPARFCFRRAS
  375-  390 (29.28/18.37)	MPL..LEDPLDFAERWSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.35|      14|      15|    1152|    1165|       9
---------------------------------------------------------------------------
 1152- 1165 (24.90/14.13)	PLPRAISFRLAPER
 1168- 1181 (24.45/13.71)	PLQDGRSLHIACSR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10320 with Med13 domain of Kingdom Fungi
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