<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10159
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MSDSPFNFKVLSSSEVTPMATPDNLSAVSPAFASFSPSALDVATAGLAGPHGASALRNAVEQSTNTVLTDDLQQDNITTAKRPLFGRSKSEAVQRRDIEEIVHILRRRPGAISELGIERIGRNNSLEVFKDEIDGGKRISLGGRIILIDIDLLLPSNKVTKVALSLASRLDVQSSVAQTRSDALLLADLQAPTLDSFARNVERLARHDKLSTNEIDNFEVLNGLYKNALQRIHEYEIGAGIDAENAGHGTPVVDDAGVLGLSIWYCNERHRVPESLPESERKRYRAIVEIEESGGAGAGWGVVQNNALLGEQVATSDGEINWQEPDYSNLEDQATGYVLRLDPPVAIPYYDAAILDPECEAEIETISTFDGSKDSLVFAKRTTYNSRGQPEEYIFSLTSTRVAEMRRIEEVYMSHPRQIFSVFEILRQSIRVQALINSVFKPESLIPKSAVPMELPSTLAEFVSSLDNLSNMADLTESAPRTRAPPAMVSVKLTTPYGRAPQLSLSMPTTDSTAVDRQPRLTSFAVEVQRGGKIDVVGLAVNEHGDVEGKEEMERTLEDVIDIAEDLGIVALWVREQVR |
Length | 579 |
Position | Middle |
Organism | Lipomyces starkeyi NRRL Y-11557 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Lipomycetaceae> Lipomyces.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.259 |
Instability index | 55.22 |
Isoelectric point | 4.81 |
Molecular weight | 63451.55 |
Publications | PubMed=27535936
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP10159
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 375.75| 123| 308| 2| 132| 1
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2- 132 (183.69/145.77) SDSPFNFKVLSSSEVTPMATPDNLSaVSPafasfsPSALDVATAGLAGPHGASALR..NAVEQSTNT.VLTDDLQQDNITTAKRPLFGRSKSEAVQRRDIEEIVHILRRRPGAISELGIERIgRNNSL..EVFKDE
316- 443 (192.07/130.08) SDGEINWQEPDYSNLEDQATGYVLR.LDP......PVAIPYYDAAILDPECEAEIEtiSTFDGSKDSlVFAKRTTYNSRGQPEEYIFSLTSTRVAEMRRIEEVYMSHPRQIFSVFEILRQSI.RVQALinSVFKPE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.69| 14| 15| 490| 503| 2
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490- 503 (25.77/15.87) SVKLT..TPYGRAPQL
506- 521 (19.92/10.64) SMPTTdsTAVDRQPRL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 68.83| 19| 48| 242| 260| 3
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242- 260 (34.14/20.12) DAENAGHGTPVVDDAGVLG
292- 310 (34.69/20.55) ESGGAGAGWGVVQNNALLG
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