<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10198

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMSKLKNRNSLLSSHNRTSFSNSTKEEILSMKYLMERPDAALYPLNYQDAMKSGGDTTVANKKDDNSDSVNIYPDYEPWKDHNHLPSDKAESEKERMNNATFLNKGSFEAPQVSNEYYSSRNLIQATIFSSTANCNNILKELSQHLTNAYKTRDEVINKITYESNSFKIPPRVTLTTLKKESWLKDLANPNIPLLKISNKLPHGIKNKTLVDTLSSKNVPITRAIWFTKCTLYSELMILRRKIQSKQLTHASPHPNPRFGQSPEYIESQWLQEWTQQVVDYVYKFSKEMSYINSPEKKQLFNSKLGYLLTYLKTLYIECLLDKEYFISNILRFLRDGLPLEPQNISQMLAVNRSDNDENISDLFPIEITIDYGRTLVALTLVKIFWKEILKLDYLCKELSELLLFNYYFILKVPAHSTKSSHKTNEKTALPSNLKQKILLHISDSVEYLFKYNTNVFIIPNYWMLINEVLYNILLGSQSLNTNDQDREEIERQLKLINYRNESLMLNMRHLSQTSNSIEMAPPSSNNRLPAKRNSFLNASIGGLPFTVSPSTSNLNNQNNHAIQENHESGDHTFINRRNYDSLKIIEQFDRLQLNDELASYLRPKPDNWPNSNTWRSNLKLTIYWCITNNRDHRKSSEEILIICNFLKRNVLQKLSGKNTNNWKAEFENEIMEIIYEVVDKHDEEVNYYYLYVLINELYQLKVIAISSYLRKLIASGIFYITPGTNTDLPEGSKYNRQVDIHLSILRNLPVLNNKQCNSILQKWTPQGFNFNEKFEKGKQVLQEQIINKLLNNSFDDNIEQNMDYIKELNVGLKFMLVNWITTNLKNSISNSPRLIHVTPSIIANIYNFYSLCDNLTVFFKVFVRFILRNEGKIIIFYLDSLYFISKLIIRHFKLVKFIAGNNYESANTGYDLFKLTIINYKDLQNRDTDYFRFHDVWNFINRAVENSEATFNNGTSISKNNPLYAKEMVDSPMKIHMQENNKVNEKYSAEDFRNDLEVLIETPAKLMSQDEINDALSVIESMNVDVNAFKDLKRAKESVIIISEFMLKNGTHLNERQEISLFKLLINLSRILEAEQPLLFMDQLQTHIIESIKVTEEVQQLIIHFKKMLIYEVLQIRDLIMIFQKGFGNKDTGFQKKCNILIYDIFFETQTSLERQYLLNHQILFLEVLRYFYNIKDGTSELLIASKALKEDQKESIYQSYILENYKQGVYAVLKNSFFLHTKLTIDTLTKQLDTDSIIDICNDLLYLKANPISSKEDTFKLMKIISEFNLPIVQCLLKAITSKEFLTITEENLQETIEQFVEMVLDNLNFQFLSYNSYFGELFNYLNWRYKVKVFNTLENLFLCNTVFNFFSGEPTDLNKSDEDIYLRRKGSSMNLLPVFKDYFKKFSVSSMDDIPSSYKFFQDLSKFLLKLVHAVNSDVALENKNSGYLGDSISIFLRILIIHKISLTSIIVRHDGEQFTFIKNLISLLNSRFLSTKSEKLKILLYDLLLLMKSSLTTALIDINDTSLGDSTSPALNITNNMSPAPTDETIKMNVDGVPVNDHLNQPPYSKPSASGLPLVSSMFNLPEPNNTNPFKDCIDDSKVASSIMLDEQELTQDGDIHNVNNSDLILVSTRRDTVSFSSAFGLLEGSNVQQPTASRQFSLKSYQLLEEAGNAVNDGCINLLLFDAYTTKENIP
Length1679
PositionKinase
OrganismHyphopichia burtonii NRRL Y-1933
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Hyphopichia.
