<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10315

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPYNENLVSWSKNGIILYAKGSAVALTFFESINGTNWRLHPEKYYNLGTYENNKLNNSHAFKDSEQKRSQNQSPVSNPPKTSKLNFNISRIEFSNWGSLSGDLVAVADEIGTLSILMVGVDAGGVSTLDHMAMLFQDSMIKNSSIKDTQNHSAIKNLELLDGPEKVQSNHFTNLYSTAILDLQWVCSTKQFMTSRLNAGWKNPNPGSGPAVSKLSFNSLPSFGVYHPQFIKYSCACIRRNGEFSLWYQFSNSKETKKQTLRVAENEWLDNAELAHCKENNVFYLTTYSNLDNLVSVYRISINWNSQQQQQQKQQDPQQQQQQSLEDPTLNCEKIFEMTPSRMHGDEIINLVKCSLLSRSYDANSDADLLLIYEIAGKRTSIVKRYSIQKTAPTALFTNILLKDSTHLVNTASFYQPKFVEDISIDDIVESVQYQYIQNVVHFRLASGKSKMFRKGSWKEFVYNEQIVSDQVSPLEAGFSFPVLPTNLEWCTLSPLACGLLYKIQGDPLLHYTPYLSDKLTITENKIISLAYNFVSCTHKSCMGEDATIAIQTYLMALNNTEKREQIIMAIVQTCFNFFGFLPNSAKEVVERIIITKPMQKLMLLQLELSGVFENSSRVYLMSRSIMCFRDILFAFNTVVRNAQMMIQHSATMSAQNNGGKLYQFSFSKQDLFFSLLPISKWFVKYVTFLMQQLLFVMNNSSDENNLFALSVISGKVTRVLLLAILQEINKIKKLVTKFPETAYPALNDSSIFLLKVFEDSPVSFEKFETFLVDINNKIKKNDDALLEAPANSTTAHELSSREAYILMKGTIPRKFSYFKDIVLSETFNKVIPEIDAANLFFTDTSNLKLFADEFYNKKYFQLLQPINEGLIVENEKIRMESSASFSNMDFDDVTKEPLYFNNNPADGNQNAAKDKYKRCVRCGNITMAGYVIPKSKTVVATSISTRRWCSVYSKTCTCSGMLHEI
Length965
PositionTail
OrganismHanseniaspora osmophila
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycodaceae> Hanseniaspora.
Aromaticity0.11
Grand average of hydropathy-0.238
Instability index39.89
Isoelectric point7.94
Molecular weight109765.20
Publications
PubMed=27856586

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10315
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     196.94|      62|     187|     613|     678|       2
---------------------------------------------------------------------------
  613-  678 (104.39/75.53)	ENSSR.VYLM.....SRSIMCFRDILFA..FNTVVRNaqmmIQHSATMSAQNNGGKLYQFSFSKQDLFFSLLPI
  797-  866 (92.55/57.69)	ELSSReAYILmkgtiPRKFSYFKDIVLSetFNKVIPE....IDAANLFFTDTSNLKLFADEFYNKKYFQLLQPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     240.20|      79|     127|       1|      87|       3
---------------------------------------------------------------------------
    1-   87 (115.07/95.61)	MPYNENLVswsKNGIILYAKGSAvALTFFESINGTNwRLHPEKYYNLgtYENNKLN.....NSHAFKDSEQKRS.QNQSPVSnPPKTSKLNFN
  133-  217 (125.14/75.01)	MLFQDSMI...KNSSIKDTQNHS.AIKNLELLDGPE.KVQSNHFTNL..YSTAILDlqwvcSTKQFMTSRLNAGwKNPNPGS.GPAVSKLSFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.13|      32|     188|     313|     353|       4
---------------------------------------------------------------------------
  313-  353 (51.01/51.67)	QQDPQQQQQQSLEDP.TLNCEKIFEMTpsrmhgdeiINLVKC
  504-  536 (53.12/33.40)	QGDPLLHYTPYLSDKlTITENKIISLA.........YNFVSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.76|      42|      46|     687|     732|       5
---------------------------------------------------------------------------
  687-  732 (62.01/53.11)	TFLMQQLLFVMNNSSdennLFALSVI.SGKVTRVLLLAILQEI.NKIK
  736-  779 (62.74/43.03)	TKFPETAYPALNDSS....IFLLKVFeDSPVSFEKFETFLVDInNKIK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10315 with Med16 domain of Kingdom Fungi
Unable to open file!