<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10083

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRASSATFRVGFPSPSSPSVGYLKENDQPYISSDHFPQTPTSPPLMSVSAQSHATHFAPSQTSPRQATSQSADYSSLPSSDPMSSQVSQQPTLSSTTTSFPTPASSVSGHLVDADKSTGTGMQESGSTVMADANVAPTQTPPEHTQTDHDRNMGGADPGTGVRDSANMDAMEIDNNDNSGSSNNEGAASSENNDFSLDSLQREFTSAYHLCKSSHVVTGPDPSLDLVSLYGLGPIAKSVARMDPVTGEKINRLRKSYEGKLKGLGLAGRNKPVKNEAGMPGSLRHLTMWPEEEWQNQNVFGKQIKIADMDSALQQLQMKAMKLEPGTVPNNDYWEDVLGHEKPSKHVGAGDAGKKAAAPSGGVRAPSQSNGTPAPAELERSRPSRGHKRRYDDNSFVGYGEGYADDDDEGAFYSNSEGIGKKKRKKV
Length429
PositionHead
OrganismAspergillus cristatus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.835
Instability index50.16
Isoelectric point5.66
Molecular weight45752.53
Publications
PubMed=27267057

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP10083
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     103.83|      20|      21|      71|      90|       1
---------------------------------------------------------------------------
   29-   51 (22.73/ 7.93)	DQpyiSSDhFPQTPTSPPL.MS.VS
   52-   70 (24.31/ 8.99)	AQ...SHA.THFAPSQTS..PRQAT
   71-   90 (33.27/15.03)	SQ...SAD.YSSLPSSDPM.SSQVS
   91-  110 (23.52/ 8.46)	QQ....PT.LSSTTTSFPTpASSVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.22|      15|      15|     167|     181|       2
---------------------------------------------------------------------------
  167-  181 (27.56/17.26)	SANMDAMEIDNNDNS
  184-  198 (26.67/16.48)	SNNEGAASSENNDFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.32|      44|     228|     111|     163|       3
---------------------------------------------------------------------------
  111-  163 (64.68/50.90)	GHlVDADKSTGTGmqESGSTVMADAN..VAPTQT..PPEHTQTDHDRnmggadPGTG
  341-  388 (68.64/33.45)	GH.EKPSKHVGAG..DAGKKAAAPSGgvRAPSQSngTPAPAELERSR......PSRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.42|      11|      14|     394|     404|       4
---------------------------------------------------------------------------
  394-  404 (21.09/12.21)	DDNSFVGYGEG
  410-  420 (20.33/11.53)	DEGAFYSNSEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.89|      19|      24|     206|     224|       5
---------------------------------------------------------------------------
  206-  224 (36.04/22.74)	FTSAYHLCKSSHVVTGPDP
  228-  246 (32.86/20.14)	LVSLYGLGPIAKSVARMDP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10083 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PNNDYWEDVLGHEKPSKHVGAGDAGKKAAAPSGGVRAPSQSNGTPAPAELERSRPSRGHKRRYDDNSFVGYG
2) RASSATFRVGFPSPSSPSVGYLKENDQPYISSDHFPQTPTSPPLMSVSAQSHATHFAPSQTSPRQATSQSADYSSLPSSDPMSSQVSQQPTLSSTTTSFPTPASSVSGHLVDADKSTGTGMQESGSTVMADANVAPTQTPPEHTQTDHDRNMGGADPGTGVRDSANMDAMEIDNNDNSGSSNNEGAASSENNDFSLDS
331
4
402
201










Molecular Recognition Features






MoRF SequenceStartStop




1) KRRYDDNSFVGYGEGYADDDDEGAFYSNSEGIGKKKRKKV
2) PSVGYLKENDQPYISSDHF
3) SATFRVGFPS
390
20
7
429
38
16