<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10146

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMSQNTFKRGSCASRIAWSKTGPIAYITDKGVQICSLYCSDGEKWELSKPFTLTQVPIVHGGVPIVHLSFSPGNTSLACIDSRGQLSIWMVSVASSDVTCVYSPPSEALTSTNEMELNSIIGFSWLDPSKTIVLADRTTIQPNPEHTEGLRNRSISTYSITTANVLGPRHPLPNKYAAVAFTRRGVLKLFSQNTSGNKFYENSKALCPGENAVFLIASFGEWRDESFLLAGTVIGTGEVRLWSVSIDWNTNPPANQPHENIPTNPGNLVAKRVTSESFGAPSPIYELTHIHCMSSRQSDTCDMEIWMIWSGSDNTSIIKRYDLLKSETDLHESFYSLNLQNGAADQSISVSRDNERSFSLKEERIIEDKTVLNITSHLYDTFVNVCYSDGTIETTYREQEPTGNIKGILTLQEVGFAHSPGEIGSEICLSPSLLSFVSLNNEGSLSFHHIKYTASYDANSLYSVAVAFALRHAVACFSSILCDDIFILFQEFIKELETSAPHYKDEFVWVLLEEAHKSINYNLDIPVDHPVEKVMMNTSLQRLFSLQASVFTKKNFYYPIAGRIAMCYLNLRLLTFALTFTLRAASQVRPNIPDNELKAGHIHANTGFARWCTDFLVFICKELFEASQTPNCSLYDENNESLPMTIILSKPSRMFLIFSLRGIRGLEQIALRASQNEEATPGASMAARTAYRRFKDVISNTPVPLAPIEKLLNDVDNALKNIYPNLPDRRKLEYQLVFEGKIPHEFSPIAKRICDAWTKNIKPEVNIPKLYFHDVSWLGLDDSGFASLAKKSTNYFFLPEEESGKIKTDFLRKFIINHDSKLRSCTRCKGLSVYDDAKALSLSYWSVANQRSCLCGGSWIADASKHNAK
Length868
PositionTail
OrganismNadsonia fulvescens var. elongata DSM 6958
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetales incertae sedis> Nadsonia.
Aromaticity0.10
Grand average of hydropathy-0.192
Instability index48.04
Isoelectric point6.29
Molecular weight97128.24
Publications
PubMed=27535936

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10146
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.12|      30|      38|     702|     739|       1
---------------------------------------------------------------------------
  702-  736 (43.69/39.64)	VP..LAPIEKLLndVDNALKNIYP..NLPdrrKLEYQLV
  741-  774 (50.42/23.39)	IPheFSPIAKRI..CDAWTKNIKPevNIP...KLYFHDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.30|      26|     218|      74|     100|       2
---------------------------------------------------------------------------
   74-  100 (43.15/36.85)	TSLACIDSRG....QLSIWMVsVASSDVTCV
  287-  316 (47.15/34.99)	THIHCMSSRQsdtcDMEIWMI.WSGSDNTSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.04|      26|      37|     614|     642|       4
---------------------------------------------------------------------------
  614-  642 (39.93/36.66)	FLVFICKELFEASQTpncSLY.DENNESLP
  654-  680 (39.11/25.19)	FLIFSLRGIRGLEQI...ALRaSQNEEATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     159.89|      53|     346|      14|      73|       5
---------------------------------------------------------------------------
   14-   73 (79.55/68.70)	RIAWSKT..GPIAYITDKGVQICslYcSDGekwELSKPFTlTQVPI..VHGGVPIVHLSF..SPGN
  363-  421 (80.34/46.81)	RIIEDKTvlNITSHLYDTFVNVC..Y.SDG...TIETTYR.EQEPTgnIKGILTLQEVGFahSPGE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10146 with Med16 domain of Kingdom Fungi
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