<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10126

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSGEIEVFKVSTNHLKLAHVPEIKYCVFTASNGEDQSILDAEVSLRKKNPKVLAVLYSKELWTFSMNIEDPPVPDLEFQLKQDPIKSFTSSSIYGTTDHNPSSLLPLTYVTFLRALKKMLILNLSSRGELVPFGNSGLLPDSKFLQLDPKLASRGDLFLSITTKPHELNKLQELSPDIDFNKNYAIYLAPSGIRAYLAGETLEYSKTTAPSNQNTIIETLLALHSIKLDPDKLTWLKMIPNLGHLNAITTQVSDYLRAVTNSKYLLWPLELCFVQKADEFTNGARDRLAESMNDQFSLIDDFANLRATSSFKTPSNIPTSNNTPIAFESPSTEPNIIKPHFERKASAVTETPAGTHDSWSDLDEELFGEGDGVTDADFNFFDNDDGERNDDVDLEQELDEALEQTGNEMSLDNTDSGPDIALEDKLSNDSDSRDNHFDIPIEEITIPGTPLYTDPGAPEPIQSPKNVARKKSIFSPLNFNPIIRSNVDNKYANGGKFFVSSVDTPTGEAAIPSLAGDKFAHVDDDTDDEDDDDEDDDDDDEENEENEEDEVFEDEAGQDGSMNVTDQEMKTESRSVMDRTPSIDTSASEKIPFVRDSTVNRLDSTEPEFKKLRLESAVPQLSEEQNDPSKDTRIPSPGIGANGSPNCVPFLLRSIPLHSIPSHFYSDTPTVKHDDLKPLLDTFLQQIIWDDGYLSEAIPKVDFFNDDYPESVQRAIAQFFPEIHEANLAELSGMSITDRMFKEYNHDNEIQAESPLSSFKNPEYVLSSNGPSTDTMDFAISSELPKDTEESSVDGAKLFFEIPEPRITVKRLDQEVSVNASALSLWNLMSFSSLKPSKDFRLLLVSPDNLVTESDYLMTDLLQIYHKCQLGNIERLQSSLVKKGVAPVDYHSDVFEESALSVARSLNESLIKGSNYKDIVITLVDFEQDLKSIIKLSQVFEKMKAAILAIPNDRKLQINVKLKIIPSTYISNNGALSILSINKLTKLSLSLYNDVCGENETYASLSFPLPSKINFQLTKTHIAGKLLSEDSFIHLAYGRSIDKEWCAASWTDQFGKMRKSKAWYCPSKVKNSLETVTNEMWDFTVQLSKSLPGKKFLVLTRTDGMIPDDELLQWKRLSSKSRELALVVVSVNENSKLLLTMDNPQYPLDKLFDQEKSFANTAGLTRIEAPNTVGSSTGLTPSTIFTPQPVNSPDLFTISRPSTHESPSDFRVTSDESSSIVNIADKVHALIYTNPSPLANSPTRLSIKTGFLIKPVPNSQNKLATFEINVLSCPGNLPCDEFMNMILIQYRNLATIGELYGVNDTQYHSLIPWHIAAVVKSLNCLVHVRVE
Length1331
PositionKinase
OrganismWickerhamomyces anomalus (strain ATCC 58044 / CBS 1984 / NCYC 433 / NRRL Y-366-8) (Yeast) (Hansenula anomala)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Wickerhamomyces.
Aromaticity0.08
Grand average of hydropathy-0.401
Instability index40.60
Isoelectric point4.65
Molecular weight148455.68
Publications
PubMed=27535936

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10126
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     555.81|     186|     213|     628|     840|       1
---------------------------------------------------------------------------
  636-  840 (301.54/233.63)	SPGIGANGSPNCVPFLLR...SIPLHSI...PSHFYSD..TPTVKHDDL..KPLLD...TFLQQIIWDDGYLSEAIPKVDFFNDdyPESVQRaIAQFFPEIHEANLAelsgmsitdrmfkeYNHDNEIQAESPLSSFknPEYVLSSNGP.STDTMD..FAISSELPKDTEESSVDGAKLFFEIP........EPRITVKRLDQEVSVN.ASALSL...WNLMS....FSSLKPSKDF
  846- 1063 (254.27/150.48)	SPDNLVTESDYLMTDLLQiyhKCQLGNIerlQSSLVKKgvAPVDYHSDVfeESALSvarSLNESLIKGSNYKDIVITLVDFEQD..LKSIIK.LSQVFEKMKAAILA..............IPNDRKLQINVKLKII..PSTYISNNGAlSILSINklTKLSLSLYNDVCGENETYASLSFPLPskinfqltKTHIAGKLLSEDSFIHlAYGRSIdkeWCAASwtdqFGKMRKSKAW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     429.03|     157|     213|     177|     387|       2
---------------------------------------------------------------------------
  141-  356 (208.29/178.07)	DSkFLQLDPKLASRGDlflSITTKPHEL..NKLQElspDIDFNKNYAIYLAPSGIRAYL....AGEtleyskttapsnqntiietllalhSIKLDpDKL......................TWLKMIPnlGHLNAITTQvsdylRAVTNSKYLLWPLELCFVQKA...DEFTNGARdrlaesmndqfsliddFanlrATSSFKTPSN...IPTSNNTPIAFESPST.........EPNIIKPHFERKASAVTETPAGTH
  357-  559 (220.74/115.61)	DS.WSDLDEELFGEGD...GVTDADFNFfdNDDGErndDVDLEQELDEALEQTGNEMSLdntdSGP........................DIALE.DKLsndsdsrdnhfdipieeitipgTPLYTDP..GAPEPIQSP.....KNVARKKSIFSPLNFNPIIRSnvdNKYANGGK................F....FVSSVDTPTGeaaIPSLAGDKFAHVDDDTddeddddedDDDDDEENEENEEDEVFEDEAGQD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10126 with Med13 domain of Kingdom Fungi
Unable to open file!