<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10139

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMSAEVIFLEKKLENLTRGCVRRGVSAEKFLKLIKLLPEKVTANHIKFTESVLAARTSLFVDPDICVYLAYLAFQEDSTLPLNKLLEYLRTVNEPSQPQILIFLANSLRSWENASFETLIETLKALTLYMNDANDKSSLLWSFNGTNGVIALGTLISELGKYKIFAPIFDSELTNELSERNYRSDFRVAIQEFVKILKELESYFESEISLYYNLTGGSTANSISSATALTGTITKPSRVFRFMWLESLMLSSSYIQSESLVVQIKQLLGNESPQKLVSDLIMTSFDCLVISLSRKDPAKYHNLWRAFIIKKLPDLIRSILHTNNQHSEQVITQPIHSLDSCTVSLLRTNGDNNGDALDEMFSSFPATSSDIRHEFLKACIALKLISTKAYYHTLGEDAAVDEDFTAIEIDDGTNYTMIDESNGSGLVIPISEFVTSICQENFEFIGLEDSKIWKLIVSFETMEGPKQANISKSLLDLWKQMISSEDWRLVRYFSQSLCLNISSLDALVLHIPPAQFLNPLLEVVESWVDDEDEMNFQDTYTDFGCMLLFITTLYQRYNLTIPRTAKQPSFVYNMLHDSVDVNTLATQASDYLGGWITALFDAGGISDDLMRSATIKDCYKLVPVIFQQAIMASEKGLLDTDTLKGGLEYFLQPFLLGTLISTFRWLSSYLWLSTDVTVALRIIQSLVLTSELTNDISPIHKMVLAVSADDIYFALKDLIQRDIHVDSNLVDALSSYLSVHHRPLNPLFEEENNPGVMIGGGSGSRGRNAQIPPTSSILSIAKSQLSGLASWLNAVESQNHQGNTAVGNSSSLTPPFYNSKYLSLAINLLGPETVLDSFVNEILANASQDNDHVNIEVLSAVIVTIKPSKFSKNTLIQLLNDRNAVLSKMNDGGSNHKESKAENIRITALNKRVNELKVWCRDMVLVGCNKPDNTAAICPSTVQSPFEEDKMEE
Length952
PositionTail
OrganismNadsonia fulvescens var. elongata DSM 6958
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetales incertae sedis> Nadsonia.
Aromaticity0.09
Grand average of hydropathy-0.029
Instability index43.78
Isoelectric point4.94
Molecular weight106397.12
Publications
PubMed=27535936

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10139
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     215.35|      61|     131|     756|     819|       1
---------------------------------------------------------------------------
  756-  819 (98.09/56.90)	MIGGGSGSRGRNAQippTSSILSIAKSQL...SGLASW...LNAVESQNHQGNTAVGNS..SSLTPPFYNSK
  821-  860 (22.47/ 6.13)	.....................LSLAINLLgpeTVLDSF...VNEILANASQDNDHVNIEvlSAV........
  888-  949 (94.79/48.11)	MNDGGSNHKESKAE...NIRITALNK.RV...NELKVWcrdMVLVGC.NKPDNTAAICP..STVQSPFEEDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.90|      13|      72|     118|     144|       2
---------------------------------------------------------------------------
  118-  140 (15.49/28.66)	LIETLKALtlymndandkSSLLW
  658-  670 (27.41/ 8.60)	LISTFRWL..........SSYLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.97|      45|     131|     475|     520|       3
---------------------------------------------------------------------------
  467-  511 (77.27/49.00)	ANISKSLLDLWKQMISSED.WRLVRYFSQSLC..LNISSL.DALVLHIP
  513-  561 (66.70/36.67)	AQFLNPLLEVVESWVDDEDeMNFQDTYTDFGCmlLFITTLyQRYNLTIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.03|      43|     517|     167|     224|       4
---------------------------------------------------------------------------
  167-  224 (57.11/71.23)	IFDSELTNELSErnyrsdfrvaIQEFVKILKELESYF......ESEISLYYNLtggstANSISS
  686-  734 (65.92/44.42)	VLTSELTNDISP..........IHKMVLAVSADDIYFalkdliQRDIHVDSNL.....VDALSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.47|      24|     165|     414|     465|       6
---------------------------------------------------------------------------
  390-  413 (40.05/74.44)	YHTLG.EDAAVDEDFTAIEIDDGTN
  441-  465 (37.42/17.27)	FEFIGlEDSKIWKLIVSFETMEGPK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10139 with Med5 domain of Kingdom Fungi
Unable to open file!