<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10105

Description CMGC/CDK/CDK8 protein kinase
SequenceMSNNTLAVDPMVYYHAKRDRERRGVLKTYKILGFISSGTYGRVYKAVFLAPLTNTTASKSALPSAARAALSIPKDKILSPSLSEENPLLNPEMCMRPGDRPARKGDVFAIKKFKPDKEGDVLTYAGISQSGAREIMLNRELHHRNLVALREVILEDKSIYMVFEFAEHDFLQIIHHHSQTARTPIPPSTLRRLLHQLIMGVHYLHSNFVLHRDLKPANILVTNTGVVKIGDLGLARLWHKPLALQGLYGGDKVVVTIWYRAPELILGAKHYTAAVDMWAVGCIYAELLSLRPIFKGDEAKMDGKKQLPFQRDQMGKICEVLGPVKPEQWPDIVHLPEYRTYLSSGPYSNPNPLPTWYHTRSTSSEGYDLLSKMFEWDPARRVTARESLMHPWFQEEGGVSAKNVFEGSKITYPPRRVTHEDNGDAKMGSLPQSMAGARLPSSSNFRPASGSIQSSRKKAKI
Length461
PositionKinase
OrganismCryptococcus depauperatus CBS 7841
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Cryptococcus.
Aromaticity0.08
Grand average of hydropathy-0.366
Instability index45.60
Isoelectric point9.58
Molecular weight51806.14
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10105
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.83|      29|     195|      93|     126|       1
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   93-  126 (49.88/43.40)	MCMRP...GDRPARKGdvfaiKK...FKPDKEGDVLTYAG
  288-  322 (42.95/26.44)	LSLRPifkGDEAKMDG.....KKqlpFQRDQMGKICEVLG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10105 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ITYPPRRVTHEDNGDAKMGSLPQSMAGARLPSSSNFRPASGSIQSSRKKAKI
410
461










Molecular Recognition Features






MoRF SequenceStartStop




NANANA