<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10128

Description Uncharacterized protein
SequenceMDWRNELTNNERLRYVGVLVQALKELALTANNNNPAAFDVNKLKTSAGEFEKYCYQNASNRISYVHFFKQKILSIKNSIQQQKLQKQQQPGGVGANTTGNIGVSNIQLGNNTNSNNNANIPNQQNQQLGGTPNLNAGAPTPNQSQLFLAQQAQARQAAQQMRNQTPLQGANANVPGQQQQQNLQNAGLNAGLNYNNQIPQQQQQQRGNQTAPSQQQQQVQNSTNNSAQAALNVNMKTVPIPMALLQRIPNLPPNVNTWQQIFELVASRQLDSEYIGIIRQVYTIHTQLIQKQQQQQKQFGSNQQAPSTTAPTTGANMGVNAQIARQQEELRNRQLQQQQQQQQQQQQNQMPQQQQQQQQQQQQLQHNNANPQQQPQQQSAIPQLTPDLLQRLTENALQLLTKLQQEKQIPDNLTNEQRNMFIKRYISRQQQLRMEAYTKQQQQQQGANNGGAQNLNQQVVNPTGATQSRPVNQAQLQARLQNANNLAQQNQQQASQNQPNQQQQRWNEQGNNNNNNSNSNNNTTNNNVQMKLNNLPTGLTAEQQQQLNARRQQALYQQQLQQQQQQQAARGANLNTNVNQTVPGAANSNAVGGAGAGAVQNPILKNNVLVPTEQDRVELRMILNEVSKVPIKLTNLTAQLTPEQKSVVSSKVHSLLLPLFNLIEQLVPTFYTLTKNVDGTKKLLHMRFMVKEVLDGLRRNEYYASPELLEKVKAQSQKYVSFVKEQISRKNAAAAQAGGANANVNTGNANNAAINNNNNNFNINPQITPQQLLQRKQQQQQQASQLNPQITPQQLLQQQQIGTQPSQFINNNNNNNNNNAEFNPLELTNIPGSSSNNNNNNNGNFQNVDMSMINGGRLNTPDLSQMNVTPKLNQMNISGVAPSPAMGNANFGTTPNFSGSPQMMNAGVFNNNNNQQQPQPQPQPLVQGTFTQQPPAPQPIQPQQSSTPAASTPTTKKAPAKRKSTKGRKTSNASTPTLAPKSVPAPTAANGPTPGATGVSAPTGQATINNNSTPTTTLANVGGAAPGTIAPTALQAQMLKKEQEMISKEDQNKKQFEENKAKRMESYHTKPIDFFAASLANLLELKDEESKILNDSKKKTNGDFKSSPAQKGLTPSTILQTPLTFSNAAKTPNSTTKGGIPNGVSNASTYLSPNLSPSSTLKNVNGDVSTKWGPRVSREAIQKTFGNVEEIKKLLFVDEQENSNGEESGPMIPTPPPDNEKQSKEQKDSVDDDRKFKKIKIDDDNRFYDENDNQLNSDLMWDFDYVSSHIDDDDSTQPDFYINI
Length1284
PositionTail
OrganismWickerhamomyces anomalus (strain ATCC 58044 / CBS 1984 / NCYC 433 / NRRL Y-366-8) (Yeast) (Hansenula anomala)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Wickerhamomyces.
Aromaticity0.04
Grand average of hydropathy-0.986
Instability index52.68
Isoelectric point9.60
Molecular weight141952.17
Publications
PubMed=27535936

