<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10286

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSIVDPELIAPLTKISDYLLSIRPGKVSAENIKRISSYYGFETFAEDNLIDDSTNNLINRLTIAGKIILIDIDFGTSFNTVLKVSLSLALNNSSGDNNNNTGKLSIVDKSLKPNCDDILFSNLDVGSFNKDGFDQSSQLAKFNANLKYLSNLDKLSIAKFDLFNYLDNLSICLKDIRDYQLNNGEEFLIKNDFLNEKELEQDLNNGYIGIGKYMINIYSRLGIFLKIWQDERFLINEDNDKSHYIYFGVKELDHNVTNSTIVSNINNNEKWWTAEFGWTDFQKIDKLNAGLNLFFNPTNEEQNVVVPESLMIKWGVRHYEQEEDPDEFSKFMIKFFNNNIVLKKLSSGKLDINLKLLLGSKLICLKSLVFPNPSLLQEFFQDLRSWFLVNNLIRVLISKTGPVAEEVAAQAPPPATAIATSATTATAIVAPLLPTNTDVIKDDTKLSSFIEENAQLLHSAHSNTPQRPTLDVTFTNQNSSNDFLIFELKQNLKSNLPSKIQLKIENGYLSYNISQNEQDQQDQNQNKLETKFIKSIIKTEDIIKVLQSI
Length550
PositionMiddle
OrganismPachysolen tannophilus NRRL Y-2460
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Pachysolen.
Aromaticity0.09
Grand average of hydropathy-0.283
Instability index32.15
Isoelectric point4.97
Molecular weight62370.90
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10286
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.66|      22|      42|      45|      67|       1
---------------------------------------------------------------------------
   45-   67 (32.77/19.18)	FAEDNLIDDSTNNlINRLTIAGK
   89-  110 (36.90/17.99)	LALNNSSGDNNNN.TGKLSIVDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     297.27|      71|     205|     121|     192|       2
---------------------------------------------------------------------------
  121-  191 (118.22/54.45)	FSNLDVGSFNKDGFDQSSQLAKFNANLKYLSNLDK..LSIAKFD..L..FNYLDNLSICLK......................DIRDY.QLNNGEEFLIK
  192-  237 (54.81/22.64)	...........NDFLNEKELEQ.........DLNNgyIGIGKY...M..INIYSRLGIFLK......................IWQD.......ERFLIN
  239-  327 (66.78/29.05)	..DNDKSHYIYFGVKELDHNVTNSTIVSNINNNEK..WWTAEFG..WtdFQKIDKLNAGLNlffnptneeqnvvvpeslmikwGVRHYeQEEDPD.....
  329-  391 (57.45/21.91)	FSKFMIKFFNN..............NI....VLKK..LSSGKLDinL..KLLLGSKLICLK.......slvfpnpsllqeffqDLR........SWFLVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.02|      21|      22|     485|     506|       3
---------------------------------------------------------------------------
  462-  492 (25.20/15.27)	HSNTPQRPTLDVtftnQnssndfLIFELKQN
  494-  517 (29.82/14.19)	KSNLPSKIQLKI....E...ngyLSYNISQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.17|      21|      22|     414|     434|       4
---------------------------------------------------------------------------
  398-  418 (32.63/27.26)	ISKTGPVAEEVAAQAPPPATA
  419-  439 (31.54/26.08)	IATSATTATAIVAPLLPTNTD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10286 with Med1 domain of Kingdom Fungi
Unable to open file!