<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10102

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTPDIFLGEPAKPTTSLAGTYLFSTPVNASVYIKRYRISLSHTVIKNGGHAAKIAADDRLEAFWKRLADKEGMTKEWMEDWVGVIVNGESGREIWCFSTSCSELQVQDGLEEIIPPLPPIVLQQCMACPVHASSTSCLSPDLGCVPTFIITGEPGKAWKLLKYALVEKIAWRHGFRILLAGPRFFPAINVSLCPFNHSALLLTVRNTPCSTSSSTHTLLPLLIPSYHLSTYSFTSQQSDQLTTSFDALLGHFWRKGKEEYIVQESLRGHDEGEWGIYWIHLFSAQEGVLVVWPKHLAIANSPPSSANTIPSANRFPSSSITELMGTAQSLFDFFTTYQPPSPPVADVEMLDADNIIDDKVGKDSDQVNVAVVADNVATESVLLPGLAKVVNGQSSPPEQPPSAQYEGSDIDDLFSDSSPTPQEMQKLSQQEDLSNAKSIFMPFANPVVETRDKRNIDDKNEGEVKDTLITEDDFAFFDSSRTDPEMGLSLQKTLKTDIDVMMSEKVEDVATIQENNTDDMNADSPSQDLGAAEIRDENVDAKGSIQIVEQSSMLRLVAEISKDPDDLAQSPSASLSLLEPQCKPNHRKHLPSLPSHPLIPINFSPLPLLPSVHFMHPYPYSPLSPIPTPSFSLIDRLRPKSIQPLNIDVWNFSDNSDESEMAYTEPPTPISELSERNSIDDKRDETESTISEEEEDLHWGGFKCIGAELLILNEEVEHLKVNWDSSWGTFPSSDSDKSKKDTQEDKCYKVTDWARLAQEVILNRSFRSALLVSETGCGHKFENEIAKILLDGGTRLNELAPDIMTKKFSQPLINTSTCFAHNIIRLSISSLPYWNELGLEPQGGQKDIKVMIVCEQEEDGKETLNAIKRSWKVNKMGNFEYAEPENEGVIVVFGPALLDTACKTPGPFITLANVFIGKLAQESGSAHNVVIYLLVRDFSDFLLPSLPSATTLIPLPLPTLSTSLDYEAIAFETYDRVLTPLHPIFTRGQAISISERDRWIPSPSWTLARREPAKPEFAMTYPIDDYDVLNRWRLFHLAYDFIEAKAIVWVGDGRGEAWEVCVLEGKDWQNIIRAIWKFGNETIRNWAGRFRLGVCKASLMEKGEFEAWQDLCKSQADPPTLVMSDSPLTKSCSMPIPQPVANIDPSILVDPNARLVNPSLTGHLTPLPYCLPVEILSSAEDNKETIYPQKSFFLTTLNRGQTCHLTTQYHILYHTLVAGKKDEDTVHEFGEEYYRLGCLVRERWGGEQWLDLIKWGKRALIT
Length1262
PositionKinase
OrganismCryptococcus depauperatus CBS 7841
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Cryptococcus.
Aromaticity0.08
Grand average of hydropathy-0.291
Instability index49.73
Isoelectric point4.86
Molecular weight140957.98
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10102
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     293.87|      76|     222|     383|     473|       1
---------------------------------------------------------------------------
  340-  358 ( 6.46/17.10)	P.SP.PVADVEMLDADNIIDD..........................................................
  397-  473 (127.17/66.84)	PEQP.PSAQYEGSDIDDLFSDS.SPTPQEMQKLSQQEDLSNAKSIFMPFANPVVETRDKRNIDDKNEgEVKDTLITEDD
  476-  521 (53.39/20.90)	..................FFDS.SRTDPEM.GLSLQKTLKTDIDVMMSEKVEDVATIQENNTDDMN.............
  622-  695 (106.85/50.73)	PLSPiPTPSF..SLIDRLRPKSiQPLNIDVWNFSDNSDESEMA..YTEPPTPISELSERNSIDDKRD.ETESTISEEEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     233.06|      50|     350|     560|     609|       2
---------------------------------------------------------------------------
  560-  609 (97.31/52.61)	ISKDPDDL..AQ.SP.....SAS...LSLLEPQ..........CKPNHRKHLPSLPS.HPLIPINFS.PLPLL
  916-  960 (55.76/26.81)	IGK....L..AQeSG.....SAHnvvIYLL.............VRDFSDFLLPSLPSaTTLIPL....PLPTL
  997- 1022 (29.49/10.50)	.....DRW..IP.SP.....SWT...LARREP...........AKPEFAMTYP....................
 1117- 1176 (50.50/23.54)	...DPPTLvmSD.SPltkscSMP...I....PQpvanidpsilVDPNARLVNPSLTG.H.LTPLPYClPVEIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.22|      17|     221|     834|     871|       3
---------------------------------------------------------------------------
  853-  871 (27.27/50.41)	VCEQEedGKETLNAIKRSW
 1060- 1076 (33.96/10.18)	VCVLE..GKDWQNIIRAIW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.42|      39|     188|      57|      95|       5
---------------------------------------------------------------------------
   57-   95 (72.11/36.94)	DDRLEAFWKRLAD....KEGM....TKEWMEDWVGVIVNGESGREIW
  246-  292 (61.31/30.49)	DALLGHFWRKGKEeyivQESLrghdEGEWGIYWIHLFSAQEGVLVVW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10102 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LAKVVNGQSSPPEQPPSAQYEGSDIDDLFSDSSPTPQEMQKLSQQEDLSNA
2) SDESEMAYTEPPTPISELSERNSIDDKRDETESTISE
3) SEKVEDVATIQENNTDDMNADSPSQDLGAAEIRD
386
656
503
436
692
536










Molecular Recognition Features






MoRF SequenceStartStop




NANANA