<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10215
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MDSYHSDLTRIATILKQSPGSVTLENLLRLANFYKFETFNEEISPGVKRVSIAGKILVIDIDFHELESSIRGQTRIDVDTVKLILANNDSMFTVNNADGSIVLEMALKQQKLVQFDRCLEQLSVLDQNSTQVDLFHQYTSIMGTLQAEFPNSEYSTQEFSIMINSLFQISLASDERIALAFESVTVNDVGFKVEFSKPLIIPRHLANKVGIVLDNESRAQLCNNNDIYRTKRNSLLQTFQFVQSEFVQTTGFACGALSQLITTLHWFTKFESLNKLYTELHSKYEPLDRLSELTNEPQWFTEFTQGSLQKEDTFIKITVTDDEFRVDTELEYKRSIKLDALTPDDIRILSNELQREDSSP |
Length | 360 |
Position | Middle |
Organism | Cyberlindnera jadinii (strain ATCC 18201 / CBS 1600 / CCRC 20928 / JCM 3617 / NBRC 0987 / NRRL Y-1542) (Torula yeast) (Candida utilis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Phaffomycetaceae> Cyberlindnera.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.262 |
Instability index | 35.80 |
Isoelectric point | 4.80 |
Molecular weight | 41202.02 |
Publications | PubMed=27535936
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP10215
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 90.10| 28| 35| 243| 275| 1
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243- 275 (43.66/38.84) QSEFVQTtgfacGALSQLITTLHWFTKFE..SLNK
281- 310 (46.44/28.26) HSKYEPL.....DRLSELTNEPQWFTEFTqgSLQK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 58.46| 19| 35| 171| 189| 2
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171- 189 (30.71/19.20) LASDERIALAFES....VTVNDV
205- 227 (27.75/16.78) LANKVGIVLDNESraqlCNNNDI
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|