<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10182

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLTESLNASRILTNFYKLGHLSNVSYTVYGQKASTELNDQSLLELELSIRYDHPRVLVTYYNKCLYQFVLTYENDTADSNGDQEWKNEDDQQNEQNQEPVQQSQQHNTNYTPPWDLSKEYPRLEVKFCNNVPVDYLSNPNSKSIDRKDEYLAYASLSFLKAIKKLVLYNLSLNNVAHLFGNHAVVNQNLSNSIIHIDPILLPNGDLLLSISTKRNLSLFNSSIVDHNDPMALDSNFIIYLIPSGIRCHLYDNVNKKQSFTYNPPKNCENLIKLIRLSTGVDLSNEKFLWVKLIPNLQHLNNQTSNISKFVHLVDNKKFILWPWKLCLLQFGYIEKQVYDNQNHLSQNQPFRSSSSDIDPLGLISDFMDFSISTHQSKSSSNNFTAPSASALSTGPNSTGPTNNETGSTVKNEDHLDMTNSMMNDIFDISMAPNESMNFFQNETKDTHQDQKGNHLNEGDQMIEENQEEQENQAKEEDQLDDLFGDDSSDEDQSQAAKPVEPQFDNNFDLQPSSQPIEVDEENKPIQADKDSTKELDLFYETQQDESKKDPEKDVEKEFKEPKPRSSTSASNSTYIDIPKDQMTIAPLRYLKTQTPQVYDDPGAPLPIVPTPIIPSSAPQSSGTIPDQKNSFNDLKNLNFYNNHLGHIGSSWTPSGAPEIDNKSVFSPLLFNPIIKSNIDTKYGKGGKFYVDKELSAGSDSESKKRKLRATSVSGYEYPAKKEDRGHSFDILNERGLGIIRSENQDRGIVSNEDNENAIADDDDPSDQSDDDEEEDDDDEESDEDEDINQNKVADHSKEQNSPPLKLNTDNDQGSSNQGNNLDTTQKQLNPSTLTNTGGFFSPLGQAAKYNTGSKFDSPLGMNSSFVDNNQMVTGSPSSIFDNKHLQPPPSAPVFQDDFQGHESFSPDDDSKKDQSPVSTGNTPAVSSPSKTVGISESSNCLPLILRGINVVSIPSLFLLNNISGSMNISTVTSDFNMDVDEEENDFEINQNNELVVKVNHLDEFLKWLGLNLVFDLGLNKYESNLRLSLPSNASKLTENDTFSSVDIGVPISQFESKFFKLFPLCYKVSLNEFINEISPQDPQDSTVQDELTNQLSFLDDIANDDILNPKSQLKKLNSIKWDSFYTVNQRNEENYRHYKEIIESFNKVNSYIKNDEDHLFQLLDNKARVLKNNDEIINLNSVGLRFWGYLNYSPLNGPKNFQVLLISERGQEENNCNSEFLNSLIYNYNEGHFGNITKLNLQSLDSKQDFESINDGLLLMNKGEDSVTSSYTDVYKKINKRLTSLVELIKLDLINKTNSFEFDRPLLLFFVDFDDNVNSMLQISKICRNFKLFLNQYQLPLVEIFTHVIPASFIFKQVANQKSVRYLSNYKLSRISMTLYNKCPDPFLGLKSLTNKQLTKSLFTNLVKSPPSKLQFKFLSNGGKESTSLAYNDDIFLHLAYERTVDKNWVSAAWSDPFGVTTHVKSWYCSPTNNKKHTKDIYEMGEVIDEIWNISNELFKTLNAEIIKKTSGLGGKKFLVLTRINNVIPDDELVHWKRLSMKYKDVSLIVLSVNRTPRVLFNVDFTSNRDVSPDDNDLVQDDASNASSNNNVGLSTAAATIAGSSNSTTGLNSSGNTVAGQAQPSSASGLLTGLNQQQQGQQNPSSNIVSGGQKNAAPTGMGSATTPSAPGSAPDFFKNFNNFPPSSNSSPTTTGATMITSPSHNGGINFHSPQQFLNAPGNFLSPQDLVGTGASGTANNVTTNGHSTVGAGVNSANGPGIIFNESDVVLHDRNSDITAVIPRTALPSFTSPSKLGMKIGYLLKECGNDSEEVGDGGSVKKYLVYETTILSCSNFWKLDAIMKIMLEQYKKLISLNDILGLTEIQTSTSSTKVDVTTDNFDQQEVDHKDAVLLVPWHINAVGKSLDYLIHVSVEE
Length1915
PositionKinase
OrganismHyphopichia burtonii NRRL Y-1933
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Hyphopichia.
