Description | Mediator of RNA polymerase II transcription subunit 7 (Fragment) |
Sequence | ISSLYPPPPPYYKFFTDESLHKFNELKSKTPSITEEQLPDEEKNLQYLIPPKPPSGETYRSFGNIWHFNDKIPRLEDMGIAQLYKESDIPNGEDSKFKIEELKKLLKSLLLNFLEIVGVMSVSPDQFVVKIEHIRTILINIHHLLNEYRPHQSRESLILLLEKQVETKKDEIKEIERVCNEVESKIKNL |
Length | 189 |
Position | Middle |
Organism | Wickerhamomyces anomalus (strain ATCC 58044 / CBS 1984 / NCYC 433 / NRRL Y-366-8) (Yeast) (Hansenula anomala) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Wickerhamomyces. |
Aromaticity | 0.08 |
Grand average of hydropathy | -0.574 |
Instability index | 56.24 |
Isoelectric point | 5.75 |
Molecular weight | 22171.24 |
Publications | PubMed=27535936 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery.
ECO:0000256 RuleBase:RU364060 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP10123 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 67.10| 22| 44| 12| 38| 2 --------------------------------------------------------------------------- 12- 38 (29.99/28.53) YKFFTDesLHKFNElksKTPSITE...EQL 59- 83 (37.11/20.75) YRSFGN..IWHFND...KIPRLEDmgiAQL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EKNLQYLIP 2) PPYYKFFTDESLHKFNELK | 42 9 | 50 27 |
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