<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10136

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMQDTFHQKLSSIVKILKSSPGSVTVQNIQRLSNIHKFETFIETINDKVKRLSIAGKILVMDIDFIELPSKNKDQTRFELNDVRLILANNNNSFKYVNTENGENILKNCLLNYPDLSKFDETLETLSIFDQVSHDDFDLFDYYMKIYDAFHQIPEFDVKMNTNDKFTIIVQDMFEVSLVNDERLNLSRIEYNGEWNDKKQKINDVGLQVKFIGDVSIAITKNILLQNDLIFDDSKKKKLFDSNEVFKSKKNSNLTFQGFQFLESEVLLISEVFSNDLPSLMKVLVELHKFSKLERFIEQLKQNFTLIDKFADLENEDVRLNDFLNGESIDEIEVEHHFITMSLKQQQIELKSDDSEYNFTIDTSIQHKLDEGLEKLKGILEK
Length381
PositionMiddle
OrganismWickerhamomyces anomalus (strain ATCC 58044 / CBS 1984 / NCYC 433 / NRRL Y-366-8) (Yeast) (Hansenula anomala)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Wickerhamomyces.
Aromaticity0.10
Grand average of hydropathy-0.412
Instability index39.17
Isoelectric point4.89
Molecular weight44531.03
Publications
PubMed=27535936

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10136
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     126.89|      37|      81|      60|      99|       1
---------------------------------------------------------------------------
   60-   99 (57.79/42.55)	MDI.D.FIELPSKNK.DQTrfeLNDVRLILANNNNSF..........K....YVNTE
  105-  142 (37.55/19.95)	LKN.C.LLNYPDLSKfDET...LETLSIFDQVSHDDF..........DlfdyY....
  143-  181 (31.55/15.62)	MKIyDaFHQIPE...........FDVKM...NTNDKFtiivqdmfevS....LVNDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.32|      40|      48|     243|     289|       2
---------------------------------------------------------------------------
  243-  284 (58.41/33.78)	EVFKSKKNSNLTF.QGFQFLESEVLLISEVFSNDlpSLMKVLV
  293-  333 (60.91/36.97)	ERFIEQLKQNFTLiDKFADLENEDVRLNDFLNGE..SIDEIEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.84|      22|      33|       3|      25|       4
---------------------------------------------------------------------------
    3-   25 (32.43/23.90)	DTFHQKLSSIVKILkSSPGSVTV
   38-   59 (35.41/21.54)	ETFIETINDKVKRL.SIAGKILV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10136 with Med1 domain of Kingdom Fungi
Unable to open file!