<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10257
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MADASLSPPPIPHISANVTSLSTILERQSLNTYKQLKEFIITLQSNSQTDNVKKMNFLDLLVHIRENFVRIYVLCKWARNSKSIEKLIDLFVWLREQNQLITNALASVGTVKQSLVSAKLPNPDLSTAMEVLIKGGPQLPTYNYLPQKPLNPELILKTLRYLNVELATRMALQEQLPELLYNYKIQDGRVIFRVPNAFEFSISIADDSPDAKFFLVDFKLGFQSKDNELVPSVTSLPRQTFHNLEKIKLENLGCKLKIADKNNPGVKSFMAANFGLNLDDQEKKEDNSLIVLDNKSLFDIPNCRESLVMSITIESNQLDISIFGKLQNELKLSDISFTYDKNNSIQLNPMTSIFEVNSKINLAEKLKFNSGLGTALSTFSITSGSSEVSILGDSLLVLNKLSSLLSLLQLISNDQSLKVLDISLTEMSFQYGSTKDESIKLIILSENQDSVSIELPEGNPHRYCSKYLNNIVSNDFARIKNLVVYLKLSLPLFKAYDSLISENNAIMQKFIEANALPNLDIGNLKLSPSNGFELNLYDFEMLKISYYRAIDKKIEKKLRYEKYRVNLTVQMRHKTPALSLKKSLFVVQLDTSISDLSSDENVKMFNEKVVKAVGKYFTGEKQITLKSPGESTLVYLRNSVVCDYKCVEEVIGFLHGVMKNVVLDEKL |
Length | 667 |
Position | Tail |
Organism | [Candida] arabinofermentans NRRL YB-2248 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Pichiaceae> Ogataea> Ogataea/Candida clade.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.131 |
Instability index | 33.67 |
Isoelectric point | 7.94 |
Molecular weight | 75361.23 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP10257
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 71.37| 23| 28| 120| 147| 1
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120- 144 (34.93/38.47) LP..NPDLSTAMeVLIKGGPQLpTYNY
159- 183 (36.44/19.20) LRylNVELATRM.ALQEQLPEL.LYNY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 76.44| 26| 27| 352| 377| 2
---------------------------------------------------------------------------
352- 377 (41.37/24.98) SIFEVNSKIN.LAEKLKFNSGLGTALS
380- 406 (35.07/20.06) SITSGSSEVSiLGDSLLVLNKLSSLLS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 90.11| 30| 96| 315| 347| 3
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316- 345 (53.95/31.50) NQLDISIFGKLQN...ELKLSDISF.TYD....KNNSI
469- 506 (36.16/11.07) NNIVSNDFARIKNlvvYLKLSLPLFkAYDslisENNAI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 53.59| 18| 33| 46| 67| 7
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46- 67 (21.64/27.94) NSQTdnVKKMnfLDLLVHIREN
80- 97 (31.94/21.18) NSKS..IEKL..IDLFVWLREQ
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