<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10234

Description Cyclin-dependent serine/threonine protein kinase
SequenceMALNSILTIGPFKHRKDLTRESVLSTYHIIGYIAAGTYGKVYKARLKSKKDKEGEGSQTAKNDGSRHDGDDKDIQFYAIKKFKSDNHLANKTHHNHDINGNEVVHYTGISQSAIREMSLCRELNNKNITKLVDIILENKSIYMIFEFCEHDLLQIIHYHSHPDVKPIPQSTIKSLTWQILNGVTFLHQNWIFHRDLKPANIMVTSSGVVKIGDLGLARKFNNPLQSLYTGDKVVVTIWYRAPELLLGARHYTSAIDLWAVGCILAELLSLRPIFKGEEAKIDMNNKKSVPFQNNQFQKIIEILGTPNLKIWPALNKYPEFVSFQQQLSGNYPSNLVNWYKMIGGSNKQCLSLLKGLLDYDPSTRLTADLALVHPYFLELPKVQENAFEGLSLNYPKRRIYSDDNDINSSQAIQNNYKRHGGGYDDANNGGSQANIANARKRQK
Length443
PositionKinase
OrganismSuhomyces tanzawaensis NRRL Y-17324
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Suhomyces.
Aromaticity0.09
Grand average of hydropathy-0.468
Instability index41.50
Isoelectric point9.23
Molecular weight50298.75
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA:EnsemblFungi
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IEA:EnsemblFungi

GO - Biological Process
negative regulation of filamentous growth	GO:0060258	IEA:EnsemblFungi
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
nuclear-transcribed mRNA catabolic process, non-stop decay	GO:0070481	IEA:EnsemblFungi
phosphorylation of RNA polymerase II C-terminal domain	GO:0070816	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi
protein destabilization	GO:0031648	IEA:EnsemblFungi
response to oxidative stress	GO:0006979	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10234
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.94|      30|      79|     314|     344|       1
---------------------------------------------------------------------------
  314-  344 (52.85/37.53)	LNkYPEFVSFQQQLSGNYPSNLVNWYKMIGG
  392-  421 (55.09/34.70)	LN.YPKRRIYSDDNDINSSQAIQNNYKRHGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     179.93|      46|      96|     114|     163|       3
---------------------------------------------------------------------------
   70-   97 (27.50/10.97)	.......................DDKDIqfYAIKKFKSDNHLANKTHHNH.D
  114-  163 (76.29/52.33)	IREMSLCRELNNknitKLVDIILENKSI..YMIFEFCEHDLLQIIHYHSHPD
  211-  256 (76.14/44.04)	IGDLGLARKFNN....PLQSLYTGDKVV..VTIWYRAPELLLGARHYTSAID
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10234 with CDK8 domain of Kingdom Fungi
Unable to open file!