Aromaticity0.08
Grand average of hydropathy-0.604
Instability index39.18
Isoelectric point4.80
Molecular weight213946.38
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10182
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.53|      15|      15|    1589|    1603|       1
---------------------------------------------------------------------------
 1589- 1603 (24.72/16.00)	NNNVGLSTAAATIAG
 1606- 1620 (25.81/17.11)	NSTTGLNSSGNTVAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.32|      29|      30|     476|     504|       2
---------------------------------------------------------------------------
  476-  504 (48.20/22.16)	EDQLDDLFGDDSSDEDQS.QAAKPVEPQFD
  531-  558 (34.20/13.57)	STKELDLFYETQQDESKK.DPEKDVEKEF.
  775-  794 (25.91/ 8.49)	DDD......DEESDEDEDiNQNK.VA...D
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     298.69|      93|     159|     115|     220|       3
---------------------------------------------------------------------------
  115-  220 (137.21/105.52)	DLSKEyPRLEVKFCNNvpVDYLSNPNSkSIDrkdeylayaSLSFLKAIKKLVLYNLSLNNVAHLF........GNHAVVNQNLSNSIIHIDPILLPNGDLLLSISTKRNLSLFN
  281-  381 (161.48/91.87)	DLSNE.KFLWVKLIPN..LQHLNNQTS.NIS.........KFVHLVDNKKFILWPWKLCLLQFGYiekqvydnQNHLSQNQPFRSSSSDIDPLGLISDFMDFSISTHQSKSSSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.76|      16|      16|    1657|    1672|       4
---------------------------------------------------------------------------
 1657- 1672 (27.61/11.52)	APTGMGS.A..TTPSAPGS
 1673- 1689 (21.66/ 7.27)	APDFFKNfN..NFPPSSNS
 1690- 1707 (21.49/ 7.15)	SPTTTGA.TmiTSPSHNGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     153.05|      52|     159|     839|     898|       5
---------------------------------------------------------------------------
  389-  430 (45.70/19.72)	.................SALSTGpnSTGPTNNE..TG..STVKNEDHLDMTNSmmNDIFDISM
  439-  466 (29.33/10.30)	FQ...NETKDTHQDQKGNHLNEG..DQMIEENQ..............................
  840-  898 (78.01/65.43)	FSplgQAAKYNTGSKFDSPLGMN..SSFVDNNQmvTGspSSIFDNKHLQPPPS..APVFQDDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.86|      13|      16|    1621|    1633|       6
---------------------------------------------------------------------------
 1621- 1633 (21.72/12.12)	QAQPSSASGLLTG
 1639- 1651 (23.14/13.50)	QGQQNPSSNIVSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.74|      35|      38|    1168|    1204|       7
---------------------------------------------------------------------------
 1140- 1163 (26.37/ 8.99)	.......EIIeSFNKVN.......SYIK...NDEDH.LFQLL
 1168- 1204 (56.11/35.35)	RVLKNNdEII.NLNSVGLRFWGYlNYSP...LNGPK.NFQVL
 1209- 1244 (46.26/21.58)	RGQEEN.....NCNSEFLNSLIY.NYNEghfGNITKlNLQSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.75|      15|      16|     742|     756|       8
---------------------------------------------------------------------------
   95-  109 (25.22/10.81)	QNQEPVQQSQQHNTN
  742-  756 (25.41/10.95)	ENQDRGIVSNEDNEN
  760-  774 (24.12/10.00)	DDDDPSDQSDDDEEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.18|      11|      15|    1094|    1104|       9
---------------------------------------------------------------------------
 1094- 1104 (19.08/10.54)	QLSFLDDIAND
 1112- 1122 (20.10/11.53)	QLKKLNSIKWD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.91|      29|      49|     561|     590|      11
---------------------------------------------------------------------------
  561-  590 (47.12/24.07)	PKPRSSTSASNSTYiDIPKDQMTIAPLRYL
  609-  637 (51.78/23.28)	PTPIIPSSAPQSSG.TIPDQKNSFNDLKNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.38|      12|      16|     651|     662|      13
---------------------------------------------------------------------------
  651-  662 (23.36/16.80)	WTPSGAPEIDNK
  670-  681 (21.02/14.12)	FNPIIKSNIDTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.93|      15|      16|     941|     955|      14
---------------------------------------------------------------------------
  941-  955 (24.51/17.31)	LPLILRGINVVSIPS
  959-  973 (24.42/17.21)	LNNISGSMNISTVTS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10182 with Med13 domain of Kingdom Fungi
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