<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10221

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSLTDILSANTNFYQLAKVQEIKYLVCRATSEDQSLLDVEIQLRKENPKVLATLYPKELWSFSLDGSDPPVPNAQYKLKQSSIQTMDPRDLHKNNGPSNISSLVGATLVKALKKMLMTSLSIRKELTMFGTCGLLPESNDLIRIEPKLLDTGDILLSLTSQPHNLHHLGTLDDSIDVNSTHALYLIPSGIRCYVSGNTLQEAWTSKPQNAQKIIDILQAHHGISIDSTSSRWVKVIPNLQHLNGITTQVADYLKPVSNTKYISWPAELCLVQRCEHIEKSDDPNALDDFDPMSLIDDFVQLKASAATKTPSNVPTTNNTPADIGNVQPSNGPPTSKPTPTNTSAPLTTATTITANALPEESVNMDESVHDDWDDLDAELFGGDEITDADFDLFDEPDTATKRDGQDDNDDDVDAELEEALNDALMGEDLNHISFEHDETDREKSDDLKSDGKNNTRETTKNPYDIPIHEITIPNTPPYEDPGAPLPVLSPRGQRKRSIFSPLTFNPIIKSNVDNKYANGGKFHVSTVDTPVGDFGIPNVPLAEGFGIGQDEGDSGESDSSDYIEDSGTECETDDIIVPPTRINSRESSLDSANLNISSQNEVTERGISLEPESKNKRFITPGVQLDGTISENSRPSSPSTNGTGEPNPLPFLVRCLPVSTMPEHFYKENPTVSDMNTLDQLIQQIVWDDACLEDTFPKESEYENVSSDNLKRAIAQIFPEFRGISLAEFSDVTPKEVNSPFASFKANDYLPKNSQSDFSTSPKKESTDDNKLIFPIPEPKVKVKRLNEEIIVNSTALNLWNLMSFESLHGTKDFGIIMVAENEPFELCEFFVQAFIESYHKSNLGSVEKIVLDGFVEKGIVNANSDLKVVFTKLHEHLVQQKEYREILVFMTDSEENLKSIVKKVTLFEKIKEWCTGSSNGTLLPIKVSLKVIPTSFVVNNGVFSVLSISRNTRLALSVYNRLNQTNRTFADLSNAFPKKIKFQLTQEPVAGRILSEESFIHLAYERSIDKNWCVASWTDDKSTFHEVKAWPLDVKEKSSLENVMNQLWDTTLELSKNVKGKKYLVLTRLNGGIADDELLQWKRLASKALFLTLVIVSVNTNSRLLLKLDQSSFPLNKLFSQENGFDSNSSMTKFESCPTAGSSTGLTPSIFTPQQMNSPDIFSISRAAAHESPSEKFTDDNTVLQDISDLVYGLVIDSPMSLSHSPGRAVKLGFLVKPIENSNNKLKCFEVGILSSPSNLSSGELMYQLLHQYRNLAKMGEIYSTVGNPVETIVPWHIAAVNKVMKCLLHVRHEIDNKQVG
Length1302
PositionKinase
OrganismCyberlindnera jadinii (strain ATCC 18201 / CBS 1600 / CCRC 20928 / JCM 3617 / NBRC 0987 / NRRL Y-1542) (Torula yeast) (Candida utilis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Cyberlindnera.
Aromaticity0.07
Grand average of hydropathy-0.408
Instability index40.82
Isoelectric point4.87
Molecular weight144594.78
Publications
PubMed=27535936

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP10221
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.87|      13|      16|     310|     322|       1
---------------------------------------------------------------------------
  310-  322 (25.72/12.01)	PSN.VPTTNNTPAD
  328-  341 (22.15/ 9.32)	PSNgPPTSKPTPTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.43|      42|     138|      99|     140|       2
---------------------------------------------------------------------------
   99-  119 (21.47/ 7.59)	.................................NISSLV.GATL.VKALKKMLMTS
  120-  152 (49.62/26.67)	LSIRKELTMFGTCGLLPESND.......................lIRIEPKLLDTG
  156-  202 (40.34/20.37)	LSLTSQPHNLHHLGTLDDSIDvnsthalylipsGIRCYVsGNTL.QEA........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.79|      24|      30|     628|     654|       3
---------------------------------------------------------------------------
  628-  654 (36.86/31.32)	TISENSRPSSPSTNgtgEPNPLPFLVR
  660-  683 (42.93/26.95)	TMPEHFYKENPTVS...DMNTLDQLIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.68|      11|     504|     213|     228|       4
---------------------------------------------------------------------------
  213-  223 (20.21/20.90)	IIDILQAHHGI
  235-  245 (20.47/ 6.58)	VIPNLQHLNGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     162.36|      41|     504|     573|     618|       5
---------------------------------------------------------------------------
  358-  402 (49.69/23.73)	PEESVNMDESvhdDWDDL........DAE.LFGGDEITDADFD..LfdEPDTATKR.
  405-  456 (45.55/20.70)	QDDNDDDVDA...ELEEAlndalmgeDLNhISFEHDETDREKSddL..KSDGKNNTR
  578-  618 (67.11/46.55)	PPTRINSRES...SLDSA........NLN.ISSQNEVTERGIS..L..EPESKNKRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.96|      22|     504|     285|     308|       8
---------------------------------------------------------------------------
  249-  270 (37.57/20.83)	VADY..LKPVSNTKYISWPAELCL
  271-  294 (30.39/21.64)	VQRCehIEKSDDPNALDDFDPMSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.14|      15|     278|     533|     547|       9
---------------------------------------------------------------------------
  533-  547 (29.04/15.53)	DFGIPNVPLAEGFGI
  813-  827 (28.10/14.81)	DFGIIMVAENEPFEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.40|      75|     417|     692|     778|      10
---------------------------------------------------------------------------
  692-  778 (108.36/104.64)	LEDTFPKESEYENVSSdNLKRAIAQIFPEFRGISLAEFsdvTPKEVNSPfasfkanDYLpKNSQSDFSTSPKKESTDDNKLIFPIPE
 1116- 1190 (131.04/89.06)	LNKLFSQENGFDSNSS.MTKFESCPTAGSSTGLTPSIF...TPQQMNSP.......DIF.SISRAAAHESPSEKFTDDNTVLQDISD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10221 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AATKTPSNVPTTNNTPADIGNVQPSNGPPTSKPTPTNTSAPLTTATTITANALPEESVNMDESVHDDWDDLDAELFG
2) DEITDADFDLFDEPDTATKRDGQDDNDDDVDAELEEALNDALMGEDLNHISFEHDETDREKSDDLKSDGKNNTRETTKNPYDIPIHEITIPNTPPYEDPGAPLPVLSPRGQRKR
3) ESSLDSANLNISSQNEVTERGISLEPESKNKRFITPGVQLDGTISENSRPSSPSTNGTGEPNPLPFLV
4) GDFGIPNVPLAEGFGIGQDEGDSGESDSSDYIEDSGTECETDDIIVPPTRINS
305
383
586
532
381
496
653
584










Molecular Recognition Features






MoRF SequenceStartStop




1) AELFGGDEITDADFDLFDEP
377
396