<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10119

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMESEIRSQQPPEIPHITTNIIPLSDILRKFSEFSYAELSHIIQIQPTNEAKKKKLLELIVYLRQEYVRLYVLTKWSKISAQDFSKLIDLLAWLREQTNYFTNLIWATKSINQSLLSAKLPNPDIITALEVFTEGRPTLPSHNLIESKITPQKILQTLKDLNVILSMKFALVENIPDKFLNYEIKDGRIFIYTDDYEFQVSVIDDNSPFFMIDFKFNFGDFEPSRKLLRISNDALRIGGFNELNKILTNYTNTMKLYMIHLKLNGLKNIKHIYHADKFQIVIHYWINSYVFKNSYIEIGLNKDNNIIYRWFKQAQFVETFQDIGFIDDFLNVIYYKHAVSILDQIDDITVNKSVLQINEKTGLFYFKNSTPLMNSFLKKLNTDDFKNINMNLKLLRMDHKYMEISTILSVTGWIQNDIIKLAPHEVNKLGQEKLLNYQQKENTVFLSRNLKFYTRKEWPSNWFLVLLIDTKIKSFIGNVRSIAGQWTISSLNELNIETFDYRTSKGLIDYVSKKIILHLITNELGSAVYKIIKDDTILIQTDSFISIPDTSNTLYLNFKLEPNKKNMMLKLKGKLNNSLSLEDFVIDKNGVFEVFETVEFKRFSILANIIAKLQKLSKVIGLINFLKLESLNLLNVKLDEIVFKYGSQICTLRDGFDIELPTTNPHNICLVSIKRYLHKRGIGKLFKYLQESNVLVEKLNELATQESTDKNDYDPSKLRYEVIPKNLNLFTVMYYNNYKPERQCLDLNIEMKIKNGKYCYLITFDRDSEFKSEFTMKGELYNSMKHKFKLVPLRNGIMCDESGIDQVLGYFHDKIMTKLVN
Length820
PositionTail
OrganismWickerhamomyces anomalus (strain ATCC 58044 / CBS 1984 / NCYC 433 / NRRL Y-366-8) (Yeast) (Hansenula anomala)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Wickerhamomyces.
Aromaticity0.12
Grand average of hydropathy-0.217
Instability index34.21
Isoelectric point8.90
Molecular weight96112.44
Publications
PubMed=27535936

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10119
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     430.74|      92|     149|     176|     273|       1
---------------------------------------------------------------------------
  176-  267 (153.34/68.79)	DKFLN..YEIKDGRIFIYTDDYEFQVSVIDDNSPF..FMIDFKFN..FGDFEPSRKLLRISN.DALRIGGFN.ELN...KILTNYTNTMKLYMIHLKLNG.LKN
  326-  415 (112.00/47.68)	DDFLNviYYKHAVSILDQIDDITVNKSVLQ.........INEKTG..LFYFKNSTPLMNSFL.KKLNTDDFK.NINmnlKLLRMDHKYMEISTI.LSVTGwIQN
  431-  523 (107.85/51.12)	EKLLN..YQQKENTVFL.SRNLKFYTRKEWPSNWFlvLLIDTKIKsfIGNVRSIAGQWTISSlNELNIETFDyRTS...KGLIDYVS..KKIILHLITNE.L..
  531-  583 (57.55/21.92)	.........IKDDTILIQTDSF...ISIPDTSNTL..YL.NFKLE..PNKKNMMLKLKGKLN.NSLSLEDF.................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.97|      32|      60|     619|     656|       2
---------------------------------------------------------------------------
  619-  656 (42.05/38.37)	IG.LINFLKlESlNLLNVKLDEIvfkyGSQICTLRDGFD
  681-  713 (50.93/27.33)	IGkLFKYLQ.ES.NVLVEKLNEL....ATQESTDKNDYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.63|      20|      23|     280|     299|       3
---------------------------------------------------------------------------
  280-  299 (36.62/22.66)	VIHYWINSYVFKNSYIEIGL
  305-  324 (37.01/22.98)	IIYRWFKQAQFVETFQDIGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.54|      12|      28|      54|      65|       4
---------------------------------------------------------------------------
   54-   65 (19.55/12.59)	KLLELIVYLRQE
   85-   96 (20.99/14.07)	KLIDLLAWLREQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.63|      17|      23|      12|      29|       5
---------------------------------------------------------------------------
   12-   29 (24.96/21.05)	EIPHItTNIIPLSDILRK
   37-   53 (28.67/18.86)	ELSHI.IQIQPTNEAKKK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10119 with Med14 domain of Kingdom Fungi
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