<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10116

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMNGHIKSSDSENSPFHNLYLSLDPTTIGLALGERPVKSIEPNGVLVYEETKTSNAILSEQLGRVWDEYPNGLLDLTEEKIESLSPEEDAVETKNEIKVEEKRRDPSKMMKWEEMEQLRFIVDNQLNDARNHLFWALELCRTLSVSSSFTSQPPPPPTSFHQKKAKAKSVQPPSSALSAMTDAPPVLPPGTYTTTPTNPKQKESHIQIFELEQLLFAKQKTLDECQTLIDGAVNELCLMADAGENFWRDVKSLKEGKEGRGRWAIVPKPDFGRVMGDGETAKDIIVPYAIDEGKYGFSTRTRCLAGFDLDPTAQDSLMFSARHRLRFRVTLSDTSGVVTSSAPVEMENESDVRSKMEAAQMEAFDEDLLNEIRSEASDYPKNVTEPHFVSVPVANCTLSFELYDPKSSSSLPSSPLCDIILSAARLALINAHRQRKTNLVAPTLNYTSRVPTILKPILDALRFRQLCKVVQLNPDFDARGLLGTSRRGEKGISEWLYRVMEAVEQVNIQQVDKN
Length513
PositionHead
OrganismCryptococcus depauperatus CBS 7841
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Cryptococcus.
Aromaticity0.07
Grand average of hydropathy-0.479
Instability index49.61
Isoelectric point5.23
Molecular weight57433.36
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10116
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.47|      21|      95|     113|     139|       1
---------------------------------------------------------------------------
  113-  134 (37.58/36.64)	EMEQLRF...........IVDNQLN......DARNHlFW
  209-  246 (24.89/ 8.86)	ELEQLLFakqktldecqtLIDGAVNelclmaDAGEN.FW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     205.47|      66|     397|       6|      73|       2
---------------------------------------------------------------------------
    6-   73 (109.23/79.73)	KSSDS.ENSPFHNLYLSLDPTTIGLALGERPVKSIEPngVLVYEETKTS......NAILSEQLGRVWDEYPN....GLL
  405-  481 (96.24/63.58)	KSSSSlPSSPLCDIILSAARLALINAHRQRKTNLVAP..TLNYTSRVPTilkpilDALRFRQLCKVVQLNPDfdarGLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.85|      13|      30|     143|     155|       4
---------------------------------------------------------------------------
  143-  155 (26.50/14.63)	SVSSSFTSQPP..PP
  174-  188 (21.35/10.44)	SALSAMTDAPPvlPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10116 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SSSFTSQPPPPPTSFHQKKAKAKSVQPPSSALSAMTDAPPVLPPGTYTTTPTNPKQKE
2) TEEKIESLSPEEDAVETKNEIKVEEKRRDPSKMM
145
76
202
109










Molecular Recognition Features






MoRF SequenceStartStop




NANANA