<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10296

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMNTQLDELQWKSPEWIQAFGLRTDNVLDYFAESPFFDKTSNNQVIRMQQQFDVQQQQQQQQQQQQQQQQHQMMMANGLANESNAVPFNEYPSNRQYILQNYPVHYSLEKELRKLAKGIEYVLCYVREPDLWIIRKQEKLDTAQWKTLSDYYIIGANVYMSPQLGKIVGSRMLSTNYHLSKALSKLAQLTNGFTPSQGFRFVDVAGSPSSGNAPAATSTTTTALSGSSGIPSSAPATTHLGAIATPAIGKTPSTASLNTGGGLNTLDTGINTNVGSTPALGSKEVLSAEVADKLLLTSIKSEPTYL
Length305
PositionHead
OrganismHanseniaspora osmophila
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycodaceae> Hanseniaspora.
Aromaticity0.08
Grand average of hydropathy-0.447
Instability index45.49
Isoelectric point6.43
Molecular weight33578.28
Publications
PubMed=27856586

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10296
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      86.71|      19|      20|     204|     222|       1
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  204-  217 (19.27/ 7.75)	...........AGS.PSSGNAPAATS
  218-  238 (23.61/10.90)	TTTTA..lsgsSGI.PSS..APATTH
  239-  255 (20.47/ 8.63)	LGAIA.........tPAIGKTPSTAS
  257-  281 (23.36/10.73)	NTGGGlntldtGIN.TNVGSTPALGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.46|      15|      17|     152|     166|       2
---------------------------------------------------------------------------
  152-  166 (25.93/19.70)	IIGANVYMSPQLGKI
  171-  185 (24.53/18.25)	MLSTNYHLSKALSKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.31|      12|      17|     100|     111|       3
---------------------------------------------------------------------------
  100-  111 (21.87/16.03)	NYPVHYSLEKEL
  119-  130 (22.44/16.61)	EYVLCYVREPDL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10296 with Med6 domain of Kingdom Fungi
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