<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10309

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMNEGDWRNSFSEQERAKYRTSLAQLLVQISKTNNGKSADIEKLKKTAADFEQNLYDSSSSAANYIEAIKKRIELTANAKQNAQKQQLQQQAIAAKNGGTTAGMQDPRSPTNGNTNNNSNNGSSSSTKNYAMNMVMNQKALMNQNLQLQQQQQQYQQQQPGTANTAPNAGSNGRQQSSRYHQLTPEQQQLLHEIKYTPIPRELLSRIPNLPPNVNTWQQIMELQLGDNEITKKIYRYHQQMLLRDRQQNQALGNANNANLTNKTDNNSDLASSSASQPQQQQQQLQQFQLLQQQKQQRLQLLQQQKMQQQQQQQNKSSNNTTNGTTFNNNKSNANGSGSSVNSSASQAARFISPEQQKALLENAQLLIKKLQKTGRLPPKLTTEEYQTFVKRYLNEVASKRINQIRQQQAQQQALNKTEAGINTNMNLPNSNVTAIQAAALAQQRRLQQQQQQQQQQQQQEFAKTNSDTRIAGGCNTLPGSAAVSNGTTPQPNPTMLPMNNLTSQQQQQLQAQYLLQQQKAQQQNMTKQQQQQQAVAAASAAHRTAQPSSHTPGQASHASTQSVTSKSSAPGVNILSKIDELFNPQEQKMLYENAKNAIKAGQQQGKLAAVLSTQQQNFYIRKYVQQMCIKKLAAMKQASAAAAAQKLQQIPHQPQLPQSQLQQQEVVPQTSIPQQTDSTPQDLNMQGRKLSQQKSSSQQAKASVPANSVSKTKGSATAKGASPSVGRTPVPATSPLQGASTSNTKAPSSSYINPFKEDEQALRELLIKKREITARHKKRQEVYCHSEADIFLGTLSDCLGLFDEPHEAIAPIQPYIVDFINNTGKKKLTKTLLKARDQEMLISSIKDDNKLIMESKNNKVMYTKSIFDPDGGLKLQSKEIGSLFNFLDCENPVIRSLSNDREAGMKTAMEKMAEETPNNKKRVNETNEDASTKKMKSGSTSTSPEDILSSASSTESAISASTTIDVKPSSISGYEKSNLETDIWDYNYWQDLTHD
Length995
PositionTail
OrganismHanseniaspora osmophila
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycodaceae> Hanseniaspora.
Aromaticity0.04
Grand average of hydropathy-0.961
Instability index57.47
Isoelectric point9.58
Molecular weight110492.71
Publications
PubMed=27856586

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10309
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     758.73|     143|     143|     294|     436|       1
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   31-   99 (61.54/17.42)	..........................................................................KTN.NGK....SA.....D..I..EKLK......KTAADF.....EQN..LYDsssSAANYIEA..IKK..RI...ELTANAKQ...................N....AQKQQLQQQAI.AAKNGGT
  113-  259 (160.13/57.67)	NTNNNSNNGsssstknyamNMVMNQ..........KALMNQNLQlQQQQQQYQQQQP..GTANTAPN..........A.......GS.....N.......GR......QQSSRYhqLTPEQQQLLHE...IKYTPIPRelLSRIPNLP.PNVNT..WQQIMELQLgdNEITKKiyRYHQqmlLRDRQ.QNQALgNANNANL
  294-  421 (209.72/77.92)	...................................KQQRLQLLQ.QQKMQQQQQQQN..KSSNNTTNGTTFNNNKSNANGS....GS.....S..V..NSSA......SQAARF..ISPEQQKALLE...NAQLLIKK..LQKTGRLP.PKLTTEEYQTFVKRYL..NEVASK..RINQ...IRQQQAQQQAL.NKTEAGI
  422-  517 (127.59/44.38)	NTNMNLPNS..........NVTAIQ.....aaalaQQRRLQ..Q.QQQQQQQQQQQEfaKTNSDTRIAGGCNT....LPGS....AA.....V..S..NGT................TPQPNPTML.....................PmNNLT..................SQ..........QQQQLQAQYL.LQQ....
  518-  650 (143.92/51.05)	........................Q..........KAQ.....Q.QNMTKQQQQQQA..VAAASAAHRTA..QPSSHTPGQ....AShastqS..VtsKSSApgvnilSKIDEL..FNPQEQKMLYE...NAKNAIKA..GQQQGKLA.AVLSTQQQNFYIRKYV..QQMCIK..KLAA...MKQASAAAAA..QKLQ.QI
  651-  737 (55.82/15.08)	PHQPQLPQS..........Q...LQqqevvpqtsiPQQTDSTPQ.DLNMQGRKLSQQ..KSSSQQAKASVPANSVSKTKGSatakGA.....SpsV..GRTP......VPAT.....SPLQ................................................................................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10309 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAAAQKLQQIPHQPQLPQSQLQQQEVVPQTSIPQQTDSTPQDLNMQGRKLSQQKSSSQQAKASVPANSVSKTKGSATAKGASPSVGRTPVPATSPLQGASTSNTKAPSSSYINPF
2) IYRYHQQMLLRDRQQNQALGNANNANLTNKTDNNSDLASSSASQPQQQQQQLQQFQ
3) KKRIELTANAKQNAQKQQLQQQAIAAKNGGTTAGMQDPRSPTNGNTNNNSNNGSSSSTKNYAMNMVMNQKALMNQNLQLQQQQQQYQQQQPGTANTAPNAGSNGRQQSSRYHQLTPEQQQLLHEIKYTPIPRELLSRIPNLPPNVNTWQQIME
4) KRINQIRQQQAQQQALNKTEAGINTNMNLPNSNVTAIQAAALA
5) LQLLQQQKMQQQQQQQNKSSNNTTNGTTFNNNKSNANGSGSSVNSSASQAARFISPE
6) LSNDREAGMKTAMEKMAEETPNNKKRVNETNEDASTKKMKSGSTSTSPEDILSSASST
7) QRRLQQQQQQQQQQQQQEFAKTNSDTRIAGGCNTLPGSAAVSNGTTPQPNPTMLPMNNLTSQQQQQLQAQYLLQQQKAQQQNMTKQQQQQQAVAAASAAHRTAQPSSHTPGQASHASTQSVTSKSSAP
640
233
69
399
298
897
443
755
288
221
441
354
954
570










Molecular Recognition Features






MoRF SequenceStartStop




1) WDYNYW
984
989