<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10274

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSRMIELSELNPLLQSTNYYAVGRSTEVRYYVYEYIVEEDGEDTVPINMIYQYEFAIRSKLPSNMLLLVHTKDIYLYDLNCQNEEAESGDGVENAVAAIIDEEKMKLSLVSKGSFNSKASFQNQVPRPPQQQQQQLQNKIYINFLKAVKRFFIWRLSEHKGKELKDQYIVPFGNNTIALANFEKEKAETFFYKIMIVEPMFNFNDQVLVGLSLKDYRFQKIDDKTENFTNDDYSIYLAPSGVRVYLAADSLDSSLLNEAPTNYPKLVTFLKSYCNIDLSTKKNSKFLKVIPNLSHLNNLTPAISNSLRDYNSNLKYLIWPLDYCFIQRGIDDTTDKDYDDNQSLMGNPFDLIEDFIKFNESLELDKKKEAEARSAVNTPMSFTAVTPTVHTNNDENITENNNLQSVSETKQSQFASESTENPQPHDGDGGENVENWDEELFGDYYDDDEIQKKVTEDDFDFFDDSREKADQQKTNNPNGNENEIDGKTESSIANSKAKTLNLDEEGIDDVTQVKNEFASEENRDNLNDNEQKENVSFINTKEFEKAIGSASSTFYEDPGAPAPLPLPIIKTPQTPNEDLDKSPADKKKSVFAPLNFNPVIEEKIDSKYSIGGKFYVPTDNDIDITNENVSTATIHNNSGGNNSNSMNHSFELHDPRSLAIATSSLRNDKFDSNADESQSSSSSDEYIDSNEEYEEENEEPSSRDEAILGANIFSDTNSAMSAYGGDKLTNLTISSPYKKSDLTLQNSPQISSQKFSSHNSGSQSRSYSHSPAAVSTAENQNWLPFLLKLVPNHTIPSTFLYTSPTIKYDEAEEVSLILAKNFVFDCFNQNYATAPTGFAKLNLNRDHLVNIDDELEGMVNDTFPGITRVPLYEILESTRQDNNEDRNGKENYEVLTGRGRTIVKEEENQDLERLEYTDSLFGASSPITSSQHNPDYVSKGANKKLTIPELTMKNHLFKISQPTINLKRLDQDLKANFTSLNFWNLLNLQPIGDQHDFEINMILPTIINSGNIVDEYMARSSDFLASIIENYKSSRLGRATRFKFSSDESQKLEIEGARFSGGIYQIFIEKEKATNEDKFWQVVNAKSLEFAKALQERILRVRETQQEKHCSPAEMDGGETTQFFDKPILLLLANPFDSIQSYVNISKIIHNFKKKVTTYSFSGNFDDSLSKKKKRKIESPSAEQIMKLPLKIFEKIVPIDLYCPNGQSFSVISNRKLTRISLSLYNLCPSSCKDDSLLHDSSFMDDAFTTISPDLPKKIGFRITKTSIIKSLISEDLFVHVAYERSVDKRWCVATWTDQYGTVRNMKCWYCPVSQFGNKENHQRNSRFKTFEQISNEIWDISLKYVNSHNGKSHLVLTRLNNVIPDDELLHWKRLSLNTKNLFLIVLTVNVNSNFLFNYNESSLQSNSQLLFPGSQSLLSNKFVKKFKPPNSVGSTNSGFTPFLMNDSPENFNINSNVATTPSEMYSPNAAINSGLISSVQNKQFQNFEDVSIIDITNEAYGIVLPNPVPLSNQPNRISIKTGYLYKVVLDVYNDDVVTANGNNHESMNEQPPYGDPNMITSARVSVSLSNGKIPKFKNSNLLEVNLMSCPSLINSFDLIKTILTQYRSLSNLGTSWGINNSKNQYDDENENVLIPWHILAVRKALNGLVHVRVE
Length1656
PositionKinase
OrganismPachysolen tannophilus NRRL Y-2460
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Pachysolen.
Aromaticity0.09
Grand average of hydropathy-0.595
Instability index43.10
Isoelectric point4.97
Molecular weight187780.94
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10274
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.52|      28|     305|     549|     579|       1
---------------------------------------------------------------------------
  549-  579 (47.98/37.56)	GSASSTFyedPGAP.APLPLPIIKTPQTPNED
  858-  886 (47.55/28.50)	GMVNDTF...PGITrVPLYEILESTRQDNNED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     219.36|      74|     628|     922|    1005|       2
---------------------------------------------------------------------------
  922- 1005 (111.43/101.77)	FGASSPITSSQHNpdyVSKGANKkltIPELTMKNhLFKI...SQPT.INLKRLDQDLKANFTSL.NF...WNLLNLQpigDQHDFEI.NMILP
 1555- 1637 (107.92/69.48)	YGDPNMITSARVS...VSLSNGK...IPKFKNSN.LLEVnlmSCPSlINSFDLIKTILTQYRSLsNLgtsWGINNSK...NQYDDENeNVLIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.05|      60|     305|    1136|    1227|       3
---------------------------------------------------------------------------
  349-  408 (102.21/54.77)	PFDLIEDFIK....................FNESLELDKKKEAEARSA...VNTPMS.FTAVTP.TVHTNNDE..NITENNNLQSVS
 1136- 1222 (73.84/98.31)	PFDSIQSYVNiskiihnfkkkvttysfsgnFDDSLSKKKKRKIESPSAeqiMKLPLKiFEKIVPiDLYCPNGQsfSVISNRKLTRIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.16|      12|     136|    1225|    1240|       4
