<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10247
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MLSNFNASTPGQVGAPPTSAVPGSVKTYKNENTFIYQELLRFESGLQKLSASIQQYEPNPEIASALVSSMDSINNELNQLEILHDLKMNQVLKQNSENMQLNDNLRNILVSLDECRKELNELPKLSIEEEIELKKNKKNIELDEDSVAEIPKPDLEATKTLLTYAMKLAKFSKIPRTFDGYLMPNNFIWPGDDNMRRGMLATASMMPEKIIENENGTSDMNEDTTMNEASAVNNEQEDADDDEEDDELLPERRNENAGLYKADESDKTEKKDAATIMADLDLFDDESDYDE |
Length | 291 |
Position | Middle |
Organism | [Candida] arabinofermentans NRRL YB-2248 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Pichiaceae> Ogataea> Ogataea/Candida clade.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.797 |
Instability index | 50.30 |
Isoelectric point | 4.27 |
Molecular weight | 32903.11 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP10247
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 116.33| 39| 40| 69| 108| 1
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69- 108 (59.54/36.89) SMDSINNELNQLEILhDLKMNQVLKQNSENMQLN.DNLRNI
111- 150 (56.80/30.61) SLDECRKELNELPKL.SIEEEIELKKNKKNIELDeDSVAEI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 40.28| 13| 20| 211| 223| 2
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211- 223 (22.79/12.26) IEN..ENGTSDMNED
232- 246 (17.49/ 7.72) VNNeqEDADDDEEDD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 33.43| 10| 21| 259| 269| 3
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259- 269 (14.01/10.37) LYKaDESDKTE
282- 291 (19.42/ 9.96) LFD.DESDYDE
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