Description | Mediator of RNA polymerase II transcription subunit 31 (Fragment) |
Sequence | VPTRWEIELEFVQSLSNLQYLNYLAQNKYLEDESFLNYLNYLEYWRQPSFAKYLVYPNCLHILMLLKDKSFRDSILRQDIASLIMNDMVDRWKED |
Length | 95 |
Position | Middle |
Organism | Pachysolen tannophilus NRRL Y-2460 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Pachysolen. |
Aromaticity | 0.16 |
Grand average of hydropathy | -0.374 |
Instability index | 66.32 |
Isoelectric point | 4.89 |
Molecular weight | 11663.22 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364129 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription, DNA-templated GO:0006355 IEA:InterPro |
Binary Interactions |
Repeats | >MDP10270 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 53.98| 14| 19| 37| 50| 3 --------------------------------------------------------------------------- 37- 50 (28.51/15.70) NYLNYLEYWRQPSF 58- 71 (25.46/13.45) NCLHILMLLKDKSF --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ILRQDIASLIMNDMVDRWKED 2) YLNYLEYW | 75 38 | 95 45 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab