<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10290

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSLADQPGELYDQPTLKASQFNGKKTDSLLPRDLSRLSDSNNAIDFDEIDLHKLLTSHLLVKNVEKINYHQYLSSTMPDSDDQWCFQAELFLRQESPHCLVSLFSKELWCFSINDDPVPVPYPVENXCSNASETDNDDLXFSKLTGXVENDSPKVRKSPTDMLTLSSNNSENPPFDSKLLNREYSGLKPRKPDKVGQFTAQFSKPNLPTAYAIFLKAVRRAIYLNLSLSSNNQYVPFGNSCIFTDENKIINFDPHLFENGELTLSLSIRSLDMLMLSEYFDGAPKRLHAVLYMAPSSVKASLYFPDSLEKNISSEPPINAESVLKTLLASHGINLFHKKNDIKWIKIVPSLIHLSGQTPPISSYIHATAQDQLAQNTLKKYILWPLDLLFVQPALQYNEPPSTNSQVPEXFSFDEAFDLISDFAQLKLTSSYKIQGATSNKSSTGPLSSGASYYSDPYVSIGSVLPHKHSVSPNNHHTTSATTTPLHKSSPLLNYVTKNSPDDSLNNHTMLPEQNIIYEEXNGRTSDLGKNEHLLSPMETAHLDSNEALLQIDPMELPQISQKQEIGVPPLESQQAQQNENDFGISVSSFDAENNNTDSDMKDLFGDDDDEDVDXDDNEELNRANTETSXHVAENMPPQVGSPDIPLLNIHEQHDSSSNLTKTAEQASKSVPSSTLPLKRYLDIPFDEITQTDLYNDPGAPLPVETPREKRQSVYAPLNFNPIIEANVDNKYKNGGKFFVSSLNQHQXASSKDGKASNDLDTFQHPSAAHLSSMALASNELXPTDKDEKSFKTCENAVESDGGELMDLDFDYASSGSEMSSDEDENGVITIQQLTNTXHTQPVTSLSALAALSTSSAKITNTKNQSHDFTAKHPVMLYKVPAEQPAPTSTEALFEDQDRAYRSSSAFSTESQYIPLTIPSSNLLAEPHHAVSMDFNNDLKNKMNSKLMSSAKSDLEVQPFNSNNGNLMTQNPLLSETVKSPATMDAMFWKQDLGTSFGGNARSDELLAQRSALFSPEFINFEKLNKSSPAKDYAQTTTDVGFPSNKKNDHHTQVLXFEDQKPLELDNKNMDAAVPSTNLLTMNSPELHTVNVLPFVLRHMPLFSIPQYYLAENPTISNTRCMQDFLNSFTSEIVFNPQLKEFGISERSFEVFTKLSSKSKIYTTLQSLFKNCTRMESTKLIDDFXKLEEPNVYVKKEDEEGNEVALKINSSSFDFIDALRFKPFKKEKSFSGLLLTSGNSEDCLDFMNNLVLQYNDFHLGHCDLVQLTPDDEPGLIHLKNFDSHTLLLLAAQIVTYCFTQQRHFKDQNKPLVIFLPFDETKHIHSIVEMCYKFAIVKNEVLNRLPNCELFLRLIPIKKLVTNPLTTIKECNKLCLSIYNILPRVTSKYTQLAHNPPEKVEIKLXLSKNAASNSLNNFHYDTYIHVAYSRSIDKEWISASWSTLDGSEFYVKTWYVGNSKTKFESFCNEIWATSLKFIALSNANNSSARANSSASSTLAASGFLKTCIVLARLDSILPDDELMHWRRLSSKTKQIHLAVVCCGLNTKFTMYDTTACAPNRKIFNVKPNSFDYNNLKEQKKLSDDNFVLCKPRNDTYMAVFKYALPLSNSQHRCSIKSGALLKFKSGFRFSAESAHDEXYVTKTNTDNSQKRFDEENLENTXFDFDFDDEKVAGDNENEGLVDKFEVNLLNCPHADSKRLLKTILKQYHDMSFLNPWFTVTEDDQDQLLPYHILAVSKILRNVVHLNVNIDKNGYDV
Length1755
PositionKinase
OrganismHanseniaspora osmophila
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycodaceae> Hanseniaspora.
Aromaticity0.09
Grand average of hydropathy-0.501
Instability index42.52
Isoelectric point5.22
Molecular weight195699.00
Publications
PubMed=27856586

