<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10172

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSTNYAKLARLAQVNYSIYTSAKADDQSVLEAELLLRSHTPNVLATYYAKELWVYSLNDTPLPAIPASYHLKFQSSGTIPPLKFFQKLAPPAELPNFQFIHLTFIKSVKKLVLTRLTLEKAVAPFGNHCVSLLPADRRCVVLIDPILTPQGDLYLNICSKEHHLRTFKELPSDSSDPEDVSERAYAIYLIPSGIRAHFADETLQESRAAPPANYAQLVQTLRLALALPLPLDPAQLTWVRLVPNLNHLNNLTPAICQFLQNGFANTKLVIWPLELCYVQGAVATAAMEMAEFSDPLRWVDDFSNWQQHTNTIRLEHLKFQSAVNTPMSTMATPMDAAALAMTLVPAPSTEEDWGNLSEELFGDDGMDEKVTEGDFNFFDEYPSGEAARDDTASEPRPEDVNDARTDAVTDTEPDAANDTHEDVVNNARVDANGEACADAVSAATNTARSVLSPVPLSPAPPSPALLDIPMDKMIQPPKTPGCYRDPGAPLPIESPNPPMRRQSAFSPLTFNPIIKSGVDAKYVNGGRFYVPEKMGLVTAISSDETGSDSDADSHSDGPETHAHTSTPSKRAREPEPNNNDDLVRGSPSAFAEPFDLKPTLGVSSTAALPNIDEKPVKRARGEGSLASTNWLPLLLRSINVFLIPDVFYTENPTIRFNELNDLLPVLADGLVWDDGFLGEAESCEFGAVSVGFREVFARCFASRGVELNELVGGGDGELWDFLGTSLDEVKPSLGEVPGETNGFPGKANGDQVTSPSPSPVPGFSPSPELTIFPGTVTGASSPSLIEYPQPSFKLKKLNQAVKIKPTGVQLWKYLGLNPLSGPKNLRILLVSLTATAAESRYFLSSVIQHYGHCKLGAISLVGDGILSIPAPSGETEYYELVGARLTELARTLQEEYVALPADAPEREQPIVLLFADFFGGARAVVETARLTKVFEFNVTLFHKKKDRLPIRVVQHVVPGDFFAQPETISVISAARLERFVLTMYNKIPGAPFATLLKTLPKSIAFRVGSHPKASLMSEDVYIHLAYERSIDKNWCVAVWLDQWGSSRLTKAWYCSPSLGKLGNPSTGLIKSFEDVSNDIWQETLRLTRGHGGNKFLVLTRLSNIIPDDELVQWRRLSSNNKNKDLSLIVMAVNPSLKTLVRAQRPDACVLGMPHTAYEDTDATLVDLADAVSGAVLRHPLALSNQQTRMALQTGLLMKPASDSDDMLVFELNLLSCSGSCSSTELLRAMMAQYRNLAALSAVWGVAREPSLVPWHVLAVQKCLRFLVHLRVEQ
Length1273
PositionKinase
OrganismBabjeviella inositovora NRRL Y-12698
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Babjeviella.
Aromaticity0.08
Grand average of hydropathy-0.146
Instability index43.21
Isoelectric point5.21
Molecular weight139365.90
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10172
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.24|      25|      28|     737|     763|       1
---------------------------------------------------------------------------
  717-  738 (35.42/17.12)	ELWDFLG.TSLDEV.KPS..LGEVPG.
  739-  763 (49.61/25.93)	ETNGFPGKANGDQVTSPS..PSPVPGF
  768-  792 (38.21/22.90)	ELTIFPGTVTGA..SSPSliEYPQPSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     212.02|      65|     722|     115|     190|       2
---------------------------------------------------------------------------
  115-  182 (105.81/84.17)	RLTLEKAVaPFGNHCVSLLPAdrRCVVLIDPILTPQGDLY.LNICSKEHHLRTFKELPSDSSDP....EDVSE
  235-  304 (106.21/59.56)	QLTWVRLV.PNLNHLNNLTPA..ICQFLQNGFANTKLVIWpLELCYVQGAVATAAMEMAEFSDPlrwvDDFSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     207.55|      62|     164|     651|     712|       3
---------------------------------------------------------------------------
  651-  712 (108.19/63.14)	NPTIRFNELNDLLPVLADGLVWDDGFLGEA....ESCEFGAVSVGFREVFARCFASRGVELNELVG
  817-  882 (99.37/57.41)	NPLSGPKNLRILLVSLTATAAESRYFLSSViqhyGHCKLGAISLVGDGILSIPAPSGETEYYELVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      90.65|      15|      15|     401|     415|       4
---------------------------------------------------------------------------
  385-  399 (21.44/11.51)	EAARDDTASEPRPED
  401-  415 (25.50/15.18)	NDARTDAVTDTEPDA
  417-  431 (22.59/12.55)	NDTHEDVVNNARVDA
  433-  447 (21.13/11.23)	GEACADAVSAATNTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.60|      14|      15|     460|     474|       5
---------------------------------------------------------------------------
  460-  473 (26.98/ 9.69)	PP.SPALLDIPMDKM
  476-  490 (24.61/ 9.31)	PPkTPGCYRDPGAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.66|      13|      34|     576|     588|       7
---------------------------------------------------------------------------
  576-  588 (25.06/15.75)	PNNNDDLV...RGSPS
  609-  624 (19.60/10.54)	PNIDEKPVkraRGEGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.82|      25|      43|     916|     943|       9
---------------------------------------------------------------------------
  916-  943 (39.05/37.32)	DFFGGAR..AVVETARLTKvfeFNVTLFHK
  960-  986 (39.77/28.21)	DFFAQPEtiSVISAARLER...FVLTMYNK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10172 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MGLVTAISSDETGSDSDADSHSDGPETHAHTSTPSKRAREPEPNNNDDLVRGSPS
2) TARSVLSPVPLSPAPPSPALLDIPMDKMIQPPKTPGCYRDPGAPLPIESPNPPMRRQSAFSPLTF
3) TEGDFNFFDEYPSGEAARDDTASEPRPEDVNDARTDAVTDTEPDAANDTHEDVVNNARVDANGEACADAVSAAT
534
446
371
588
510
444










Molecular Recognition Features






MoRF SequenceStartStop




NANANA