<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10313

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDTASIFDQFRNLIINSVENQCSPNQYFIFYNEFFNEKFGIALKKTEPTLSASTGDTNLITDIKNESFPEDAIDSIKAATPPPIDDEQKKKIYEILSSCFIQTLRELSTRSEHFVTVTNYLVQVCFTDYNSSFVNNITEKIYDLGKENEAIVIYFFTKATNYFKSLSDQLIIDDFLVNDVPAFLLPNLVGNYGEMKSRQLFVSLAKLLISMLSKCELKEGNKFQFKDQSLYEKVMNFCESLSETSLMLSKNLYNLIESKFEIAEWKKTHMHADKSPFAIPVETPSITSPLPSALPGTLTSSKQGSILQQSSSNKHFYDVKLIRYYKNMWLNNKIQHCTTDEIDFFPKYQGIEMALNSNNPILPFESAIVDFIDTSFTCFAQFLNNKKYHQALNSNFTLLEKKWYLFIVKRVPLLVEKYCGVNRSYLAVKAVQDLDDKIIKVFRNYYATGRSNSADNDSTDLFDNFDSPSQPELDIRHDFLKSLCMMKLQNPSVLNKVFSNGDEMIDTNTITDHDLVLVKNKQNNFETIHNLKEYLENSFDSFDFESLCFHDTCISDKSESFDIIYMFQNFESISPNSQLIIAETLVNIMETAVEKFDYKLVAKVCALLSFNLGNSLPGIFALVNPNRLVIPLIKFLDDAWDEHKEQVFSTGTENENDSDVESFNDYIYFGFALVFLIYLQEQYKVDVIQTLVKITDVKKLETSFLLQYMQTYKISSKELKLPSTKEPYKVAKLLQDWTNSLFVENSISDELIKNADIKDLAVLVPFMFDQVISIFQSLVTTSIQQQPQNKNEFNAALANFNTIVVNSVEYFSQPFMMIGLVKIVFTLESTIKTLQSICISQDESLLDTFLNILTPLFNESGILSSESKVLQFILYRVTGPRLLLTMKNLKNLKAKEITENSATVNAKLDYLISRLGRICEAANMYDLNPSILEIDPNEPSPFENQDLSPKSSGSSTHTPVYFDFEITSDAPMNKIMNKQCNSFWNLHSSTFYNYDYLQKIIQIVGPDKFFSDIYRSLVFKVETNGIPTAGNTLKKGEKPGDDVDVAMPYLIYFSILLDFNDNNERLQILQFLESPLSSSFVESLESESTDAATTNKTKTEPDTAKASEETANDNDFDMLFGEDSTDNIDDVLMSDSSTKNEGTNLTNCGAAEKIAKFSFLKKNTFAYLFYQYYRNKAYPFESFAKFYQKYLDLLKRSII
Length1199
PositionTail
OrganismHanseniaspora osmophila
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycodaceae> Hanseniaspora.
Aromaticity0.12
Grand average of hydropathy-0.231
Instability index39.36
Isoelectric point4.84
Molecular weight137269.26
Publications
PubMed=27856586

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10313
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.85|      27|      34|     521|     554|       1
---------------------------------------------------------------------------
  521-  546 (33.39/19.58)	..........KQNNF.ETIHNLkeYLENSFDSFDFES
  547-  577 (35.68/25.86)	LCFhdtcisdKSESF.DII.....YMFQNFESISPNS
  579-  599 (22.78/ 8.34)	LII............aETLVNI...METAVEKFDYK.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.74|      29|      35|     869|     900|       2
---------------------------------------------------------------------------
  869-  900 (34.77/37.68)	V...LQFILYRVtGpRlLLTMKNLKNLKAK..EITEN
  904-  937 (41.97/27.67)	VnakLDYLISRL.G.R.ICEAANMYDLNPSilEIDPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.69|      35|     448|       2|      65|       3
---------------------------------------------------------------------------
    2-   49 (50.25/46.35)	DTASIFDQFRnliinsvenqcSPNQYFI.FYNEFFneKFGIALKKTEPT
  457-  492 (60.43/20.63)	DSTDLFDNFD...........SPSQPELdIRHDFL..KSLCMMKLQNPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.59|      59|     448|     607|     670|       4
---------------------------------------------------------------------------
  607-  670 (98.02/70.14)	LLSFNLGNSLPGIFALVNPnrlviPL.IKFLDDAWDEHKEQVFSTGTENENDS.....DVESFNDY.IYFG
 1056- 1121 (81.58/48.79)	LLDFNDNNERLQILQFLES.....PLsSSFVESLESESTDAATTNKTKTEPDTakaseETANDNDFdMLFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.56|      19|      34|     354|     372|       6
---------------------------------------------------------------------------
  331-  345 (20.83/11.01)	....NNKIQHCTTDEIDFF
  354-  372 (34.05/23.60)	ALNSNNPILPFESAIVDFI
  391-  407 (29.68/19.44)	ALNSNFTLL..EKKWYLFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.55|      20|      27|     768|     787|       7
---------------------------------------------------------------------------
  768-  787 (33.50/22.92)	FDQVISIFQSLVTTSIQ..QQP
  793-  814 (25.69/15.71)	FNAALANFNTIVVNSVEyfSQP
  827-  842 (19.36/ 9.87)	LESTIKTLQSI...CIS..QD.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.81|      11|      27|     675|     685|       8
---------------------------------------------------------------------------
  675-  685 (19.51/13.83)	FLIYLQEQYKV
  704-  714 (20.30/14.77)	FLLQYMQTYKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.17|      12|      27|     161|     172|       9
---------------------------------------------------------------------------
  161-  172 (21.02/11.69)	NYFKSLSDQLII
  191-  202 (22.15/12.70)	NYGEMKSRQLFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.26|      15|     426|     294|     308|      11
---------------------------------------------------------------------------
  294-  308 (26.16/16.75)	LPGTLTSSKQGSILQ
  721-  735 (25.09/15.75)	LPSTKEPYKVAKLLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      57.42|      13|      35|     211|     223|      12
---------------------------------------------------------------------------
  211-  223 (23.84/15.12)	MLSKC..ELKEGNKF
  234-  246 (18.67/10.08)	VMNFC..ESLSETSL
  247-  260 (14.91/ 6.41)	MLSKNlyNLIE.SKF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10313 with Med5 domain of Kingdom Fungi
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