<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10156

Description Mediator of RNA polymerase II transcription subunit 11
SequenceMSKCNFVDEESIDLSSVPINSEEIEVRLDSLHEIDLRIIELLEAASKSLSLMTEATKKPSSPINTAESKATFEKSSQSYFELLEEVSVSLRKEIKLLNEVSKDKVLPISVDAKAEWVGKAKESEIYTHIDTLLDIKNRIILEEGKMKEKEAPNTEVKIMSVEDTDIKMEDIDSKIINVQPENTGNNDIEMENTQIENNAKRTETETTEMEIDTTGNFNEDLNPQNIKAESPGQDKTEKVQVGNENSEEEKAFGTDYKEFTHDLKRTESTVEPVANVETIEQVTEIASTESATEKENASDEKTMTANTISGSPKPTGLDNGTDGNSNVKETFENNTIIDSSNGNLDEEGISGGISDEENAPNTKEKEEENENYNNI
Length375
PositionHead
OrganismNadsonia fulvescens var. elongata DSM 6958
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetales incertae sedis> Nadsonia.
Aromaticity0.03
Grand average of hydropathy-0.872
Instability index51.68
Isoelectric point4.32
Molecular weight41728.10
Publications
PubMed=27535936

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10156
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     158.95|      42|      42|      40|      81|       1
---------------------------------------------------------------------------
   16-   37 (19.76/ 6.51)	........................SVPINSEEIEVRL...DSLHEIDLR
   40-   81 (65.79/37.02)	ELLEAASKSL....SLMTEATKKPSSPINTAESKATF...EKSSQSYFE
   83-  128 (43.07/21.96)	..LEEVSVSLrkeiKLLNEVSKDKVLPI.SVDAKAEWvgkAKESEIYTH
  131-  157 (30.34/13.53)	TLLDI..KNR....IILEEGKMKEKEAPNT.EVK...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.43|      21|      27|     300|     323|       2
---------------------------------------------------------------------------
  300-  320 (37.14/19.80)	EKTMTANTI....SGSPKPTGLDNG
  328-  352 (28.30/ 7.83)	KETFENNTIidssNGNLDEEGISGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     153.33|      40|      41|     216|     255|       3
---------------------------------------------------------------------------
  164-  206 (51.12/25.01)	TD.......IKMEDIDSKiiNVQPENTGNNdiEM.ENT.QIEN.NAKRTETET
  207-  253 (56.98/28.72)	TEmeidttgNFNEDLNPQ..NIKAESPGQD..KT.EKV.QVGNENSEEEKAFG
  254-  297 (45.23/21.28)	TD.....ykEFTHDLKRT..ESTVEPVANV..ETiEQVtEIASTESATEKENA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10156 with Med11 domain of Kingdom Fungi
Unable to open file!