Description | Mediator of RNA polymerase II transcription subunit 7 |
Sequence | MSEDLISSLYPPPPPYFKFFTQENLNKVNSWKKEQDQEESSPEDPRKVPEGELQFLIPPEQPSGTHYRGYGNLWSFEDKLPSLKEAGWTQLYKEEDELITSQTKIKELHKLMDSLLLNFLELIGSMSVDPSKFHYKIEDLKLLLININHILNTYRPHQTRESLIMLLKKQIDKKNNEINEIDKVSTSITEKIQKLTNNVKGTNEDVDESNESSSAELKKKLLDKLLYQST |
Length | 230 |
Position | Middle |
Organism | Hyphopichia burtonii NRRL Y-1933 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Hyphopichia. |
Aromaticity | 0.08 |
Grand average of hydropathy | -0.793 |
Instability index | 52.04 |
Isoelectric point | 5.29 |
Molecular weight | 26755.01 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery.
ECO:0000256 RuleBase:RU364060 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP10193 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 170.30| 42| 109| 75| 116| 1 --------------------------------------------------------------------------- 75- 116 (68.40/32.68) SFEDKLPSLKEA..GWTQLYKEED..ELITSQTKIKEL...HKLMDSLL 118- 164 (53.14/24.20) NFLELIGSMSVD..PSKFHYKIEDlkLLLININHILNTyrpHQTRESLI 187- 226 (48.76/21.77) SITEKIQKLTNNvkGTNEDVDESN..E..SSSAELKK.....KLLDKLL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ELKKKLLDKLLYQST 2) MSEDLISSLY 3) PPYFKFFTQENLNKVNSWKKE | 216 1 14 | 230 10 34 |
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