<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10250

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceMFKLDDLNPLFKPPSALVKPSYGLEGSQAGNSNPPFDERQLTETNYYKLATTSKINCYFYQVQDFPTAQRSSLAPTTSPTDSKQGSSNGTSDANASPLQQIHTYDSIIKAKLASDYSIRDTITYVAKREICIFQMEIREHDANSDIGFNQLKDAIDNIINENKIHLKLVSATRFDSNAVLKQLPPQPANRPINIIYLSFLRAVKKYITLRLTKVHRLPDTSVDILPFGNQMIVSSTVEKPTEGSTCKQLNDGSYSILKMSPSLGFRNDLMLNISMSNSLKLYKLSEFLNTESFMDRKDYVIYICPSGVRCLCAINNSLADSITDEAPINYDRLVKLLEQHTTINLPFNDPNRKPPICRKWIKLIPNINHMNGLTPKISKYLESFILNTKYIMWPVELCFVQFSADSAKFQTTPLPKSRGDNGLEIENPLALIEDFIDLSNSDSIARELLQTDSVMEDVAQTSPAADVENEDDDWDELFGGEAEEGADVLEEDHEDNDEGSAANQLKSNSTDAPSNSKDLTPFPGAVLYNPVTNPLYEDPGAPSPISFQIFAPSTPPNETPATSIDENKAFTPKDANKSIFAPLNFNPLIEKDIDSKYSNGGKFFVKNGTESPILALPTKDSMSASATTPTFWRTGNLPSKRKFGESTFEDKATNSDLISDTESLSNELDVRPDDSNHGLGLGIASGGPVNSSFMNGGLSTTLGNTGILSSAASSMTPNISSAVFSSNTVAVPSPVTTSLTQDANEIQNWLYWILRGPSTSTIPTYFLSVSNPHISPDKLASILPILQELILFSPLDICTKDLSIMSRNRENPSMLNPEVESVMDSVFPGISKMKLHEILECSKQIEAAVPFECLFRSDKNNSKIDKQHNQSQLIKQEPAARLEFDDPSFATTSPLMNMNSNPELETRRNASVSRDSNAVTNKMIAESTSSNSLFRVPSTIINSKRLDHDLKINQASLNFWKILNLQPVMGMKDFEVLFIVPKTFEFFRQKSIDFMDSVIDSYKDCKLGTIKKLKVDAVDLDGLLEIEATSEAEFWANIDIQLNEVAKNFQDEFISSKKTYTNPILLLFATPFTDLISIVKMSSAINTFNMTLTEKIIEQEPPSDEDKRKKRKKSTVQSKIMLPINVFHKALPMELYFSQAGSFSVCSDQQLVDLALKLYNLCPTTQASREMKKGDRFKDRDPFFTVAKDLPSKIFFMLTKTPIAKNLISDELFLHVCYERSIDKNWCVASWTDQYGSINYIKSWYTNAEIKGSKSFEQVSNEIMEITLDYTSTHNGKSYVILTRLSNMIPDDELTEWKRLSVQNNKLTLIVLTVELEPSTLILSHHQNATQSSKKDDIKEFYSVRYTVGSTNSQMPTPNFASSVNNKMESPEINNSMQTPSYDLITSPIDSASMMTGHHYAGSHNLQSNGVNAENQVLIELSDECYGVILQMAQPLSNQSIRLPLKTGFLINA
Length1453
PositionKinase
Organism[Candida] arabinofermentans NRRL YB-2248
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Pichiaceae> Ogataea> Ogataea/Candida clade.
Aromaticity0.08
Grand average of hydropathy-0.368
Instability index45.78
Isoelectric point5.11
Molecular weight162150.49
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10250
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.37|      27|      78|     958|     984|       1
---------------------------------------------------------------------------
  254-  279 (28.53/13.51)	..YSILKMSPSLGFRnDLMLNISMSNSL
  283-  305 (33.30/16.91)	KLSEFLNTESFMDRK.DY.VIYICP...
  958-  984 (47.55/27.08)	NFWKILNLQPVMGMK.DFEVLFIVPKTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     162.04|      36|      36|     512|     547|       4
---------------------------------------------------------------------------
  512-  547 (64.17/40.32)	AP.SNS.....KDLTPFPGAVLYNPVTNPLYEDPGAPSPISF
  551-  585 (58.04/35.62)	AP.STP.....PNETP.ATSIDENKAFTPKDANKSIFAPLNF
  595-  631 (39.83/21.65)	SKySNGgkffvKNGTESP..ILALPTKDSM..SASATTP.TF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.64|      51|      84|     311|     362|       5
---------------------------------------------------------------------------
  311-  362 (87.63/59.97)	LCAINNSlADSIT.DEAPINYDRLVKLLEQHTTINL..PFNDPNRKPPICRKWIK
  397-  450 (77.01/47.88)	LCFVQFS.ADSAKfQTTPLPKSRGDNGLEIENPLALieDFIDLSNSDSIARELLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.59|      22|      42|      35|      74|      10
---------------------------------------------------------------------------
   52-   74 (36.41/50.77)	TSKINCYFYQVQDfPTAQRSSLA
  759-  780 (40.18/14.87)	TSTIPTYFLSVSN.PHISPDKLA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10250 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LQTDSVMEDVAQTSPAADVENEDDDWDELFGGEAEEGADVLEEDHEDNDEGSAANQLKSNSTDAPSNSKDLTPFPG
2) YNPVTNPLYEDPGAPSPISFQIFAPSTPPNETPATSIDENKAFTPK
449
528
524
573










Molecular Recognition Features






MoRF SequenceStartStop




NANANA