<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10282

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDQDDNLGKQVQEKEALSTTLSGVASASIAAPPIPHITTNIVPLSTILKNYSEHSYKELTQLLITLQSTTTSDLFRENFIRLYVLTKWSRYAENFTKLIDLLNWLRMIIESISSNPIWGLKNLSNSLTSAKLPNPDLITALEVLVKGRPQLPSYNFIKQDSLSASTILKTLKNLNVILSLRLSLIQSLPKKFYNYTVKDGRCYFNIPKGFQCCVSLANDDVNNSQFFLIDFKFNFIFKDNIIVYNDEITKLPTVTHERVENLSNQLLQANRLNSSGGLNELYKFLHNFTLNYKLYLIHRQLILMRIGYWKSQINHTYNADKNIIIINYWVKSTQKKNAKSYFELSVLNDELVLKWIKDGILIETIQTFEDENEFCIEKIVTKFTEEHVKKLMFSIYDELLVLTNDNTNKVQIKETDNTPQLMLELLSMKFTTFSISPLSGLIYFINPSPLVASFVTLLNQDLQENLNKLAIRLLSLSLETRVERLNSMMSSTGWFQSKIVKLSGEEESKLTSTKLLNSIQYFKRKDWPQGWFLVASINVNTTDNLNWFVCRIKSYLGNWSIQWYEKLDILSLLKNTNDTADGLVDHDTLSALAELSTSKLLSHIIVEELENSGAKLKMINSNIKKGILDLFMEDGNLDSKEPFLIVENGSFFKIPNASSSIFIKIKLLSSNNLKIVIYGRLKNFKMNSLNETIQERNQNDDDMISEENSQQDDQEQASLNYDSSTSIFKIISIVNGNFITSNNVNSINAINNIPNVMSSINNNRKNTHNNVGNNSNRNIVNNHNVNNNKVLKNSLRLISRFSKIVTLIQNISTEESVKIIRNTLKTIEFQYGGDDQKTAPQTATLSILDPINKSGSKRSFAPKFSSLASNFELKLSESNPHQISLLQLTNLMNKVGILPMLKVLKLTLPIVESLSCLNKFKDDMVFINEDDTLKKFPVLTFRPLCYESNLFNILYNVMKPSEPTKRKAKKSTGNNMENQKTYEKLSFSLTIELKNSRNKDIIYLHSQTSATSSLQYQPQILKDIFSGKIKFPNSIPLDSGIACEYKNCYDLINWIHDKICTYYLGLKDEDTINSTGTVAIGNSNNHDQSSINNNGIKV
Length1098
PositionTail
OrganismPachysolen tannophilus NRRL Y-2460
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Pachysolen.
Aromaticity0.09
Grand average of hydropathy-0.273
Instability index32.11
Isoelectric point8.74
Molecular weight125232.98
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10282
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.47|      16|      18|      75|      90|       1
---------------------------------------------------------------------------
   63-   78 (23.61/14.56)	LITLQSTTTSDLFREN
   79-   94 (28.86/19.62)	FIRLYVLTKWSRYAEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.73|      17|      17|     748|     764|       2
---------------------------------------------------------------------------
  748-  764 (30.92/16.33)	NAINNIPNVMS.......SINNNR
  766-  789 (24.81/11.55)	NTHNNVGNNSNrnivnnhNVNNNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.36|      13|      15|     518|     532|       5
---------------------------------------------------------------------------
  518-  532 (16.87/20.87)	SIQyFKRKDwPQGWF
  536-  548 (23.49/12.74)	SIN.VNTTD.NLNWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.21|      22|     302|     156|     184|       6
---------------------------------------------------------------------------
  123-  144 (35.36/20.47)	LSNSLTSAKLPNPDLITALEV.L
  162-  184 (28.85/13.52)	LSASTILKTLKNLNVILSLRLsL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     159.63|      56|     194|     214|     281|       8
---------------------------------------------------------------------------
  214-  281 (75.64/79.89)	VSLANDDvNNSQFF..LIDFKF.NF.IFKDNIIVYndEITKLPTVTheRVENLSNQLLQANrlnssggLNEL
  410-  469 (84.00/53.91)	VQIKETD.NTPQLMleLLSMKFtTFsISPLSGLIY..FINPSPLVA..SFVTLLNQDLQEN.......LNKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.26|      13|      14|     661|     673|       9
---------------------------------------------------------------------------
  661-  673 (20.50/11.13)	IFIKIKLLSSNNL
  677-  689 (22.77/13.29)	IYGRLKNFKMNSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.89|      32|     195|     791|     827|      10
---------------------------------------------------------------------------
  791-  827 (45.32/33.77)	LKNslrliSRFSKIVTLIQNISTEESVKIIRNTLKTI
  993- 1024 (54.57/30.40)	LKN.....SRNKDIIYLHSQTSATSSLQYQPQILKDI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10282 with Med14 domain of Kingdom Fungi
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