<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10194

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTEVSLKKLIGLSVKRKTSSKVFVSLFNQLNERSPVTEDEFLDTFLNYPGNEEEAAKAIEYCIKTSLSSETNMARLWNLMSKLEVKQQVKILKEVNKILLKEGKLSTKLQACMIESIIKYSGSVMSEGTLVYQSVLLLGSIVKKWHLIDGETKVILSNFIDTLDASSYKDLSRFLIKSSGQSLGKFHAVKPSEASHNIVNTNQLSKDITMINSNSSKFNELNNLKSYLWLYDLMENWSFSKNQIFVNSYEKLFCSSSKSKNKHTSIVNMVESIFNGFVTSLTNQAPSYIIYNWKNFLITKLPDILLKVASPKSIIQDAIKDCFKAFDDVTNKTLSTFNWNNSIFDIRRIFIKHCIYAEVLPLEFYFEQFPEDGDKFNSTILNNEKNFTIKSIEDELTIKLLEINSEFTSLVESGLIEYINQLPDQIRFQPKYQQELTVIINKVIDSLIEEKNIEKLNRLIIAITNNYEVLNLIFINDNQGPWNVLNKLIQFIDSENFNIEEDDNFQESYSYFGVLILGIITIIETFNIDISNTSIMNSYTIDYINNFYYRHCDNLTSQVNTTEEEELTIISNYNNLINEWINSLFDDNNDGLSDELIKSINVKQIYKIIPIIYKQAIIATENGKINEDILNGGIDYLSQIFLVPCTLSVIKWLLNKIEIESFKSTFDTKSHLWIKILFEILKSNLGDSINDGEFQFSNDESNLIFKIVLKISGSSIIEILTRFPLWNNVELIKKIINIVQKTIDPNYKKQSFKITTNLNFIDELKLNLNNHNLVNQLISKIDKNELVRYLITEFNNYQHNINNEDSKISINLLTFIILLKSFKSFDSKALLIKLFNQCRNELPNSSKIDLSFNITIDFNFSVIFNDPNLENSEDDDLFNESPSKFQVKDHYNKITQLNTGLYQFVKIYQIFKNNLDSVFQKTLAVLKNKFINEYDLFL
Length938
PositionTail
OrganismHyphopichia burtonii NRRL Y-1933
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Hyphopichia.
Aromaticity0.11
Grand average of hydropathy-0.169
Instability index39.38
Isoelectric point5.30
Molecular weight108605.97
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10194
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     492.90|      81|      91|     516|     596|       1
---------------------------------------------------------------------------
  398-  461 (68.74/29.45)	IKLLEINSEFTSLVESGL.IEYIN...............................QLPDQIrfQPK..................YQQELTVI.........INKVIDSLIEEKNIEKL..NRL..............II................
  462-  522 (37.31/12.38)	...........AITNNY...................................................................EVLNLIFINDNQgpwNVLNKLI.QFIDSENFNIEedDNF....qesysyfgvlILGI........I...TI
  523-  617 (121.74/58.24)	IETFNIDISNTSIMNSYT.IDYINN....F.................YYRHC..DNLTSQV..NTT..................EEEELTIISNYN...NLINEWINSLFDDNNDGLS..DEL...iksinvkqiykIIPI........IykqAI
  618-  708 (78.21/34.60)	IATENGKI.NEDILNG.G.IDYLSQ....I.................FLVPCtlSVIKWLL..NKI..................EIE..SFKSTFD...TKSHLWIKILFEILKSNLG..DSIndgefqfsndesnlIFKI........V.....
  709-  793 (68.49/29.32)	.....LKISGSSIIEILTrFPLWNN....VelikkiinivqktidpnYKKQS..FKITTNL..NFI..................DELKLNL..NNH...NLVNQLISKI..DKN.......EL..............VRYL........I...TE
  794-  856 (66.36/28.16)	FNNYQHNINNED..SKIS.INLL.T....F.................II.......LLKSF..KSF..................DSKAL.LIKLFN...QCRNELPNS.................................skidlsfnI...TI
  857-  937 (52.05/20.39)	DFNFSVIFNDPNLENSED.DDLFNEspskF.................QVKDH..YNKITQL..NTGlyqfvkiyqifknnldsvFQKTLAVLK..N...KFINEY..DLF.............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.60|      25|      44|      80|     104|       2
---------------------------------------------------------------------------
   80-  104 (39.99/29.59)	MSK.LEVKQQVKILKE.VNKILLKEGK
  125-  151 (34.61/24.54)	MSEgTLVYQSVLLLGSiVKKWHLIDGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     164.08|      33|      89|     271|     303|       3
---------------------------------------------------------------------------
  271-  303 (57.95/32.51)	ESIFNGFVTSLTNQAPSYIIYNWKNFLITKLPD
  320-  348 (50.93/27.63)	KDCFKAF.DDVTNKTLS..TFNWNNS.IFDIRR
  363-  394 (55.20/30.60)	EFYFEQFPED.GDKFNSTILNNEKNFTIKSIED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.43|      15|      34|     204|     218|       7
---------------------------------------------------------------------------
  204-  218 (25.18/12.87)	LSKDITMINSNSSKF
  239-  253 (26.24/13.73)	FSKNQIFVNSYEKLF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10194 with Med5 domain of Kingdom Fungi
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