<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10261

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTYLECVDGKTWQLAPPTCFQIASFDKAVTASKKDSSDIHQNQTQHRQHPLPSSNRNDSTTLISNVLFSNTGWDLFVADDDGHVSILVTGIKKQIQHQQDVPQPPGLSNSAAPNTSQSPPLQQTLANSYSTTQYSRTSFNTAELLYSDNTTLPLPSLKTHTSRRLNKMVTVKWLNIDKQVIANSPAVKVQATSEQPVLNGCASKLGAAVQDSNGYYYSYNAQQYKSYGTMHPLSTKQACIGVRRSGEVCLWHQEDHGIEYRRVTAHLDLDQGDEILYASIGFKRDGKVIVGVSCPGSNSVKLFEIFIDWGYLLDAAKNLPKMPTYRTPDNMRFPPKLIVTKLFEIDVNDTDSSCSRLTSIDFISPNYHQSTEFDVLLTFENDGHYGSKAVDVENKSPSKSTILRYHLEDINQEDFVRSAFKTIANKRNIDSSSTSLSAMNKKTISKLVFKQKMTFNESIICIESLNLDMMICISFANGMMEVFNRSTMKQIKNIYSEPSSTNTDDSLLPSLIFSLFDAGFEFPRMNFQPEYTCISPNICCYIALPVDSSQLYIRSVESVTTKENTPPNKKGLLLATTAAIALRHTSACYFGYSTDDLMATIRSEIDSTEKRTNANQAYRLLISILQECQRAINLTIDISTEQTDKMLQNQPLQRILTLQLSLGTNLNWKRNKSGKIAWALVNLKFVTSSIMYTIHTIYSNMQRFAKKGLNTPDTLANARAREESIISVLGIIRWCMDYIIGLNQELLTLATVFKSGDTKKIEKCIADSIMVPLILGKVPRAFLIFAISNIRRLFSFVQKFVEKNDPWLTSLITPENQMGAFSYVEKQMLIVDSPISLPVMPTYKSGSASGSSLSNGMGSSSSTSSAALTRSLVAHPTMEAYYRLGAVLNNSPVSLNVFEKFLTEADVPLRNMRLDQSTSLAIEQQIVSQGYISKTFVEPLKKLCDVYEKSVLIAGNVDVTELYFRNVSWLKLGINGDDDFEEGDDDDDENNNNDFTDYSMFGKYNKKLIESNSYDGLLVDTLRKRLLKPIDFIERAEKSSNGNMNGSPATNIGNLSGEYSSINTLAMRRCIRCGAISSVNEVSTSVKDEDATLSAVTFVSNPVFTHYQRICFCGGAWANM
Length1120
PositionTail
Organism[Candida] arabinofermentans NRRL YB-2248
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Pichiaceae> Ogataea> Ogataea/Candida clade.
Aromaticity0.08
Grand average of hydropathy-0.272
Instability index47.52
Isoelectric point6.53
Molecular weight125007.52
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10261
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     251.99|      79|      89|      58|     145|       1
---------------------------------------------------------------------------
   58-  145 (120.00/107.17)	DSTTLISNVLFSNTGWDLfvaddDGHVSILVTGIKKQ.......IQHQQDVPQPpgLSNSAAPNTSQSPPLQQTLANSYSTTQYSrtSFNTAELL
  148-  233 (131.99/91.05)	DNTTLPLPSLKTHTSRRL.....NKMVTVKWLNIDKQvianspaVKVQATSEQP..VLNGCASKLGAAVQDSNGYYYSYNAQQYK..SYGTMHPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.78|      34|      60|     808|     843|       2
---------------------------------------------------------------------------
  808-  843 (54.79/49.61)	LTSLITPENQMGAfsYVEKQMLIVDSPISLPVMPTY
  868-  901 (57.99/44.48)	LTRSLVAHPTMEA..YYRLGAVLNNSPVSLNVFEKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     180.47|      61|     102|     558|     628|       4
---------------------------------------------------------------------------
  558-  628 (88.76/80.21)	SVTTKENTPPNKKGLLlaTTAAIALRhtsacyfgYSTDDLMATI...........RSEIDSTEKRTNANQAYRLLISIL...QEC
  661-  735 (91.72/58.73)	SLGTNLNWKRNKSGKI..AWALVNLK........FVTSSIMYTIhtiysnmqrfaKKGLNTPDTLANARAREESIISVLgiiRWC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.26|      32|     482|     425|     461|       5
---------------------------------------------------------------------------
  425-  461 (37.42/47.74)	NKRnIDsSSTSLsAMNKKTISKLVFKQkmTFNESI..IC
  911-  944 (51.84/36.78)	NMR.LD.QSTSL.AIEQQIVSQGYISK..TFVEPLkkLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.64|      17|      60|     334|     360|       6
---------------------------------------------------------------------------
  301-  322 (24.02/17.09)	KLFEIFIDwgyllD...AAKNLPKM
  341-  360 (24.61/16.67)	KLFEIDVN.....DtdsSCSRLTSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.85|      11|      39|     238|     248|       9
---------------------------------------------------------------------------
  238-  248 (21.12/12.36)	ACIGVRRSGEV
  278-  288 (19.73/11.10)	ASIGFKRDGKV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10261 with Med16 domain of Kingdom Fungi
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