<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10199

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMRNENITWSKNGFIAYMAPTHNSKYNLFLTYLENIDGRTWQLAKPQGLSMKPNDDCELPHLSSIFWSNLSTDLAVCDDHGNFYILLAGVGLLGQNGEGKPTENGKKNSPSSNGNFPSYELTSYNHTEMIYRDIISPNLTGNSVTRSKFVAFKWLNIEKTQIINKPATFVNTDPQQSQQMPQAPLAYSYGVTQYQPYGACHPISTKQACVALRQNGEFILYFQGEHKVEYHKVSVPVLNKKIVSFTRASIGFDSKRIIATAYDSILDTIFSFLVDIEWGFLIESSKKQKVDPHYYTPKELQTPPKLNLRVFHQMRPRPLLEIEVQSVKNEDAMDIDDNDKNNDETRTTLSNLSSINIISTNFEEENQLMVFISYETLDEITLQKLTTIYRYSITKALDLISSAFVDLGLRKNISKPNGAITYELSLQDKLTRPNLIQSIDTAVAETFIIITYEDGQIDLMDRKTLSLVSNNQENKNSTPPTITTLFDVGFQFPKIERTSKNPLRVSVSPNLTSLVYTEVNNETQQLTLKVLEKRPECEISPKELFITSVGFAFRHAYSCYTNTCADDLVALIQTEIKRIGNSLAKAVATKESNLELILNRFIESIICESHKAINFQLDAFGKDSVDKLLSNPPLQKLLSLQLVLGELQQNSNHVISDLAWIVLNLRSTSFGIMFSLSSIYRQISKKKPAEDSLQDSITRAECIMSLVGNVKWLIDLMIYLNQELLQLAFVKNTNSTDTKLHYKNSIVLPIILSKVPRLFLMYAWSSIGKTHEILKKLHKDLSESNKLFTPMKEALNRYFTVCNTSPLNLSISENFLRECDAYVSKEIASRAANKDRGYALKIEQKLVCQGELSDDLVQIAKLLIERHSINISRDIKVSELFFYDVNWIDVGIAKNTMSRIENEDFFRSKNPVIHIDPKDQRTTIPRLQYNRIECIDALRKVVVKVGDKLNPNLATVIPKKNNNNKLAKLRKCTRCRSVSSVTDPLVFDVPSNVGLWTMVFQRTCICGSAWVNCEK
Length1014
PositionTail
OrganismHyphopichia burtonii NRRL Y-1933
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Hyphopichia.
Aromaticity0.08
Grand average of hydropathy-0.271
Instability index43.81
Isoelectric point8.30
Molecular weight115184.69
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10199
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     228.40|      78|     120|     487|     577|       1
---------------------------------------------------------------------------
  487-  577 (112.73/141.25)	VGFQFPKIERTSKNPLrVSvSPNLTSLVytevnneTQQLTLKVLEKRPECEISPKE.....LFITSVGFAFRHAySCYTNTC....ADDlvaLIQTEIKR
  612-  698 (115.67/98.47)	INFQLDAFGKDSVDKL.LS.NPPLQKLL.......SLQLVLGELQQNSNHVISDLAwivlnLRSTSFGIMFSLS.SIYRQISkkkpAED...SLQDSITR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     357.68|     114|     121|      44|     163|       2
---------------------------------------------------------------------------
   38-  157 (186.51/152.39)	RTWQLAKPQG.LSMKPNDDCELPH..LSSIFWSNLSTDLAVCDDHGNFYILLA....GVGLLGQNGEGKpTENGKKNSPSSNGNFPSYELTSYNHTEmiyRDIISPNLtgNSVTRSKF...VAFKW.LNIE
  158-  282 (171.17/120.25)	KTQIINKPATfVNTDPQQSQQMPQapLAYSYGVTQYQPYGACHPISTKQACVAlrqnGEFILYFQGEHK.VEYHKVSVPVLNKKIVSFTRASIGFDS...KRIIATAY..DSILDTIFsflVDIEWgFLIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.56|      22|     121|     330|     362|       3
---------------------------------------------------------------------------
  330-  351 (38.14/37.29)	DAMD......IDDNDKNNDETRTTLSNL
  457-  484 (32.43/11.98)	DLMDrktlslVSNNQENKNSTPPTITTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.55|      17|      29|     887|     914|       4
---------------------------------------------------------------------------
  890-  906 (29.91/35.46)	GIAKNTMSRIENEDFFR
  922-  938 (30.64/ 8.05)	TIPRLQYNRIECIDALR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10199 with Med16 domain of Kingdom Fungi
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