<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10294

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMNPPTKYQLEPPTGVYPVSKHSKVYPDFEPWKHKPIEDKLLLNFVAKGYYEPAKVSFETISAKSSVIQEPLSNLANRLSSNFTEIFKLREERVNKISNSANEDGSSFTENLTPNAANSMNFFHNLSGKDFKLPRRVTLTDAKREQWLQDLTDSDVKMNQLVKSIPHGFKRKQLLEQLYLKQVPFSRAIWLIKYCYCVEWSVLSSRTKEKHEYNSLVAKIYQEWTSSMVQLLERLVFDMSLGADHSIPTNTKRSFSQNSIGRKYVKPNMKSPEFDNAAFSNSKPAAQSPNFSLSEKMSPKFDEHGNDNLSKSKKSDSNMKNFSTSNGSTYNKVKSVQHEEKDLLTWKSNIKYFLKLVGNCYGLGLMDKYLFVNWLVEFFSKMENFEYYPITLHILTSFWSDIVDNENSDSFILGKITESLLHSYYMVSHSKSMLNDSNFLINDVKKNEKIRAVFLDTLKKLISQIFHHQSLEIFVMTDNSKWNLYKPCLEDILDLSQRAVSDEIRKKFELITYRNDTLKKKFQSNSPGQENECCLKLSSCENIIMLRANFHLLNLLDNNKPTDDWDAFLNDMTTDDLIQMFLWTVSPTRASHYESVHLVARLLIMKLSIEGKEQLEIESEFWKMIFLMAKANNLTDFVDFDQLQALANVLIVYGIVKVPTYIRKLISSGVLYSPSQKAKKFHCDLLISLKIQPVMKYQFNMVLKKVDDKALTSGFHFDQLVFLAEQCKQIFITKSENKSLLKKAPGCVKIMVADWYLNSLVTSFGKDEETPFIDRSTIKRVYMHLCEDLQQFHHFYRWIESIVYHQQLSDIGAMEQMIDILLAFQKLFPLLINDPLSFMKSTIHLYLNKLKSVDTRSFQIIQFNPFWKFFLISFDNLLQMDASLHHQLSELCEIENERLREFSKSNHQLALSSSQQLGKKIRDLIAAPSEKSLTDDRLYLLSIQIVSRQEYAKYLPFILKRKHMEAESTHVFLSDLVLLLSLKLISLDFITKMFGNTTIMQMLTYETNDPYFIFQKKHYIKQNYESIVAHCLKVNDLDYLAYLIFTYGSSSTRVRVTNNTLKKLLPRHCEFIFALLHTHKNGDSDDQEAYMSLFEKLNFSNLYIFQAFVQCLLTDETFLLKELGTMSMKVSLVIESCQYSYLVAHLFDTITSPTLLNAVLEIVLINFLNECFIRGDDXTYVHCNKSLITTLTKLLKTQENLKIHERVFQSFETLLSECFKLHLSEACKEEKVFSILIELLIIFERPLFDYIVAFEKTSLITLLYXFFQDKPELCLKNKLFIYEILHHLKSQYTYLTTLDPTKLNQIPQELVALPPFHLSSFDSVKTAPASSAMGLSYIDHRDAMKYINSKYKNLNEFHLYNRKYKNHEEMVEIPEFLHLANYAEDKHSKKLNDTFVNLSLFDAKLERKDIS
Length1410
PositionKinase
OrganismHanseniaspora osmophila
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycodaceae> Hanseniaspora.
Aromaticity0.12
Grand average of hydropathy-0.247
Instability index37.49
Isoelectric point7.86
Molecular weight164139.52
Publications
PubMed=27856586

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10294
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     407.51|     135|     151|     382|     532|       1
---------------------------------------------------------------------------
  204-  270 (37.08/11.56)	..................................................SRTKEKHeYNS..LVA......KIYQEWTSSMVQL.LERLVFDMSLGAdHSIPTNTKRSFSqnsigrkyvKPNMKS............................................
  382-  529 (200.03/142.63)	ENFEYYPITLHILtsfwsDIVDN....ENSDSFILGKITESLLHSY.YMVSHSKSML.NDSNFLINDVkkneKIRAVFLDTLKKL.ISQIFHHQSLEI.FVMTDNSKWNLY.........KPCLEDILDLSQrAVSDEIRkkfELITYRNDTLKKKFQSN.....SPGQE
  540-  641 (134.09/70.29)	ENIIMLRANFHLL.....NLLDNnkptDDWDAFLNDMTTDDLIQMFlWTVSPTRASH.YESVHLVARL....LIMKLSIEGKEQLeIESEFWKM...I.FLM...AKAN.............NLTDFVDFDQ......................................
  865-  915 (36.30/ 8.72)	..........................................................................................FWK....F.FLI....................SFDNLLQMDA.SLHHQLS...ELCEIENERLREFSKSNhqlalSSSQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.85|      16|     206|    1070|    1090|       3
---------------------------------------------------------------------------
 1070- 1090 (24.40/24.38)	FIFALLHTHKNgdsddQEAYM
 1279- 1294 (30.45/16.62)	FIYEILHHLKS.....QYTYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.56|      40|      63|    1307|    1346|       4
---------------------------------------------------------------------------
 1307- 1346 (69.55/46.79)	QELVALPPF.HLSSF..DSVKTAPASSAMGLSYIDHRDAMKYI
 1367- 1409 (59.01/38.48)	EEMVEIPEFlHLANYaeDKHSKKLNDTFVNLSLFDAKLERKDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.36|      22|      24|     129|     150|       6
---------------------------------------------------------------------------
  129-  150 (37.46/24.29)	DFKLPRRVTLTDA..KREQWLQDL
  154-  177 (29.90/17.85)	DVKMNQLVKSIPHgfKRKQLLEQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.92|      39|     384|     340|     380|      12
---------------------------------------------------------------------------
  340-  380 (67.88/50.67)	KDLLTWKSNIKYFLKLVGNCYGLGLMDKYLfvNWLVEFFSK
  727-  765 (69.03/44.92)	KQIFITKSENKSLLKKAPGCVKIMVADWYL..NSLVTSFGK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10294 with Med12 domain of Kingdom Fungi
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