<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10182

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLTESLNASRILTNFYKLGHLSNVSYTVYGQKASTELNDQSLLELELSIRYDHPRVLVTYYNKCLYQFVLTYENDTADSNGDQEWKNEDDQQNEQNQEPVQQSQQHNTNYTPPWDLSKEYPRLEVKFCNNVPVDYLSNPNSKSIDRKDEYLAYASLSFLKAIKKLVLYNLSLNNVAHLFGNHAVVNQNLSNSIIHIDPILLPNGDLLLSISTKRNLSLFNSSIVDHNDPMALDSNFIIYLIPSGIRCHLYDNVNKKQSFTYNPPKNCENLIKLIRLSTGVDLSNEKFLWVKLIPNLQHLNNQTSNISKFVHLVDNKKFILWPWKLCLLQFGYIEKQVYDNQNHLSQNQPFRSSSSDIDPLGLISDFMDFSISTHQSKSSSNNFTAPSASALSTGPNSTGPTNNETGSTVKNEDHLDMTNSMMNDIFDISMAPNESMNFFQNETKDTHQDQKGNHLNEGDQMIEENQEEQENQAKEEDQLDDLFGDDSSDEDQSQAAKPVEPQFDNNFDLQPSSQPIEVDEENKPIQADKDSTKELDLFYETQQDESKKDPEKDVEKEFKEPKPRSSTSASNSTYIDIPKDQMTIAPLRYLKTQTPQVYDDPGAPLPIVPTPIIPSSAPQSSGTIPDQKNSFNDLKNLNFYNNHLGHIGSSWTPSGAPEIDNKSVFSPLLFNPIIKSNIDTKYGKGGKFYVDKELSAGSDSESKKRKLRATSVSGYEYPAKKEDRGHSFDILNERGLGIIRSENQDRGIVSNEDNENAIADDDDPSDQSDDDEEEDDDDEESDEDEDINQNKVADHSKEQNSPPLKLNTDNDQGSSNQGNNLDTTQKQLNPSTLTNTGGFFSPLGQAAKYNTGSKFDSPLGMNSSFVDNNQMVTGSPSSIFDNKHLQPPPSAPVFQDDFQGHESFSPDDDSKKDQSPVSTGNTPAVSSPSKTVGISESSNCLPLILRGINVVSIPSLFLLNNISGSMNISTVTSDFNMDVDEEENDFEINQNNELVVKVNHLDEFLKWLGLNLVFDLGLNKYESNLRLSLPSNASKLTENDTFSSVDIGVPISQFESKFFKLFPLCYKVSLNEFINEISPQDPQDSTVQDELTNQLSFLDDIANDDILNPKSQLKKLNSIKWDSFYTVNQRNEENYRHYKEIIESFNKVNSYIKNDEDHLFQLLDNKARVLKNNDEIINLNSVGLRFWGYLNYSPLNGPKNFQVLLISERGQEENNCNSEFLNSLIYNYNEGHFGNITKLNLQSLDSKQDFESINDGLLLMNKGEDSVTSSYTDVYKKINKRLTSLVELIKLDLINKTNSFEFDRPLLLFFVDFDDNVNSMLQISKICRNFKLFLNQYQLPLVEIFTHVIPASFIFKQVANQKSVRYLSNYKLSRISMTLYNKCPDPFLGLKSLTNKQLTKSLFTNLVKSPPSKLQFKFLSNGGKESTSLAYNDDIFLHLAYERTVDKNWVSAAWSDPFGVTTHVKSWYCSPTNNKKHTKDIYEMGEVIDEIWNISNELFKTLNAEIIKKTSGLGGKKFLVLTRINNVIPDDELVHWKRLSMKYKDVSLIVLSVNRTPRVLFNVDFTSNRDVSPDDNDLVQDDASNASSNNNVGLSTAAATIAGSSNSTTGLNSSGNTVAGQAQPSSASGLLTGLNQQQQGQQNPSSNIVSGGQKNAAPTGMGSATTPSAPGSAPDFFKNFNNFPPSSNSSPTTTGATMITSPSHNGGINFHSPQQFLNAPGNFLSPQDLVGTGASGTANNVTTNGHSTVGAGVNSANGPGIIFNESDVVLHDRNSDITAVIPRTALPSFTSPSKLGMKIGYLLKECGNDSEEVGDGGSVKKYLVYETTILSCSNFWKLDAIMKIMLEQYKKLISLNDILGLTEIQTSTSSTKVDVTTDNFDQQEVDHKDAVLLVPWHINAVGKSLDYLIHVSVEE
Length1915
PositionKinase
OrganismHyphopichia burtonii NRRL Y-1933
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Hyphopichia.
Aromaticity0.08
Grand average of hydropathy-0.604
Instability index39.18
Isoelectric point4.80
Molecular weight213946.38
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10182
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.53|      15|      15|    1589|    1603|       1
---------------------------------------------------------------------------
 1589- 1603 (24.72/16.00)	NNNVGLSTAAATIAG
 1606- 1620 (25.81/17.11)	NSTTGLNSSGNTVAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.32|      29|      30|     476|     504|       2
---------------------------------------------------------------------------
  476-  504 (48.20/22.16)	EDQLDDLFGDDSSDEDQS.QAAKPVEPQFD
  531-  558 (34.20/13.57)	STKELDLFYETQQDESKK.DPEKDVEKEF.
  775-  794 (25.91/ 8.49)	DDD......DEESDEDEDiNQNK.VA...D
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     298.69|      93|     159|     115|     220|       3
---------------------------------------------------------------------------
  115-  220 (137.21/105.52)	DLSKEyPRLEVKFCNNvpVDYLSNPNSkSIDrkdeylayaSLSFLKAIKKLVLYNLSLNNVAHLF........GNHAVVNQNLSNSIIHIDPILLPNGDLLLSISTKRNLSLFN
  281-  381 (161.48/91.87)	DLSNE.KFLWVKLIPN..LQHLNNQTS.NIS.........KFVHLVDNKKFILWPWKLCLLQFGYiekqvydnQNHLSQNQPFRSSSSDIDPLGLISDFMDFSISTHQSKSSSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.76|      16|      16|    1657|    1672|       4
---------------------------------------------------------------------------