Aromaticity0.10
Grand average of hydropathy-0.339
Instability index43.35
Isoelectric point6.24
Molecular weight194537.92
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10198
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.06|      20|      86|     303|     326|       1
---------------------------------------------------------------------------
  303-  326 (32.06/28.41)	KLGYLLTYLKtlyiECLLDKEYFI
  390-  409 (38.00/22.66)	KLDYLCKELS....ELLLFNYYFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.27|      17|     491|     270|     286|       2
---------------------------------------------------------------------------
  270-  286 (32.41/19.41)	LQEWTQQVVDYVYKFSK
  760-  776 (33.86/20.61)	LQKWTPQGFNFNEKFEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.78|      19|      86|    1315|    1341|       4
---------------------------------------------------------------------------
  915-  935 (23.81/16.40)	LTIIN....YKDLQNRDTDYFRfhD
 1411- 1433 (22.98/14.13)	LKLVHavnsDVALENKNSGYLG..D
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.56|      27|     287|    1243|    1272|       5
---------------------------------------------------------------------------
 1243- 1272 (43.70/33.72)	NDLLylkANPISSKEDTFKLMKIISEFNLP
 1543- 1569 (49.85/29.92)	NDHL...NQPPYSKPSASGLPLVSSMFNLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.93|      14|     366|    1021|    1039|       7
---------------------------------------------------------------------------
 1021- 1034 (23.17/ 6.54)	SMNVDVNAFKDLKR
 1374- 1386 (23.14/ 6.52)	SMNL.LPVFKDYFK
 1395- 1408 (22.62/ 8.89)	DIPSSYKFFQDLSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.08|      33|      86|     493|     527|       8
---------------------------------------------------------------------------
  495-  527 (58.61/32.91)	LINYRN..........ESLMLNMRHLSQTSNSIEMAPPSSNNR
  573-  615 (53.47/31.72)	FINRRNydslkiieqfDRLQLNDELASYLRPKPDNWPNSNTWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.54|      39|     492|     779|     859|       9
---------------------------------------------------------------------------
  779-  827 (53.15/81.86)	QVLQEQIINKLLNNSFddnieqnmdYIKELnVGLKFMLVNWITTNLKNS
  867-  905 (65.39/22.13)	LRNEGKIIIFYLDSLY.........FISKL.IIRHFKLVKFIAGNNYES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.30|      42|     296|     642|     698|      10
---------------------------------------------------------------------------
  644-  694 (67.28/59.49)	NFLKRNVlqklsgkntNNWKAEFEN.............EIMEIIYEVVDKHDEEVNYYY........LYVLI
  938- 1000 (56.02/29.47)	NFINRAV.........ENSEATFNNgtsisknnplyakEMVDSPMKIHMQENNKVNEKYsaedfrndLEVLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.60|      20|     157|    1299|    1318|      11
---------------------------------------------------------------------------
 1299- 1318 (36.47/20.75)	EQ..FVEMVLDNLNFQFLSYNS
 1459- 1480 (29.13/15.04)	EQftFIKNLISLLNSRFLSTKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.39|      17|    1017|     164|     180|      12
---------------------------------------------------------------------------
  164-  180 (29.70/15.76)	NSFKIPPRVTLTTLKKE
 1216- 1232 (29.68/15.74)	NSFFLHTKLTIDTLTKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     152.49|      38|     461|     718|     755|      15
---------------------------------------------------------------------------
  718-  755 (67.93/46.85)	FY.ITPGTNTDLPEGSKYNRQVDIHLSILRNLPVLNNKQ
 1146- 1170 (31.46/17.17)	FF....ETQTSLERQYLLNHQI.LFLEVLR.........
 1172- 1208 (53.10/34.78)	FYnIKDGT.SELLIASKALKE.DQKESIYQSYILENYKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.40|      24|     411|      12|      35|      23
---------------------------------------------------------------------------
   12-   35 (42.49/26.04)	SSH...NRTSFSNSTKEEIL.....SMKYLME
  419-  450 (29.91/16.03)	SSHktnEKTALPSNLKQKILlhisdSVEYLFK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10198 with Med12 domain of Kingdom Fungi
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