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP10290
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.64|      30|      50|    1146|    1177|       1
---------------------------------------------------------------------------
 1146- 1177 (46.71/32.72)	ERSFEVFTKLSSKSkiYTTLQSL.FKNCTRMES
 1199- 1229 (45.92/26.25)	EEGNEVALKINSSS..FDFIDALrFKPFKKEKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.75|      39|      44|    1234|    1277|       2
---------------------------------------------------------------------------
 1239- 1277 (72.52/47.99)	NSEDCLDFMNNLV....LQYNDFHLGHCDLVQLTPDDEPGLIH
 1282- 1324 (62.23/31.02)	DSHTLLLLAAQIVtycfTQQRHFKDQNKPLVIFLPFDETKHIH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.99|      24|      44|     979|    1004|       3
---------------------------------------------------------------------------
  979- 1004 (40.36/31.17)	KSPATMDAMFWKQDLGtsFGGNARSD
 1026- 1049 (42.62/26.43)	KSSPAKDYAQTTTDVG..FPSNKKND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.31|      15|      22|      72|      86|       4
---------------------------------------------------------------------------
   72-   86 (31.73/19.06)	YLSSTMPD......SDDQWCF
   91-  111 (24.58/13.01)	FLRQESPHclvslfSKELWCF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.74|      28|      41|     644|     671|       5
---------------------------------------------------------------------------
  644-  671 (46.50/29.57)	DIPLLNIHE...QHDSSSNL.TKTAEQASKSV
  683-  714 (39.24/23.65)	DIPFDEITQtdlYNDPGAPLpVETPREKRQSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.93|      44|     797|     159|     209|       6
---------------------------------------------------------------------------
  159-  203 (73.84/52.81)	PTDMLTLSSNNSENPPFDSKLLNREYS..GLKPRKPDKvGQFTAQFS
  222-  267 (73.09/36.21)	IYLNLSLSSNNQYVPFGNSCIFTDENKiiNFDPHLFEN.GELTLSLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     295.48|      82|     160|     890|     978|       7
---------------------------------------------------------------------------
  504-  573 (51.17/17.43)	...................SLNNHTM...LPEQNIiyeexngrtsdlgknehLL..SPM.ETAH.LDSNEALlqIDPMELPQISQ.KQEIGVPPLES.................
  890-  978 (131.53/68.20)	TEAL.FEDQdrayrssSAFSTESQYIPLTIPSSNL.................LA..EPH.HAVS.MDFNNDL..KNKMNSKLMSSAKSDLEVQPFNSNNGNLMT.QNPLLSETV
 1052- 1134 (112.78/49.15)	TQVLxFEDQ.......KPLELDNKNMDAAVPSTNL.................LTmnSPElHTVNvLPFV..L..RH.M..PLFSIPQYYLAENPTISNTRCMQDfLNSFTSEIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.92|      37|      42|     310|     351|       8
---------------------------------------------------------------------------
  310-  351 (54.79/41.23)	KNISSEPPINA..ESVLKTLLASHGInlfhkKNDIKW....IKIVPSL
  353-  395 (51.13/28.11)	HLSGQTPPISSyiHATAQDQLAQNTL.....KKYILWpldlLFVQPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.36|      27|      46|     749|     780|       9
---------------------------------------------------------------------------
  749-  780 (37.48/28.95)	ASSKDGKASNDLDtFQHPSaahlSSMALASNE
  797-  823 (47.88/23.67)	AVESDGGELMDLD.FDYAS....SGSEMSSDE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10290 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ITQTDLYNDPGAPLPVETPREKRQSVYAPLN
2) LMDLDFDYASSGSEMSSDEDENGVITIQQLTNT
3) LPHKHSVSPNNHHTTSATTTPLHKSSPLLNYVTKNSPDDSLNNHTMLPEQNIIYEEXNGRTSDLGKNEHLLSPMETAHLDSNEALLQIDPMELPQISQKQEIGVPPLESQQAQQNENDFGISVSSFDAENNNTDSDMKDLFGDDDDEDVDXDDNEELNRANTETSXHVAENMPPQVGSPDIPLLNIHEQHDSSSNLTKTAEQASKSVPSSTLP
4) TAKHPVMLYKVPAEQPAPTSTEALFEDQDRAY
689
805
465
870
719
837
677
901










Molecular Recognition Features






MoRF SequenceStartStop




1) QKRINLSTVWPN
64
75