<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10196

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceKSPPPIPHISNNIIPLSNILKFYTQEAYKQLLTIIENLSSTVESESDSNRKKKFLTAIISLRQDFIKIYTLVKWAQNSKDVSKLIDLLNFLRSQDFYFEQLGFGLNELNRYLGAQLPNSDLLSSLEILIKGRPQLPSYNLIKPLKISTEKTLEVLQDLNLILTTRMALIDDLPKRFMNNYTIKDGRVIFTIPNEFEVAITVANDLIIDKIEDYYQSPFFFISFKFLFGINPDTSLITHKDNKIATKLPQKSHENLERIINQVLLKQGLNGLYDTLHKYSISFKLYLIARQLKELSTNSKWKNSIQFKYQSSLIIINYWSSHYLSRNWKSFIELGIDKNYNLNFRWFKNGRYSTAHLNKDSEKDSTGILSESIPGFNSNDDEEDLSVDLILNIIINKHSESSISNIYSKLLELLPEDSCSILSPHQLLLNLTPTKKTIFAINPLTGFFYFMDPSPIQNYITKRINSQPSIIKNKNFITEDDMMNNVVSNLIQLKLETLNKEINNKLITTEWISNNIIHLNDLETLKLFEFDINEKEQSNNKIQFYRCKNWPSSWFLINLIAGLTSKTYWWVARIKSIKGEWKIQWVEKLKVNDDLSYEFFDDLSITCSNKIIDHMITEELQIRSSRFLKVEKNAIDVFKLPLDKNIDTNTIYESIIMIHNHGEFLPLSNSSNSLFLLVKLTNTNNVTQMNLRLMGHIKNLPLNDNSNDDFSKLSLLFKKDMFEIVDLIDLTSRMNDSEHDNSNNKLLLDNLFNNLNKLNQLIKLLEQLNKTNIEIIQNQINEISIKINPIYSTFKLVLPEQENGSITILTDKDELNEVKIMVKFLNQNSIEKKNTMIGSIKYLQELVPILKALRAIQTHLIINNSMKLSNGLQKLQFDTRLENLNTIQFVYTINSINPSNPKKVAKDRISLCLNFKMNKFAKKEKLLIRLSMKDNLNSRNLKFKKLFESIFKSINEFDASLSSVNNTNGSTNGSANGKTSTTTLMKFNYDYLLDSILLEDMMMRIADCFLNY
Length1011
PositionTail
OrganismHyphopichia burtonii NRRL Y-1933
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Hyphopichia.
Aromaticity0.09
Grand average of hydropathy-0.283
Instability index34.57
Isoelectric point8.73
Molecular weight117291.81
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10196
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     201.07|      39|     114|     750|     788|       1
---------------------------------------------------------------------------
  455-  485 (33.33/14.42)	IQNYITKrINS..............QPSIIknKNFITEDDMMNNV
  486-  510 (31.73/13.34)	VSN........LIQLkL..ETLNK..........EINNKLITTEW
  750-  788 (63.34/34.69)	LFNNLNK.LNQLIKL.L..EQLNKTNIEII..QNQINEISIKINP
  791-  823 (21.08/ 6.15)	..........STFKL.VlpEQEN.GSITILtdKDELNEVKIMVKF
  867-  900 (51.59/26.75)	LSNGLQK.L.QFDTR.L..ENLN..TIQFV..YT.INSINPS.NP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.20|      34|      34|     646|     679|       2
---------------------------------------------------------------------------
  646-  679 (58.40/29.20)	DTNTIYESIIMIH.....NHGEFLPLSNSSNSLFLLVKL
  681-  714 (53.90/26.40)	NTNNVTQMNLRLM.....GHIKNLPLNDNSNDDFSKLSL
  719-  747 (25.90/ 8.97)	D...MFEIVDLIDltsrmNDSEH...DNSNNKLLL....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.98|      43|     269|     102|     178|       3
---------------------------------------------------------------------------
  129-  176 (59.81/66.04)	IKGRPQLpsyNLIKPLKISTEKTLEVLQDLNLILTTRmaLIDDL........PKRF
  576-  626 (69.17/25.35)	IKGEWKI...QWVEKLKVNDDLSYEFFDDLSITCSNK..IIDHMiteelqirSSRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.79|      21|      76|     313|     333|       6
---------------------------------------------------------------------------
  313-  333 (40.17/24.46)	IIINYWSSHYLSRNWKSFIEL
  392-  412 (34.62/19.97)	IIINKHSESSISNIYSKLLEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.75|      10|      22|     912|     921|      10
---------------------------------------------------------------------------
  912-  921 (18.37/ 9.74)	LNFKMNKFAK
  935-  944 (17.38/ 8.79)	LNSRNLKFKK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10196 with Med14 domain of Kingdom Fungi
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