<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10100

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMASSHNPQLGSDPYFAYPTPAPEQVESELPPYFQDENVPLGLVLDRFAKKSNHDLRVLLGETLPRLPAKDRPKPIIEYAKTTRQALVKYLAVLRWKTSVDIPAHLTAAPPLTTSVGPTSFPTPHSNGDMELSPSYQGLNKPKSDEEKKSLQGKVTDAKRIAHFLEHQNQQHELAIEHAKHVVNVVEGLRERNPDILTALSLQTNGTYNRLPTSVVDPYLPKQPLTNSSILKVLRKLNQQIRYRLRCLDHVPSDLIIEGIKDGRVYVRGSHWRAELTVVGFGDASRWWLTGLAWGWKAKDRGIDDPGGMPGDSKQNRRFTGDELQGILDLVNAEVLVPRDVSLGEVDQNFQSDIEPSSKASVDAPLSRLYNIIEHLSLNYQLETLYSQAVDLSQGRWRGQLLPEIDRIAKTLRLRYWIQRRHGPDSSRRLHSQGQKPASAPLIFGGSLLISISESNTLKSPLEDLLNDISLCEAKSCERSLKLELAIKWIVEEGGAGGGMNAGDVMDNLQLQLNPESLTVEDLLSVATRTHAAHLTRAYTVPLYSSARLIVAAPPFFDSSTDSTERPLTFLIPLPSRQTQSRSNLGIGVSSFTGLLEIVDEGAGLDGARKDRARTSSNNVNDNKSSLSDEVWRLSVAAVMDNMETQLRQLGYHPTRHIPLRLKELVKANLHPLSTLFLALPASPYHYFVTQIQHPMGPAMGINFQIIKLVPSSSDSGIGTKWDIGDQTSVSLEKLRARRKIDAAETQITPPLYEVDNHDLKELCILSNALVAQNIVEQQLKDRSIPYTSVFPPPSGPASPKSNSPLAGMIPTLCVDVRDLLRSLGRKGAGAGEAAVDVAFPKVWLQIEGWWDGGFCEVSTIVVLRHQPHMSSADSVNPLVDGADTDGDEAHEARAEGIFFDPLSSIVRFKAKTINQCVPSFLEQWERLSKVIAVAGEVNRLNQKPVLADVKLLSFDLRKASLQYAPNHIASITYSPSNDSYQITFSISIPSSSPPNPPARSNPHTLLASLFSAKLNELTAQSSSAMRQKGEVGYQLCGLLQGTLPILSLSGDLRAQGASGWQLVVLDITRFQFVRDHKYRRYVLLVTLLPDLRHYLIQDGSLFEDFNGVDSYLGFLTPIPDSENLFFSALKTFPNSKTGAAEAPTLVSGLSDKGLYMESSSMVLDGGKAVMCGIAEFGLLMAKILSLIEGSF
Length1191
PositionTail
OrganismCryptococcus amylolentus CBS 6039
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Cryptococcus.
Aromaticity0.07
Grand average of hydropathy-0.248
Instability index44.67
Isoelectric point6.38
Molecular weight131199.74
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10100
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.70|      23|     190|     291|     315|       1
---------------------------------------------------------------------------
  291-  315 (41.67/31.47)	LAWGWKAKDRGIDdpGGM.PGDSKQN
  484-  507 (39.03/22.27)	LAIKWIVEEGGAG..GGMnAGDVMDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     137.31|      44|     441|     553|     596|       2
---------------------------------------------------------------------------
  553-  579 (36.49/17.21)	......................................PPFFDSSTDSTERPLTFLIPLPSRQTQ
  711-  774 (47.43/24.75)	SSSDSGIGtkwdIGDQTSVsLEklrarrkidaaetqitPPLYEVDNHDL.KELCILSNALVAQNI
  775-  810 (53.39/28.86)	VEQQLKDR....SIPYTSV.FP................PPSGPASPKS.NSPLAGMIP.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.78|      20|      20|     249|     268|       3
---------------------------------------------------------------------------
  249-  268 (35.35/25.89)	HVPSDLIIEGIKD.GRVYVRG
  270-  290 (35.43/25.96)	HWRAELTVVGFGDaSRWWLTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.65|      11|      18|     440|     453|       5
---------------------------------------------------------------------------
  440-  453 (14.48/16.27)	PLifgGSLL..ISISE
  460-  472 (16.16/ 7.35)	PL...EDLLndISLCE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.07|      13|      20|      38|      50|       6
---------------------------------------------------------------------------
   38-   50 (22.46/14.28)	VPLGLVLDRFAKK
   57-   69 (22.61/14.44)	VLLGETLPRLPAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.28|      16|      20|     975|     990|       8
---------------------------------------------------------------------------
  975-  990 (28.66/16.39)	PSNDSYQITFSISIPS
  996- 1011 (28.61/16.35)	PPARSNPHTLLASLFS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10100 with Med14 domain of Kingdom Fungi
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