<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10294

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMNPPTKYQLEPPTGVYPVSKHSKVYPDFEPWKHKPIEDKLLLNFVAKGYYEPAKVSFETISAKSSVIQEPLSNLANRLSSNFTEIFKLREERVNKISNSANEDGSSFTENLTPNAANSMNFFHNLSGKDFKLPRRVTLTDAKREQWLQDLTDSDVKMNQLVKSIPHGFKRKQLLEQLYLKQVPFSRAIWLIKYCYCVEWSVLSSRTKEKHEYNSLVAKIYQEWTSSMVQLLERLVFDMSLGADHSIPTNTKRSFSQNSIGRKYVKPNMKSPEFDNAAFSNSKPAAQSPNFSLSEKMSPKFDEHGNDNLSKSKKSDSNMKNFSTSNGSTYNKVKSVQHEEKDLLTWKSNIKYFLKLVGNCYGLGLMDKYLFVNWLVEFFSKMENFEYYPITLHILTSFWSDIVDNENSDSFILGKITESLLHSYYMVSHSKSMLNDSNFLINDVKKNEKIRAVFLDTLKKLISQIFHHQSLEIFVMTDNSKWNLYKPCLEDILDLSQRAVSDEIRKKFELITYRNDTLKKKFQSNSPGQENECCLKLSSCENIIMLRANFHLLNLLDNNKPTDDWDAFLNDMTTDDLIQMFLWTVSPTRASHYESVHLVARLLIMKLSIEGKEQLEIESEFWKMIFLMAKANNLTDFVDFDQLQALANVLIVYGIVKVPTYIRKLISSGVLYSPSQKAKKFHCDLLISLKIQPVMKYQFNMVLKKVDDKALTSGFHFDQLVFLAEQCKQIFITKSENKSLLKKAPGCVKIMVADWYLNSLVTSFGKDEETPFIDRSTIKRVYMHLCEDLQQFHHFYRWIESIVYHQQLSDIGAMEQMIDILLAFQKLFPLLINDPLSFMKSTIHLYLNKLKSVDTRSFQIIQFNPFWKFFLISFDNLLQMDASLHHQLSELCEIENERLREFSKSNHQLALSSSQQLGKKIRDLIAAPSEKSLTDDRLYLLSIQIVSRQEYAKYLPFILKRKHMEAESTHVFLSDLVLLLSLKLISLDFITKMFGNTTIMQMLTYETNDPYFIFQKKHYIKQNYESIVAHCLKVNDLDYLAYLIFTYGSSSTRVRVTNNTLKKLLPRHCEFIFALLHTHKNGDSDDQEAYMSLFEKLNFSNLYIFQAFVQCLLTDETFLLKELGTMSMKVSLVIESCQYSYLVAHLFDTITSPTLLNAVLEIVLINFLNECFIRGDDXTYVHCNKSLITTLTKLLKTQENLKIHERVFQSFETLLSECFKLHLSEACKEEKVFSILIELLIIFERPLFDYIVAFEKTSLITLLYXFFQDKPELCLKNKLFIYEILHHLKSQYTYLTTLDPTKLNQIPQELVALPPFHLSSFDSVKTAPASSAMGLSYIDHRDAMKYINSKYKNLNEFHLYNRKYKNHEEMVEIPEFLHLANYAEDKHSKKLNDTFVNLSLFDAKLERKDIS
Length1410
PositionKinase
OrganismHanseniaspora osmophila
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycodaceae> Hanseniaspora.
Aromaticity0.12
Grand average of hydropathy-0.247
Instability index37.49
Isoelectric point7.86
Molecular weight164139.52
Publications
PubMed=27856586

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10294
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     407.51|     135|     151|     382|     532|       1
---------------------------------------------------------------------------
  204-  270 (37.08/11.56)	..................................................SRTKEKHeYNS..LVA......KIYQEWTSSMVQL.LERLVFDMSLGAdHSIPTNTKRSFSqnsigrkyvKPNMKS............................................
  382-  529 (200.03/142.63)	ENFEYYPITLHILtsfwsDIVDN....ENSDSFILGKITESLLHSY.YMVSHSKSML.NDSNFLINDVkkneKIRAVFLDTLKKL.ISQIFHHQSLEI.FVMTDNSKWNLY.........KPCLEDILDLSQrAVSDEIRkkfELITYRNDTLKKKFQSN.....SPGQE
  540-  641 (134.09/70.29)	ENIIMLRANFHLL.....NLLDNnkptDDWDAFLNDMTTDDLIQMFlWTVSPTRASH.YESVHLVARL....LIMKLSIEGKEQLeIESEFWKM...I.FLM...AKAN.............NLTDFVDFDQ......................................
  865-  915 (36.30/ 8.72)	..........................................................................................FWK....F.FLI....................SFDNLLQMDA.SLHHQLS...ELCEIENERLREFSKSNhqlalSSSQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.85|      16|     206|    1070|    1090|       3
---------------------------------------------------------------------------
 1070- 1090 (24.40/24.38)	FIFALLHTHKNgdsddQEAYM
 1279- 1294 (30.45/16.62)	FIYEILHHLKS.....QYTYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.56|      40|      63|    1307|    1346|       4
---------------------------------------------------------------------------
 1307- 1346 (69.55/46.79)	QELVALPPF.HLSSF..DSVKTAPASSAMGLSYIDHRDAMKYI
 1367- 1409 (59.01/38.48)	EEMVEIPEFlHLANYaeDKHSKKLNDTFVNLSLFDAKLERKDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.36|      22|      24|     129|     150|       6
---------------------------------------------------------------------------
  129-  150 (37.46/24.29)	DFKLPRRVTLTDA..KREQWLQDL
  154-  177 (29.90/17.85)	DVKMNQLVKSIPHgfKRKQLLEQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.92|      39|     384|     340|     380|      12
---------------------------------------------------------------------------
  340-  380 (67.88/50.67)	KDLLTWKSNIKYFLKLVGNCYGLGLMDKYLfvNWLVEFFSK
  727-  765 (69.03/44.92)	KQIFITKSENKSLLKKAPGCVKIMVADWYL..NSLVTSFGK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10294 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) EFQTIRDYIKFLDL
223
236