<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10149

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMTTEEEKIYISLRPENHTRNEKPTIAQIIPRIIQERGSFIDITEESLLHEIESSASAEEQDSNRLHKTQTSDYPVKVEPAIEDENSENDDSVSRTKPEIEDAKSVNVGDEEEDEDEVDDIEEDGPNSIPIIGDSSIKDSESPEVAPTAANVWCKRPTNQEEFDQARTELVRLIGVAQNESALAQDFVSLLISCARPAAGTTSMSPHLKSHVAVGSLGADKTKSKPIADDSLIGIGWKIESLNKASEAMNTSASRLRLEVDKEKNYWKSIHTIASSGEILFKVRKGDSRGLGIKFGFGDAGSDYKDKGVATVRRRGDGTMYFKTNGERRSKVVQISIYKKVDGEVIKQGVSSSNILLPENDVNNEIKNARTLLFEEELFYVIANEARPLTSHRISINNGKITVDLQDEEIDIEFVEPNDVRDNDDDQYLPNSRRAELIATTLRLLLNYSHAKHLRQKHSDPEPLRTVDKRLRHTSYILRPLLCYIQHHKILKRTTRSLDQMVENYKGISYSVEKYVKNMSYLGRILFPPSSTCTLSFYNGVEVKIIIVSTLTNQQLPLYDVKAYCNKENTILSKSGFYQLSELEDWIKWVVDKKPIV
Length596
PositionHead
OrganismNadsonia fulvescens var. elongata DSM 6958
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetales incertae sedis> Nadsonia.
Aromaticity0.06
Grand average of hydropathy-0.594
Instability index52.96
Isoelectric point5.30
Molecular weight67291.71
Publications
PubMed=27535936

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP10149
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.72|      28|      28|      58|      85|       1
---------------------------------------------------------------------------
   54-   83 (41.07/20.29)	SA..saEEQDSNRLHKTQTSD.YPVKVEPAIED
   84-  113 (34.34/15.96)	EN...sENDDSVSRTKPEIEDaKSVNVGDEEED
  114-  138 (26.31/10.79)	EDevddIEEDG.......PNS.IPIIGDSSIKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.24|      11|      31|     236|     246|       3
---------------------------------------------------------------------------
  236-  246 (19.26/12.48)	WK.IESLNKASE
  266-  277 (15.98/ 9.18)	WKsIHTIASSGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.96|      16|      31|     474|     504|       4
---------------------------------------------------------------------------
  474-  492 (23.92/49.69)	SYILRPllcYIQHHKILKR
  508-  523 (28.04/11.40)	SYSVEK...YVKNMSYLGR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10149 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FIDITEESLLHEIESSASAEEQDSNRLHKTQTSDYPVKVEPAIEDENSENDDSVSRTKPEIEDAKSVNVGDEEEDEDEVDDIEEDGPNSIPIIGDSSIKDSESPEVAPTAANVWCKRPTNQE
2) MTTEEEKIYISLRPENHTRNEKPTIAQIIPRIIQER
39
1
160
36










Molecular Recognition Features






MoRF SequenceStartStop




1) IIPRII
2) IYISLR
3) NSIPI
28
8
126
33
13
130