 1657- 1672 (27.61/11.52)	APTGMGS.A..TTPSAPGS
 1673- 1689 (21.66/ 7.27)	APDFFKNfN..NFPPSSNS
 1690- 1707 (21.49/ 7.15)	SPTTTGA.TmiTSPSHNGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     153.05|      52|     159|     839|     898|       5
---------------------------------------------------------------------------
  389-  430 (45.70/19.72)	.................SALSTGpnSTGPTNNE..TG..STVKNEDHLDMTNSmmNDIFDISM
  439-  466 (29.33/10.30)	FQ...NETKDTHQDQKGNHLNEG..DQMIEENQ..............................
  840-  898 (78.01/65.43)	FSplgQAAKYNTGSKFDSPLGMN..SSFVDNNQmvTGspSSIFDNKHLQPPPS..APVFQDDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.86|      13|      16|    1621|    1633|       6
---------------------------------------------------------------------------
 1621- 1633 (21.72/12.12)	QAQPSSASGLLTG
 1639- 1651 (23.14/13.50)	QGQQNPSSNIVSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.74|      35|      38|    1168|    1204|       7
---------------------------------------------------------------------------
 1140- 1163 (26.37/ 8.99)	.......EIIeSFNKVN.......SYIK...NDEDH.LFQLL
 1168- 1204 (56.11/35.35)	RVLKNNdEII.NLNSVGLRFWGYlNYSP...LNGPK.NFQVL
 1209- 1244 (46.26/21.58)	RGQEEN.....NCNSEFLNSLIY.NYNEghfGNITKlNLQSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.75|      15|      16|     742|     756|       8
---------------------------------------------------------------------------
   95-  109 (25.22/10.81)	QNQEPVQQSQQHNTN
  742-  756 (25.41/10.95)	ENQDRGIVSNEDNEN
  760-  774 (24.12/10.00)	DDDDPSDQSDDDEEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.18|      11|      15|    1094|    1104|       9
---------------------------------------------------------------------------
 1094- 1104 (19.08/10.54)	QLSFLDDIAND
 1112- 1122 (20.10/11.53)	QLKKLNSIKWD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.91|      29|      49|     561|     590|      11
---------------------------------------------------------------------------
  561-  590 (47.12/24.07)	PKPRSSTSASNSTYiDIPKDQMTIAPLRYL
  609-  637 (51.78/23.28)	PTPIIPSSAPQSSG.TIPDQKNSFNDLKNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.38|      12|      16|     651|     662|      13
---------------------------------------------------------------------------
  651-  662 (23.36/16.80)	WTPSGAPEIDNK
  670-  681 (21.02/14.12)	FNPIIKSNIDTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.93|      15|      16|     941|     955|      14
---------------------------------------------------------------------------
  941-  955 (24.51/17.31)	LPLILRGINVVSIPS
  959-  973 (24.42/17.21)	LNNISGSMNISTVTS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10182 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APLRYLKTQTPQVYDDPGAPLPIVPTPIIPSSAPQSSGTIPDQKN
2) GSSNSTTGLNSSGNTVAGQAQPSSASGLLTGLNQQQQGQQNPSSNIVSGGQKNAAPTGMGSATTPSAPGSAPDFFKNFNNFPPSSNSSPTTTGATMITSPSHNGGINFHSPQQFLNAPGNFLSPQDLVGTGASGTANNVTTNGHSTVGA
3) IRSENQDRGIVSNEDNENAIADDDDPSDQSDDDEEEDDDDEESDEDEDINQNKVADHSKEQNSPPLKLNTDNDQGSSNQGNNLDTTQKQLNPSTLTNTGGFFSPLGQAAKYNTGSKFDSPLGMNSSFVDNNQMVTGSPSSIFDNKHLQPPPSAPVFQDDFQGHESFSPDDDSKKDQSPVSTGNTPAVSSPSKT
4) KSSSNNFTAPSASALSTGPNSTGPTNNETGSTVKNEDHLDMTNSMMNDIFDISMAPNESMNFFQNETKDTHQDQKGNHLNEGDQMIEENQEEQENQAKEEDQLDDLFGDDSSDEDQSQAAKPVEPQFDNNFDLQPSSQPIEVDEENKPIQADKDSTKELDLFYETQQDESKKDPEKDVEKEFKEPKPRSSTSASNSTYIDIP
5) SNGDQEWKNEDDQQNEQNQEPVQQSQQHNTNYTPP
6) VSPDDNDLVQDDASNASSNNNVGLSTAAATI
7) YVDKELSAGSDSESKKRKLRATSVSGYEYPAKKEDRGHSFDILNERGLG
585
1603
739
377
79
1571
689
629
1751
931
578
113
1601
737










Molecular Recognition Features






MoRF SequenceStartStop




1) ELDLFYE
2) IAPLRY
3) KFYVDKEL
4) TYIDIPK
534
584
687
573
540
589
694
579