<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10212

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTIIRRDRCSNPISWSKNGFIAFAHHTSSTNLSISKLESLRGQSWRLSSKKSYEIKTASQTSCKPIQVVVWSPSGADLLVVDQVGGVSILGTGIVKNGNVHQLSCFEDVEILYQDDAGRCEDESLSKCVAFKWINVDKPVISSSPAVFSEEQNRYNYSVHQYKPYGFLHPNGKSGCFIARRDGSVDFYYQGITMEFKKHRIMLEPAREWVSQASIGFLRDGDVVVVCYCPKDQSLKVYKLSVSWNLKSCEPNFKVEKLLMERLNKIGSNGLTMELDQIEVISPNYSMDTDLDILIAFKGIGCNNRTLLQKYQISTVYKDLRFKTDGGTVEGFPNLVLKAEDYLDGELLDIELKNFDMNVIVTSAAGRVHLRSRKNLQLHIGASSTMSSLLDCGFEFPMTETNPDCIAVCPSMAGFVSLTSGVLEFHPVVRKSQNAWDAKDILKMSSGIAYLFCSACYTNTIADELIALILNEFSKLDPELRYEIIVTTLKESHRSLNFTLDISKEQIDRLLVNPPMQKLLSLQYSLGKFLPTNQQSTIALAILNLRLISFSIMVTLRTLFHQQQRIVNKGVSESLIDGVYRSESVLSTVGTINWLIDFVIFTIQELMKLSQSSGHESIIVTLLLSTVPRSLLIYSLAGVKKIDGVLTKVMEQHMQTPRPSSLNVEILQKSAERFKSLLELVELEHFEKFLMQIETLIPQEKENRLSVEQAMVFECKLTGNFAGLDSRLLSLFQQHYEEHPLSELFFHDTRWLKLDVAPNTIPSKVLLSNDDPVPIVIDLSTDLIDDVTKMVITNKEKLKRCLRCEYIRGDNDDVFYIMGKGITGSTNHWPVAYNRTCLCGSCWAYLSGDECSL
Length853
PositionTail
OrganismCyberlindnera jadinii (strain ATCC 18201 / CBS 1600 / CCRC 20928 / JCM 3617 / NBRC 0987 / NRRL Y-1542) (Torula yeast) (Candida utilis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Cyberlindnera.
Aromaticity0.08
Grand average of hydropathy-0.074
Instability index34.79
Isoelectric point6.11
Molecular weight96191.75
Publications
PubMed=26150016
PubMed=27535936

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10212
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.28|      45|      54|     242|     293|       2
---------------------------------------------------------------------------
  242-  288 (73.55/53.98)	VSWNLKSCEPN................FKVEKLLMERLNKI...GSNGLTMELDQIEVisPNYSMD
  295-  358 (62.73/31.40)	IAFKGIGCNNRtllqkyqistvykdlrFKTDGGTVEGFPNLvlkAEDYLDGELLDIEL..KNFDMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     234.72|      59|     132|     459|     517|       3
---------------------------------------------------------------------------
  459-  517 (97.38/62.45)	NTIADELIALILNEFSKLDPELRYEIIVTTLKES..HRS.LNFTLDISKEQID...R...LL...VNPPMQ
  536-  592 (62.76/37.72)	STIALAILNLRLISFSIM.VTLR.....TLFHQQ..QRI.VN..KGVSESLIDgvyRsesVL...STVGTI
  593-  655 (74.58/46.16)	NWLID.FVIFTIQELMKLSQSSGHESIIVTLLLStvPRSlLIYSLAGVK.KID...G...VLtkvMEQHMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.80|      21|      48|     166|     188|       4
---------------------------------------------------------------------------
  166-  188 (32.23/32.11)	GFLHpNGK..SGCFIARrDGSVDFY
  216-  238 (36.57/24.26)	GFLR.DGDvvVVCYCPK.DQSLKVY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10212 with Med16 domain of Kingdom Fungi
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