<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10170

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDIVQPNGTSDVLKPANGSALCSGSAPALPAVTTNMLPLATLLQNFAEYAFSEISYLVATLPNLQQPDSIKKKKLLELFVRLRKDLVKLYVLVKWSARARDFQRLIQLMSFMRTEQGNLFNSVWGMKSIVPGLASAKLPNPDLMTALEVFINGRPQLPSHNLIRQSALSAKTILKTFRNLNVLLAIKLALADDLPPRFRNYQIRDGRVTFTVDREFVASVSIADDETQDETISPFFLIDFRFLFGFPDDRYVLDDALVTPLPAPSHVKLESLANAVLHRSGLPGLYTILHHYATTYKLYLVHKQLANMRQSGVWKGHLQHTYNIDQSTIVVTYWAARAALRSFLEIGLNRKFELSFRWSKDGEYVSTHSLTEGLTDTDFGLNIEQTLTEITNKHAELALRGIYQQMSAQLAVRDGPALIRMLSPGKLHYQLTHTQHTVVSIDSITGNVFLVNPTPLMVSFVTRINKDAAAVAKVAYNLIVMRLEILTLKISSVLSAVGWIRNDVVKVSSGSEDWAKLQFSASSALNVQFFRRREWPQGWFLICGVNGYSSNLHWRVAQLRAALGAWQIQWLAKINLLAETDVLCEPKNYKSYFDYETLAELAVVAANKITSHLVLEELKAQGCRLMSLRTPTLAADPAVHNLLRADKSESVIVIDKDSLTAVPGCYSTLFLKIKLAGRFLCLSLYGKLRARINLKIDGPLAIKFEPETGVFEIQTQVETLSMGSAASGTLLAETLGKLTTLLNLISILNVLQQSRVEILLTDLDSIRFRYDSEEATLCGLVGAGIRLELAPNNPHNLVAVQLDSILATHGIPTLIKALGGTLPLVKALREISTANQEALRDAASGEFLLPKIRFSLFTRELNHFQLQYAAYLAESSAAVMDPHDIHSGTATLRALEVIDLTVRLRRGYRGRTYLFVTSPAPFLREFWSFKTNPFQEGDEPMDVHPLETGVACAVSCASRVLGVLNREILARGGVP
Length975
PositionTail
OrganismBabjeviella inositovora NRRL Y-12698
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Babjeviella.
Aromaticity0.08
Grand average of hydropathy0.083
Instability index36.03
Isoelectric point8.90
Molecular weight108364.11
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10170
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.05|      23|     318|     476|     498|       1
---------------------------------------------------------------------------
  476-  498 (37.36/31.68)	YNLIVMRLE.IL.TLKISSVLSAVG
  795-  819 (30.68/24.40)	HNLVAVQLDsILaTHGIPTLIKALG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     216.80|      77|     489|     138|     233|       3
---------------------------------------------------------------------------
  138-  233 (101.81/90.15)	LPNPDLmtalevfiNGRPQLpsHNLIR...........QSALSAktILKTFRNLnvLLAIKLA...LADDLPPRFR...NYQIrDGRVTFtvdrEFVASVSIADDETQDETIS
  628-  721 (114.99/59.94)	LRTPTL........AADPAV..HNLLRadksesvividKDSLTA..VPGCYSTL..FLKIKLAgrfLCLSLYGKLRariNLKI.DGPLAI....KFEPETGVFEIQTQVETLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.41|      58|      64|     845|     907|       4
---------------------------------------------------------------------------
  845-  907 (85.05/68.14)	GEFLLPKIRFSLFTRELNHFQlqyAAYLAESSAAvMDPHDIHSGTA.....TLRALEVIDLTVrLRRG
  910-  972 (97.36/60.47)	GRTYLFVTSPAPFLREFWSFK...TNPFQEGDEP.MDVHPLETGVAcavscASRVLGVLNREI.LARG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.26|      31|     194|      49|      90|       5
---------------------------------------------------------------------------
   59-   90 (46.10/27.40)	ATLPNLQQPDSIKKKKLLELFVRlRKDLVKLY
  256-  286 (52.16/42.38)	ALVTPLPAPSHVKLESLANAVLH.RSGLPGLY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10170 with Med14 domain of Kingdom Fungi
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