<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10227

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMTDTIKNGTHTGGKLPADIPHITNNILPLSNILKFYTQEAYKQITTLIENLSSTKHSESDSSRKKTFLKLIISLRQDFIKMYTLVKWASNSKDVSKFIDLLNWFRMQEFHFEQLSFQLNALNSFSGAKLPNSDLITSLEVLLKGRPQLPSYNFLKVPKVTPEKTLEVLQDLNLILMTRMALTDIPDRFLKEYEIKDGRIIFSVLSEFQVAITVANDLVIETNEDYYKSPFYFVDFKFLFGINPETSLITHRHNKITTRLPQNSHEKLEKTVNTILLNQGLNGLYDLLHKYSISFKLYLIAKQLKDLVSNSKWKSSIQFNYQNGKSLIIINYWCGHYLSRNWKSFIEIGIDRSYNLNFRWFKNGGYVLDHGIVDIFKESLPSDSADEEEGSGEEESDLSVELILNTIINKHSEGLISSIYNQFTSRVSKSSTTQEDQISYISPLQLLIKLSPKKTTIFAINPATGYFYFIDPTPIQNQFTKRINSIPLKIQNKFFLSELDLINNVVESLVQLRLETYTKEIHNRLITTEWINNSIIKLNEYETGKLLSYINNISTNLTKIQFYRRKNWPSSWYLINLTNGITNSTHWWVSRIKSINGDWKVQWIQKLLLKDGDDDEPIMLDFRFFSSLSKLCSNMIIDHMILEELQLRNIKHLKVEKIDQVLKKFNLEDSDGHIEDKEASPNDPTPPSPISYESILLLYNDHLLPVYNSSTSLFLKISLINVNQQTQMKLKLFGNLRNLAIKNSEDKLIKIDESKKIFEINDLINLTSRMGGNGKSEDILEFSDTSSSSKNLLDLIFNNLNKLNELIKILDQLNKNNIRVLTNSINDITIKVDDNIEDLVIKLPEKSTDSITLAAHEFIKSDKDAEENELNLILIYMNRYLKDHASLATKKDAGTDPIVGIIKYFKEFNPIFKSIQSIHTLFNHSETMPLIGVHKMPKLNFDVKLPSLNQIQYMFYINYLSASGSKKTQNDKFVITLTFKNNKFEKGNTNIVKISLKDNLNSKNLKYKGLFELIFKAINEVDALTPSLIKLNYDFLVNVELVEEVMVKISKCFLVYAKAE
Length1059
PositionTail
OrganismSuhomyces tanzawaensis NRRL Y-17324
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Suhomyces.
Aromaticity0.10
Grand average of hydropathy-0.272
Instability index33.35
Isoelectric point8.14
Molecular weight122271.11
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10227
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.17|      26|      28|     546|     571|       1
---------------------------------------------------------------------------
  546-  571 (48.96/29.20)	LSYINNISTNLTKIQFYRRK....NWPSSW
  573-  602 (45.22/26.41)	LINLTNGITNSTHWWVSRIKsingDWKVQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.99|      37|     235|     219|     255|       2
---------------------------------------------------------------------------
  219-  255 (67.75/35.30)	IETNEDYYKSPFYFVD..FKFLFGINPETS.......LITHR..HNKI
  464-  485 (34.18/14.54)	.....GY....FYFID........PTPIQN.......QFTKR..INSI
  487-  534 (38.07/16.94)	LKIQNKFFLSELDLINnvVESLVQLRLETYtkeihnrLITTEwiNNSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.13|      28|      30|     894|     921|       3
---------------------------------------------------------------------------
  894-  921 (50.34/32.04)	TDPIVGIIKYFK.EFNPIFKSIQSIHTLF
  926-  954 (47.79/30.03)	TMPLIGVHKMPKlNFDVKLPSLNQIQYMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.69|      22|      28|     312|     336|       4
---------------------------------------------------------------------------
  312-  336 (41.65/31.53)	WKSSIQFNYQNGKSLiiiNY.WC..GHY
  341-  365 (33.04/17.41)	WKSFIEIGIDRSYNL...NFrWFknGGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.53|      29|      30|     734|     762|       5
---------------------------------------------------------------------------
  734-  762 (46.58/28.01)	NLRNLAIK.....NS.....EDKLIKIDESKKIFEINDL
  764-  794 (29.44/14.75)	...NLTSRmggngKS.....EDILEFSDTSSSSKNLLDL
  811-  838 (31.51/16.35)	QLNKNNIR.....V.ltnsiNDITIKVDD.....NIEDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.97|      43|     471|     135|     199|       7
---------------------------------------------------------------------------
  140-  156 (17.27/11.23)	...........................................VLLKGRPQLPSYN.....FLKV
  166-  198 (22.68/29.56)	EVLQDLNLilmtRMALTDIPDrflKEYEIKDGR................................
  659-  716 (62.03/27.48)	QVLKKFNL....EDSDGHIED...KEASPNDPTppspisyesiLLLYNDHLLPVYNsstslFLKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.69|      20|      29|      59|      78|       8
---------------------------------------------------------------------------
   59-   78 (33.06/22.11)	SDSSRKKTFLKLIISLR.QDF
   89-  109 (31.63/20.77)	SNSKDVSKFIDLLNWFRmQEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.39|      16|      80|     875|     891|      11
---------------------------------------------------------------------------
  875-  891 (24.26/17.38)	YMNrYLKDHASLATKKD
  955-  970 (28.13/15.48)	YIN.YLSASGSKKTQND
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10227 with Med14 domain of Kingdom Fungi
Unable to open file!