<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10316

Description RNA polymerase II holoenzyme cyclin-like subunit
SequenceMSANYWTSSQYNNNLYTKPELNDIRLSLFTKELQKYGNYWLTIPLQFKDQESGSNKQISIYAKELHYDRDYNLRIYLYLQLMKLGKKFQLKQVIISSAMIYLQRFLLKCSIKECNVYYLITTCLYLASKVEECPIHIKSLNLIAKSYWPDFIHSDCTKITEFEFYLIEELESYMIVYHPYDSLKKILQSFTEYVKENLEKENLDNIEDYLLNYEYLQDTWAIINDSYVTDSHLLFHPHVIAITSLLLSIVLKGEQLDQKIEKTTKIIKDIENKKNVEKSNNKAPINNKTVSSDVGSTNNSVNNTTNMHSSETKEFIIPNEEYDEMLMNLGLSGDNNIQNKTLTKDPMSPNINSNSETTELEEGNFQYQGLKEELKQNLIEKELIHKKTAKLNEFVAFSLINMQDIEDCFKEIMILYQFWTGFSVVGQSTKFDKLQKNKYNEEWIRFLLYRVYQTKA
Length456
PositionKinase
OrganismHanseniaspora uvarum (Yeast) (Kloeckera apiculata)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycodaceae> Hanseniaspora.
Aromaticity0.12
Grand average of hydropathy-0.484
Instability index48.22
Isoelectric point5.56
Molecular weight53781.72
Publications
PubMed=27856586

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
cyclin-dependent protein serine/threonine kinase regulator activity	GO:0016538	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10316
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.48|      31|      33|      26|      58|       1
---------------------------------------------------------------------------
   27-   57 (56.07/34.39)	SLFTKELQKYGNYWLTIPLQFKDQESGSN...KQ
   59-   92 (49.41/29.15)	SIYAKELHYDRDYNLRIYLYLQLMKLGKKfqlKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.92|      11|      21|     107|     117|       2
---------------------------------------------------------------------------
  107-  117 (20.38/12.62)	LKCSIKECNVY
  126-  136 (19.53/11.82)	LASKVEECPIH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.07|      24|      25|     142|     165|       3
---------------------------------------------------------------------------
  142-  165 (46.31/23.17)	LIA..KSYWPDFIHSDCTK..ITEF.EFY
  166-  193 (31.92/14.24)	LIEelESYMIVYHPYDSLKkiLQSF.TEY
  378-  398 (27.85/11.72)	LIE..K....ELIHKKTAK..LNEFvAFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.31|      23|      50|     285|     307|       4
---------------------------------------------------------------------------
  285-  307 (40.90/24.06)	INNKTVSSDVGSTN.NSVNNTTNM
  337-  360 (37.41/21.48)	IQNKTLTKDPMSPNiNSNSETTEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10316 with CycC domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IQNKTLTKDPMSPNINSNSETTELEEGNFQ
2) VEKSNNKAPINNKTVSSDVGSTNNSVNNTTNMHSSETKE
337
276
366
314










Molecular Recognition Features






MoRF SequenceStartStop




1) WIRFLLYRVYQT
443
454