<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10191

Description Mediator of RNA polymerase II transcription subunit 18
SequenceMVHQLSLVSSIPHSSYIQTVSTLQALTGLTSPQPINTYTLLTRPHDVFKPKFEPGKVNQIEQYHMRCTTTWSDVTSENLDISKPIMKNDESNEIYADRLFVGDDTKKEWTLQISDIPNAGKNQVCSAQNIYESTLVHHHTSVVDIEKVSVEDKQDDAMEIDEPVKEEPKSQTMSEDSPLKKEADDKPEPNEGKLDESKPEEGKADESKPDESKADENKSDESKSESNLDKSKPDEIKPESKPESKPESNTESKPDESKEIKSENPSEPIEVSDQPKFKEVEVKKYQDSFLQFLGDLGYDVVNQYWIKGIRFFHGDIVIEIFKIFIRDDSPVPSNGKLKLKLLDESNTFQIKAYLNFPKSTDVEPIKQECIWTQES
Length375
PositionHead
OrganismHyphopichia burtonii NRRL Y-1933
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Hyphopichia.
Aromaticity0.07
Grand average of hydropathy-0.937
Instability index41.80
Isoelectric point4.72
Molecular weight42671.84
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364150

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10191
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.35|      18|      19|     210|     227|       1
---------------------------------------------------------------------------
  206-  224 (27.06/11.24)	ESK....pDESKADENKSD...ESKS
  225-  246 (24.77/ 9.72)	ESN....lDKSKPDEIKPEskpESKP
  247-  266 (21.51/ 7.54)	ESNteskpDESK..EIKS....ENPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     126.72|      26|      31|     146|     171|       2
---------------------------------------------------------------------------
   73-   92 (21.06/ 7.78)	......D..VTSENLD.....ISKPIMKNDESN
   97-  123 (33.82/16.89)	DRLFVGDdtKKEWTLQ.....ISD.IPNAGKNQ
  146-  171 (40.72/21.81)	EKVSVED..KQDDAME.....IDEPVKEEPKSQ
  175-  205 (31.12/14.96)	EDSPLKK..EADDKPEpnegkLDESKPEEGKAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.16|      15|      18|     282|     296|       4
---------------------------------------------------------------------------
  282-  296 (26.41/17.48)	VKKYQDSFLQFL.GDL
  301-  316 (24.74/15.99)	VNQYWIKGIRFFhGDI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10191 with Med18 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LVHHHTSVVDIEKVSVEDKQDDAMEIDEPVKEEPKSQTMSEDSPLKKEADDKPEPNEGKLDESKPEEGKADESKPDESKADENKSDESKSESNLDKSKPDEIKPESKPESKPESNTESKPDESKEIKSENPSEPIEVSDQPKF
135
277










Molecular Recognition Features






MoRF SequenceStartStop




1) IYADRL
94
99