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
xenobiotic metabolic process	GO:0006805	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10128
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.98|      17|      17|     336|     352|       1
---------------------------------------------------------------------------
  336-  352 (35.83/10.72)	QQQQQQQQQQQQ..NQMPQ
  354-  372 (28.15/ 6.29)	QQQQQQQQQQLQhnNANPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.19|      22|      25|     813|     836|       3
---------------------------------------------------------------------------
  440-  462 (30.06/10.54)	QQQQQQGAN.NGGAQnLNQQVVNP
  821-  843 (25.13/ 6.74)	EFNPLELTNiPGSSS.NNNNNNNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     655.68|      73|      73|     473|     545|       4
---------------------------------------------------------------------------
   56-  126 (49.53/ 7.72)	........QNASNrisyvhfFKQKilS.IKN.SIQQQKLQKQ.............Q.................QPGGVGANTTGNigvS.NiqlGN.NTNSN.N...N.........A..............NI..P..........N....QQNQ
  128-  181 (59.13/10.84)	.......LGGTPN.......L.........N.AGAPTPNQSQ.............L.................FLAQQAQARQAA...Q.Q...MR.NQTP................LQ...G....AN..ANV..P...........G..QQQQQ
  185-  261 (81.93/18.28)	NAGLNAGLNYNNQ.......IPQQ..Q.QQQrGNQTAPSQQQ.............Q.................QVQNSTNNSAQA...AlN...VN.MKTV......P.........IP...MallqRI..PNL..P..........PNVNTWQQI
  262-  328 (71.90/15.01)	FELVASRQLDSEY.......IGII..R.QVY.TIHTQLIQKQ.............Q.................QQQKQFGSNQQA...P.S...TT.APTTG.A...N..............M....GV..N................AQIARQQE
  473-  545 (125.64/32.53)	QAQLQARLQNANN.......LAQQ..N.QQQ.ASQNQPNQQQ.............Q.................RWNEQGNNNNNN...S.N...SN.NNTTN.N...N.........VQ...M....KL..NNL..P..........TGLTAEQQQ
  547-  615 (47.25/ 6.97)	L...NAR...................R.QQA.LYQQQLQQQQ.............Q.................QQAARGANLNTN...V.N...QTvPGAAN.S...NavggagagaVQnpiL....K...NNVlvP..........T.....EQD
  616-  700 (50.67/ 8.08)	RVELRMILNEVSK.......VPIK..L.TNL.TAQLTPEQKSvvsskvhslllplF.................NLIEQLVPTFYT...L.T...KN.VDGTK.K...L.........LH...M....RFmvKEV..L..........DGL...RRN
  701-  763 (54.66/ 9.39)	EYYASPEL..LEK.......VKAQ..S.QKY.VS..FVKEQI.............S.................RKN.AAAAQAGG...A.N...AN.VNTGNaN...N.........AA...I....NN..NNN..N..........FNI......
  865-  914 (55.36/ 9.62)	QMNVTPKL..................N.QMN.ISGVAPSPAM..............................................G.N...AN.FGTTP.NfsgS.........PQ...M.....M..N...............AGVFNNNNN
  915- 1005 (59.59/10.99)	QQQPQPQPQ...P.......LVQG..TfTQQ.PPAPQPIQPQ.............QsstpaastpttkkapakRKSTKGR...KT...S.N...AS.TPT.................LA...P....KS..VPA..PtaangptpgaTGVSAPTGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.97|      16|      18|    1115|    1132|       5
---------------------------------------------------------------------------
 1115- 1130 (28.30/17.28)	P......STILQTPLTFSNAAK
 1141- 1162 (22.67/ 6.19)	PngvsnaSTYLSPNLSPSSTLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.04|      32|     405|     382|     419|       6
---------------------------------------------------------------------------
  382-  419 (42.35/28.61)	PQLTPdllQRLTENAlQLLTklQQEKQIPDNLTNEQRN
  788-  819 (59.69/24.90)	PQITP...QQLLQQQ.QIGT..QPSQFINNNNNNNNNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.98|      24|      27|    1218|    1244|       7
---------------------------------------------------------------------------
 1221- 1244 (40.04/40.02)	KQSKEQKDSVDDD..RKFKKI..KIDDD
 1246- 1273 (35.94/23.66)	RFYDENDNQLNSDlmWDFDYVssHIDDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.67|       9|      36|    1163|    1174|      12
---------------------------------------------------------------------------
 1163- 1174 (13.21/16.13)	NVNGDVStkwGP
 1202- 1210 (18.47/ 9.58)	NSNGEES...GP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10128 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAAQAGGANANVNTGNANNAAINNNNNNFNINPQITPQQLLQRKQQQQQQASQLNPQITPQQLLQQQQIGTQPSQFINNNNNNNNNNAEFNPLELTNIPGSSSNNNNNNNGNFQNVDMSMINGGRLNTPDLSQMNVTPKLNQMNISGVAPSPAMGNANFGTTPNFSGSPQMMNAGVFNNNNNQQQPQPQPQPLVQGTFTQQPPAPQPIQPQQSSTPAASTPTTKKAPAKRKSTKGRKTSNASTPTLAPKSVPAPTAANGPTPGATGVSAPTGQATINNNSTPTTTLANVGGAAPGTIAPTALQAQMLKKEQEMISKEDQNKKQFEENKAKRMESYH
2) KDEESKILNDSKKKTNGDFKSSPAQKGLTPSTILQTPLTFSNAAKTPNSTTKGGIPNGVSNASTYLSPNLSPSSTLKNVNGDVSTKWGPRVSREAIQK
3) KKLLFVDEQENSNGEESGPMIPTPPPDNEKQSKEQKDSVDDDRKF
4) KLQKQQQPGGVGANTTGNIGVSNIQLGNNTNSNNNANIPNQQNQQLGGTPNLNAGAPTPNQSQLFLAQQAQARQAAQQMRNQTPLQGANANVPGQQQQQNLQNAGLNAGLNYNNQIPQQQQQQRGNQTAPSQQQQQVQNSTNNSAQAALNVN
5) LLTKLQQEKQIPDNLTNEQRNMFIKRYISRQQQLRMEAYTKQQQQQQGANNGGAQNLNQQVVNPTGATQSRPVNQAQLQARLQNANNLAQQNQQQASQNQPNQQQQRWNEQGNNNNNNSNSNNNTTNNNVQMKLNNLPTGLTAEQQQQLNARRQQALYQQQLQQQQQQQAARGANLNTNVNQTVPGAANSNAVGGAGAG
6) QQQQQKQFGSNQQAPSTTAPTTGANMGVNAQIARQQEELRNRQLQQQQQQQQQQQQNQMPQQQQQQQQQQQQLQHNNANPQQQPQQQSAIPQLTPDLLQRLTENAL
732
1086
1192
83
399
292
1068
1183
1236
234
597
397










Molecular Recognition Features






MoRF SequenceStartStop




1) DFYINI
1279
1284