<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10193

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMSEDLISSLYPPPPPYFKFFTQENLNKVNSWKKEQDQEESSPEDPRKVPEGELQFLIPPEQPSGTHYRGYGNLWSFEDKLPSLKEAGWTQLYKEEDELITSQTKIKELHKLMDSLLLNFLELIGSMSVDPSKFHYKIEDLKLLLININHILNTYRPHQTRESLIMLLKKQIDKKNNEINEIDKVSTSITEKIQKLTNNVKGTNEDVDESNESSSAELKKKLLDKLLYQST
Length230
PositionMiddle
OrganismHyphopichia burtonii NRRL Y-1933
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Hyphopichia.
Aromaticity0.08
Grand average of hydropathy-0.793
Instability index52.04
Isoelectric point5.29
Molecular weight26755.01
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. 


GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10193
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     170.30|      42|     109|      75|     116|       1
---------------------------------------------------------------------------
   75-  116 (68.40/32.68)	SFEDKLPSLKEA..GWTQLYKEED..ELITSQTKIKEL...HKLMDSLL
  118-  164 (53.14/24.20)	NFLELIGSMSVD..PSKFHYKIEDlkLLLININHILNTyrpHQTRESLI
  187-  226 (48.76/21.77)	SITEKIQKLTNNvkGTNEDVDESN..E..SSSAELKK.....KLLDKLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10193 with Med7 domain of Kingdom Fungi
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