<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10319

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRTQPASFQARPPSPSSPAAGSLKENHRLPISSDHIPQTPTSPPLMSVSDQNDAANFTSSHTSPNQATVHPPNVSSPPSSTPMSTQASQQQPMSSTNSFPTPASSVNGYPLNATGEDKDGRKYFNVNTNDSTENSGPDQSSEHRRTDHNRQTFSTDTNTIGRGQQHSDPDAMEVDTEPARRSDISNLGLDSLQKELTSAFHLCKSSPIVTGPDPSVDLVSLYGLGPIAHSVARLDPVTGEKINRLRKSYEGKLKGLGLAGRNKPFKQEPGAPGSLRHMTLWPEEEWQNQKVFGKQIKISDMDTALQDLQSRAMQMEPGPVPNNDFWEDILGHEKPVKNPASNEHSKKAASTPSNRPSMHSNAASPQPQPQEVDRPRPSRGRKRHYDDNSFAGYGEGFVDDEEDPGFYSNGEGTGKKKRKKDHVAKVSTPMSSGAVLAFTVGSITVALSHASHQMLIGRSIQGIGGGGIMALTELLLADLIPRQERGKWFSIRPGTWAPETVVGPIIDGGSAQSSASWR
Length520
PositionHead
OrganismPenicillium arizonense
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.05
Grand average of hydropathy-0.829
Instability index53.62
Isoelectric point6.64
Molecular weight56195.39
Publications
PubMed=27739446

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
transmembrane transporter activity	GO:0022857	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP10319
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     534.71|     171|     215|     102|     285|       1
---------------------------------------------------------------------------
  102-  285 (255.43/160.85)	PTPASSvNGYPLNATGEDKDGRkyfNVNTNDSTEN..SGP.DQSSEHRRTDHNR.QTFSTDTNTIGRG.QQHSDPDAME......VDTEpARRSDISNlGLDSLQKELTSAfHLCK.SSPIVTGpdpSVdLVSLYGLGPIAHSVARLDPVTGEKINRLRKSYEGKLKGLGLAGRnKPfKQEPGAPGSLRHMTLWPE
  319-  501 (279.28/137.35)	PGPVPN.NDFWEDILGHEKPVK...NPASNEHSKKaaSTPsNRPSMHSNAASPQpQPQEVDRPRPSRGrKRHYDDNSFAgygegfVDDE.EDPGFYSN.GEGTGKKKRKKD.HVAKvSTPMSSG...AV.LAFTVGSITVALSHASHQMLIGRSIQGIGGGGIMALTELLLADL.IP.RQERGKWFSIRPGTWAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.71|      24|      24|      14|      37|       2
---------------------------------------------------------------------------
   11-   35 (37.45/13.92)	QA........rPPSPSSPAAG...SLKE.NHRLPISS
   36-   61 (32.52/11.21)	DH........iPQTPTSPPLM...SVSDqNDAANFTS
   62-   97 (30.74/10.24)	SHtspnqatvhPPNVSSPPSStpmSTQA.SQQQPMSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10319 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSDRTQPASFQARPPSPSSPAAGSLKENHRLPISSDHIPQTPTSPPLMSVSDQNDAANFTSSHTSPNQATVHPPNVSSPPSSTPMSTQASQQQPMSSTNSFPTPASSVNGYPLNATGEDKDGRKYFNVNTNDSTENSGPDQSSEHRRTDHNRQTFSTDTNTIGRGQQHSDPDAMEVDTEPARRSDISNLGLD
2) VFGKQIKISDMDTALQDLQSRAMQMEPGPVPNNDFWEDILGHEKPVKNPASNEHSKKAASTPSNRPSMHSNAASPQPQPQEVDRPRPSRGRKRHYDDNSFAGYGE
1
293
192
397










Molecular Recognition Features






MoRF SequenceStartStop




1) FWEDIL
327
332