<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10135

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMSVGYSSMKHSRSDHKISWSKNGFIAYSDPTSTSNLSITKLESIRGSTWRLAPKKIFQIKTNPNSRLSSITNVYWSTSGMDLAIIDELGNITILSTGVLKNTSSHQLSCFEDVDIIYQDETCERLNTSKQSRISTGDSTTKVIAFKWLNVDKPIISNSPAVRVLTSSDSMVSSGAAADGAAASSDSSGYAYSYAVHQYKSYGTLHPIQGKSGFFTVRRNGEVDFHYQLNNAGFDFKKTTVLLEDVSDLKTLWLEHASIGFNRDGSVIVACFSKLTKSLRVYKIVVNWGEINPNDKLKAPLTLSVEKLISEPLSVIGSNGFPQELSGIDIISPNFSLDTELELLLTFEGPGVTGGETLLQKFQISNEYKNLRFKNESNGYSNGASTSVDNYYTLVQTGETILDNRVLDISFKNFDFMIVLTLRNGEIQLRNRKNLHIIGNGGQKEVIPSAISTLLDAGFKFELPESVPEAISVSPNLCGFVAMNKNNTLEYKATTRPQHEMKKGEILTLSAAFGCKYSSACFTNMSSDDLIIAIQDEILKIPDPNIKDQLILAILQESHRALNFSLDHSKDQIDRLLVNPPIQKLLSLQYSLGKLQPTNETSSIALAILNLRLVAFSIMLSLRTLFHHQQRVTKKGSETLMDAIYRSENILSTLGTINWFIEFLIFTIQELMSCCDVNTSNKDHFDTIVFALLLSKIPRSLIIYSIAGIKRIDGFLQKIQELNNANSPGALNMEILNKSVERYKFLLSLIDLERYEKFLIDIESIFQRNLEKSAALSIEQTLIFQNKIPSSYLGSIGVILNKFQEQFQDTSNLAELYFHDTRWLHFQISNNPKVSKILLKPTDKVPILFNLNDTLIDDVTKVVITNKEKLKKCLRCEYITANDTEGFFSSAIKGGANSNANLNHWPVAFHRTCLCGSCWVYIDHSEVTGF
Length929
PositionTail
OrganismWickerhamomyces anomalus (strain ATCC 58044 / CBS 1984 / NCYC 433 / NRRL Y-366-8) (Yeast) (Hansenula anomala)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Wickerhamomyces.
Aromaticity0.09
Grand average of hydropathy-0.132
Instability index32.47
Isoelectric point6.70
Molecular weight103846.30
Publications
PubMed=27535936

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10135
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     336.83|     116|     200|     173|     303|       1
---------------------------------------------------------------------------
  173-  303 (173.94/161.75)	SGAAADGAAASSDSsgyaYSYAVHQYKSY..GTLHPIQGKS.GFFTV..RRNGEVDFHYQ..LNNAGFDFKKTTVlledVSDLKTLwLEhASIGFNRDGSVIVA.......C.FSKLTKSLRV.YKIVVnwgeiNPNDKLKAP..LTLS
  376-  509 (162.89/111.15)	SNGYSNGASTSVDN....YYTLVQTGETIldNRVLDISFKNfDFMIVltLRNGEIQLRNRknLHIIGNGGQKEVI....PSAISTL.LD.AGFKFELPESVPEAisvspnlCgFVAMNKNNTLeYKATT.....RPQHEMKKGeiLTLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.26|      20|      20|     529|     548|       3
---------------------------------------------------------------------------
  529-  548 (34.85/23.01)	LIIAIQDE...ILKIPDPNIKDQ
  549-  571 (28.41/17.42)	LILAILQEshrALNFSLDHSKDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.55|      42|     199|     580|     680|       4
---------------------------------------------------------------------------
  580-  621 (66.81/107.96)	PIQKLLSLQYSLGKLQPTNETSS...IALAILNLRLVAFSIMLSL
  704-  748 (62.74/15.57)	SIAGIKRIDGFLQKIQELNNANSpgaLNMEILNKSVERYKFLLSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.35|      32|      35|     103|     134|       5
---------------------------------------------------------------------------
  103-  134 (56.26/35.56)	SSHQLSCFE..DVD.IIYQDETCERLNTSKQSRIS
  138-  172 (43.09/25.63)	STTKVIAFKwlNVDkPIISNSPAVRVLTSSDSMVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.40|      10|      23|      40|      49|       7
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   40-   49 (18.48/12.63)	KLESIRGSTW
   66-   75 (18.92/13.13)	RLSSITNVYW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.74|      14|     462|     355|     368|       9
---------------------------------------------------------------------------
  355-  368 (25.09/14.45)	ETLLQKFQISNEYK
  819-  832 (28.64/17.46)	DTRWLHFQISNNPK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10135 with Med16 domain of Kingdom Fungi
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