---------------------------------------------------------------------------
 1225- 1240 (19.65/20.99)	LYNLCPssckDDSLLH
 1361- 1372 (23.51/12.54)	LNNVIP....DDELLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.75|      21|     136|     323|     348|       5
---------------------------------------------------------------------------
  216-  236 (40.16/19.09)	DYRF.QK.IDDKTENFTNDDYSI
  323-  345 (32.59/31.90)	DYCFiQRgIDDTTDKDYDDNQSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     140.61|      55|     572|     463|     519|       7
---------------------------------------------------------------------------
  463-  491 (35.44/12.53)	.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FDDS...R.EK......ADQQKTNNPNGNENEIDGKTES
  492-  519 (22.21/10.33)	SIANSKAKTLNldEEGIDDVTQVKN.EFA.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1032- 1061 (27.84/ 8.44)	.............................seenrdnlndneqkenvsfintkefekaigsasstfyedpgapaplplpiiktpqtpnedldkspadkkksvfaplnfnpvieekidskysiggkfyvptdndiditnenvstatihnnsggnnsnsmnhsfelhdprslaiatsslrndkfdsnadesqsssssdeyidsneeyeeeneepssrdeailganifsdtnsamsayggdkltnltisspykksdltlqnspqissqkfsshnsgsqsrsyshspaavstaenqnwlpfllklvpnhtipstflytsptikydeaeevslilaknfvfdcfnqnyataptgfaklnlnrdhlvniddelegmvndtfpgitrvplyeilestrqdnnedrngkenyevltgrgrtivkeeenqdlerleytdslfgasspitssqhnpdyvskgankkltipeltmknhlfkisqptinlkrldqdlkanftslnfwnllnlqpigdqhdfeinmilptiinsgnivdeymarssdflasiienYKSS...RlGR......ATRFKFSSDESQKLEIEGARFS
 1066- 1118 (55.12/23.57)	QIFIEKEKATN..EDKFWQVVNAKSlEFA....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................kalQ.ERilrvreTQQEKHCSP....AEMDG....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.10|      43|     870|     598|     648|       8
---------------------------------------------------------------------------
  598-  648 (66.60/57.69)	NPVIEEKIDSKYSIGGKFYVPTdnDIDITNENVSTAtihnnsGGNNSNSMN
 1508- 1550 (76.50/45.95)	NPVPLSNQPNRISIKTGYLYKV..VLDVYNDDVVTA......NGNNHESMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.45|      40|     110|     687|     732|      12
---------------------------------------------------------------------------
  687-  732 (57.00/50.33)	YIDSNEEYeEENEEPSsrdeAILGAN.IFS..DTNSAMSAYGGDKLtNL
  802-  844 (61.44/35.85)	YTSPTIKY.DEAEEVS....LILAKNfVFDcfNQNYATAPTGFAKL.NL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.04|      22|      35|    1431|    1454|      21
---------------------------------------------------------------------------
 1431- 1454 (37.31/26.92)	PNSvgSTNSGFTPFLMNDSPENFN
 1469- 1490 (38.74/21.56)	PNA..AINSGLISSVQNKQFQNFE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10274 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ATSSLRNDKFDSNADESQSSSSSDEYIDSNEEYEEENEEPSSRDEAILGA
2) AVNTPMSFTAVTPTVHTNNDENITENNNLQSVSETKQSQFASESTENPQPHDGDGGENVENWDEELFGDYYDDDE
3) DNDIDITNENVSTATIHNNSGGNNSNSMNHSFELHDPRSL
4) GSASSTFYEDPGAPAPLPLPIIKTPQTPNEDLDKSPADKKK
5) KKVTEDDFDFFDDSREKADQQKTNNPNGNENEIDGKTESSIANSKAKTLNLDEEGIDDVTQVKNEFASEENRDNLNDNEQKENVSFINTK
662
376
620
549
453
711
450
659
589
542










Molecular Recognition Features






MoRF SequenceStartStop




NANANA