<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10145

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMESPDISAVPVEALEQLRLRLTQVTHSLGKLQAQLHQPSLPSWPSLQSQFIILLTQLISLSQTLSLHSDILQQTVAYPLPNFPSRTEEGLLTTLLRKKPLPEVEKWVNNGHELAQGIKVKDVEDFCSWAAEVVRDIRDNHMWFGFSTQRELDDGAVAEEYTLKAAEEDDGGIPVDKVLQFMYQGREPSAQQVIPPRPFNAMRN
Length203
PositionHead
OrganismNadsonia fulvescens var. elongata DSM 6958
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetales incertae sedis> Nadsonia.
Aromaticity0.07
Grand average of hydropathy-0.345
Instability index46.45
Isoelectric point5.02
Molecular weight22937.80
Publications
PubMed=27535936

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
protein-macromolecule adaptor activity	GO:0030674	IEA:EnsemblFungi
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:EnsemblFungi
TBP-class protein binding	GO:0017025	IEA:EnsemblFungi
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi
transcription corepressor activity	GO:0003714	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10145
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.66|      16|      18|      74|      89|       1
---------------------------------------------------------------------------
   74-   89 (29.38/20.16)	TV..AYPLPNFPSRTEEG
   93-  110 (24.28/15.52)	TLlrKKPLPEVEKWVNNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.36|      11|      17|      39|      49|       4
---------------------------------------------------------------------------
   39-   49 (21.67/11.26)	SLPSWPSLQSQ
   59-   69 (18.70/ 8.95)	SLSQTLSLHSD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10145 with Med8 domain of Kingdom Fungi
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