<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10112

Description Uncharacterized protein
SequenceMPASSRHPPSVHHYGSKASAKLKLGGSKAPVQHLPVGEKNIYEDAEVEGFGPPTWRTVLHKQIDFGFPDFYPSRPGHNQPEDVLTEENVKSGFSGRPFVSEVAETFSMHGPIHQHLSSGCLDMLMNLGKELIEKQEESMPQIGERTFRIPVRVTYNDTKRLQFLSDLANPAVPLYRLMRTPVPHGFKGVEILDAMFSPATSIRQPASNMTLLADPIPIDRAVWFIRVIGANEISVHRTRQSTITSSVTAPSPVAATPSSTTTVNAASPMPASSNEWYSQEFTNTLIQWLRIQLGQLALPPEGQNTSASTTSKNLGSGILQDEKARAKWLIKWDYSTRLLREMHAKDLLSNRLFSGWLAEHLSQVNLAQLGFLAQLVGEYLSDMIRHLDSARHCIRAACEILTLLRESPVRDVLGKVEAMLSLYEANPDVLLSPVTWKRYSPLISSIIRNTTSQWTNLQRRNEALLFKPKMNENPFNPRRQQMEEITKLDSISENTNMLDLTRSYFDGASAPNIASLDLQRLEEKIFMLLDWAMGLFQLGSHRPYAAYTLLKHWQGQHKEYQARQSRPDTVDLFEILYKWLDTASAARDESNIEAIGITIGEMIRRGMFSYGRYLQTLIAAGQSARNRAQQELESHHLTLLKVMPTFVLAKELLQQRRIALSGDDEETRKKDDAEEEAILDAFKEDVKEYIPEIFGLETYGRSEELRQIVDYHLPSTSQMTRYLYVFVRPSITISANAIFSSQAGRSPMNASTFARITQVFRQCHGYATIADFMIRALLEAEDDDILDVVLDIIQRDADIWTSMDLWPRLGDKLLDRHHILESRGKEHVRLMKLLRNLVQKNRLMPDDQEEVNHLSLNIVRSPHSENLGLLSQDPLEILPQILLGGNKDIISTIAPALHRHYGFFHLWSSKWWTLIIDVIQKAESEQKLCLYRMISKHMIAVFQEYQESFDSIVGSWLSSLASARLLDIFGKHTSKIMTQLLLFLVSHRALSTTTIFDKMIYPIWKLTLMWALPPRKRLSSEQIQSIVSTIDLVSQLLVLPPLESELPPTLLTEAIVIQASRQNIFQDHHVKLLIQHMPVLVVFEQNQLLPEQTTTKIGEILNSLASSAEFKTAAFRHLSILKDAFLAREWSGPGMGQELEGRMVDVLKLIMSEKRTQSSPRTGIPSIDESGRFSAWQWTRIVLEMRLEFKALAMRIADGQEVVDAKCTLSQLVHLTLDRETNRDDTDLLCEVFRGVDTTITHEIVAAGMDRLSNLLGQAIGAETQQQLEAFIDSIHQILRIVHCTSRESTQPITESSVLIARHKLLDLLAVALQTIDRHMTTGVDFLLPQGISPPQPGHLLATVMTLLKFVLGTDTTDNGSLTAPKPNFPHLAVCFLKSIVASETIHDPDWIKEMCDMLAYIIDCTPFQSRLACQAILSNEIALLNTQSDFNFLPLLTSSILSITSIQRNMSLTTPDTIDDDTHNPSLLLDDRRWELFEYMAPPKRKIGPQDLFLSSITLKDHSSIPISLFSPRLTRDAPPNVGTMDIYDEAGEDDKSSLVLTFSVDEPEGQWKNFASERDLGVGFAGEPTWAKLKATKLYSLDKDDEDCTVLKEFDISTALSQPRKNQKHAKGRYINERSSNDSVTTNLENKDESDLEEPLAKKQKTTSATASKTSGKAPARRAAGGKSVPRKATGGKTTREGVSNKTKAGRKK
Length1695
PositionKinase
OrganismCryptococcus depauperatus CBS 7841
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Cryptococcus.
Aromaticity0.07
Grand average of hydropathy-0.279
Instability index47.97
Isoelectric point6.19
Molecular weight190892.09
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10112
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     276.99|      84|     166|     212|     301|       1
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  212-  298 (124.96/97.33)	....................LADPI.PIDRAVWFIRviGANEIsVHRTRQS...TITSSVTAP.SPVAATPS...STTTVNAASPM..............pasSNEWYSQEFTNTLIQWLRIQLGQLAL
  299-  371 (42.15/21.44)	PPEgqntsasttsknlgsgiLQDEK.A..RAKWLIK..................................................wdystrllremhakdllSNRLFSGWLAEHLSQ...VNLAQLGF
  372-  464 (109.88/69.05)	LAQ............lvgeyLSDMIrHLDSARHCIR..AACEI.LTLLRESpvrDVLGKVEAMlSLYEANPDvllSPVTWKRYSPL.....................ISSIIRNTTSQWTNLQRRNEAL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|    1174.55|     392|     472|     756|    1202|       2
---------------------------------------------------------------------------
  756- 1202 (570.17/455.35)	ITQVFRQCHGYAT...IADFMIR..ALL....EAEDDDILDVVLDIIQRdadIWTSMDLWPRLGDKLLDRHHILESRGKehvrLMKLLRNLVQK.NRLMPDDqeeVNHLSLNIVRSPHSenlGLLSQDPLEILPQILLGGNKDIISTIAPalhrHYGFFHL..................WSSKWWTLIIDVIQKAESEQKLCLYRMISKHmIAVFQEyQESFDsivgsWLSSLASArLLDIfgKHTSKIMTqlllfLVSHRALSTTT.....IFDKmiyPIWKLTLMWAlPPRKR.......LSSEQIQSiVSTIDlVSqlLVLPPLESELPPTLLTEAIVIQASrqnifQDHHVKLLiqhMPVLVVFEQNQLLPEQTTTKIGEILNSLASSAEFKTAAFRHL.......SILKDAFLAREWSGPGMGQE.LEGRMVDvlklimsEKRTQSSPRTGIPSIDESG...RFSAWQWTRIVLEMRLEFKALAMRIADGQEV
 1229- 1671 (604.38/355.86)	LCEVFRGVDTTITheiVAAGMDRlsNLLgqaiGAETQQQLEAFIDSIHQ...ILRIVHCTSRESTQPITESSVLIARHK....LLDLLAVALQTiDRHMTTG...VDFLLPQGISPPQP...GHLLATVMTLLKFVLGTDTTDNGSLTAP....KPNFPHLavcflksivasetihdpdWIKEMCDMLAYIIDCTPFQSRLACQAILSNE.IALLNT.QSDFN.....FLPLLTSS.ILSI..TSIQRNMS.....LTTPDTIDDDThnpslLLDD...RRWELFEYMA.PPKRKigpqdlfLSSITLKD.HSSIP.IS..LFSPRLTRDAPPNVGTMDIYDEAG.....EDDKSSLV...LTFSVDEPEGQWKNFASERDLGVGFAGEPTWAKLKATKLYSLdkddedcTVLKEFDISTALSQPRKNQKhAKGRYIN.......ERSSNDSVTTNLENKDESDleePLAKKQKTTSATASKTSGKAPARRAAGGKSV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10112 with Med12 domain of Kingdom Fungi
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